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Drug ReportsAbarelix
Abarelix
Plenaxis (abarelix) is a protein pharmaceutical. Abarelix was first approved as Plenaxis on 2003-11-25. The pharmaceutical is active against gonadotropin-releasing hormone receptor.
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Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Abarelix
Tradename
Company
Number
Date
Products
PLENAXISSpeciality European PharmaN-021320 DISCN2003-11-25
1 products
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
— L02: Endocrine therapy antineoplastic and immunomodulating agents
— L02B: Hormone antagonists and related agents
— L02BX: Other hormone antagonists and related agents in atc
— L02BX01: Abarelix
HCPCS
No data
Clinical
Clinical Trials
5 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Prostatic neoplasmsD011471—C611111—4
Indications Phases 3
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Indications Phases 2
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Indications Phases 1
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Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
EndometriosisD004715EFO_0001065N80————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameAbarelix
INNabarelix
Description
Abarelix is a polypeptide compound composed of ten natural and non-natural amino acid resiudes in a linear sequence. It has a role as a hormone antagonist and an antineoplastic agent.
Classification
Peptide
Drug classhormone-release inhibiting peptides
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N(C)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O
Identifiers
PDB—
CAS-ID183552-38-7
RxCUI—
ChEMBL IDCHEMBL1252
ChEBI ID337298
PubChem CID16131215
DrugBankDB00106
UNII IDW486SJ5824 (ChemIDplus, GSRS)
Target
Agency Approved
GNRHR
GNRHR
Organism
Homo sapiens
Gene name
GNRHR
Gene synonyms
GRHR
NCBI Gene ID
2798
Protein name
gonadotropin-releasing hormone receptor
Protein synonyms
gnRH receptor, gnRH-R, gonadotropin-releasing hormone (type 1) receptor 1, leutinizing hormone releasing horomone receptor, leutinizing-releasing hormone receptor, luliberin receptor, type I GnRH receptor
Uniprot ID
Q92644
Mouse ortholog
Gnrhr (14715)
gonadotropin-releasing hormone receptor (Q61611)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
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Additional graphs summarizing 373 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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76 adverse events reported
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