Abciximab
Reopro (abciximab) is an antibody pharmaceutical. Abciximab was first approved as Reopro on 1994-12-22. It is used to treat unstable angina in the USA. The pharmaceutical is active against integrin beta-3. In addition, it is known to target integrin alpha-IIb.
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Target
Variants
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Trends
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2Y
5Y
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FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
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Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| cardiovascular diseases | D002318 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Abciximab
Tradename | Proper name | Company | Number | Date | Products |
|---|---|---|---|---|---|
| Reopro | abciximab | Johnson & Johnson | N-103575 DISCN | 1994-12-22 | 1 products |
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| unstable angina | EFO_1000985 | D000789 | I20.0 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| G9531 | Patient has documentation of ventricular shunt, brain tumor, multisystem trauma, or is currently taking an antiplatelet medication including: abciximab, anagrelide, cangrelor, cilostazol, clopidogrel, dipyridamole, eptifibatide, prasugrel, ticlopidine, ticagrelor, tirofiban, or vorapaxar |
| J0130 | Injection abciximab, 10 mg |
Clinical
Clinical Trials
66 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Renal artery obstruction | D012078 | EFO_1001150 | N28.0 | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Abciximab |
| INN | abciximab |
| Description | Abciximab (chimeric Fab) |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | >6V4P:C|Abciximab, heavy chain
EVQLQQSGTVLARPGASVKMSCEASGYTFTNYWMHWVKQRPGQGLEWIGAIYPGNSDTSYIQKFKGKAKLTAVTSTTSVY
MELSSLTNEDSAVYYCTLYDGYYVFAYWGQGTLVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWN
SGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH
>6V4P:D|Abciximab, light chain
EIVLTQSPVTLSVTPGDSVSLSCRASRDISNNLHWFQQTSHESPRLLIKYASQSMSGIPSRFSGSGSGTDFTLSINSVET
EDFGMYFCQQTNSWPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Identifiers
| PDB | 6V4P |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201584 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB00054 |
| UNII ID | X85G7936GV (ChemIDplus, GSRS) |
Target
Agency Approved
ITGB3
ITGB3
Organism
Homo sapiens
Gene name
ITGB3
Gene synonyms
GP3A
NCBI Gene ID
Protein name
integrin beta-3
Protein synonyms
antigen CD61, CD61, GPIIIa, integrin beta 3, integrin beta chain, beta 3, integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61), Platelet membrane glycoprotein IIIa
Uniprot ID
Mouse ortholog
Itgb3 (16416)
integrin beta-3 (Q3TZC6)
Alternate
ITGA2B
ITGA2B
Organism
Homo sapiens
Gene name
ITGA2B
Gene synonyms
GP2B, ITGAB
NCBI Gene ID
Protein name
integrin alpha-IIb
Protein synonyms
alphaIIb protein, CD41, GPalpha IIb, GPIIb, integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41), platelet fibrinogen receptor, alpha subunit, platelet glycoprotein IIb of IIb/IIIa complex, Platelet membrane glycoprotein IIb, platelet-specific antigen BAK, protein phosphatase 1, regulatory subunit 93
Uniprot ID
Mouse ortholog
Itga2b (16399)
integrin alpha-IIb (Q9Z2M0)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 5,269 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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3,185 adverse events reported
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