Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | 1 | 2 | — | — | — | 3 |
Left ventricular dysfunction | D018487 | — | — | — | 1 | — | — | — | 1 |
Ventricular dysfunction | D018754 | — | — | — | 1 | — | — | — | 1 |
Left ventricular function | D016277 | EFO_0004295 | — | — | 1 | — | — | — | 1 |
Atrial flutter | D001282 | EFO_0003911 | — | — | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Healthy volunteers/patients | — | — | — | 8 | — | — | — | — | 8 |
Drug common name | AZD1305 |
INN | — |
Description | AZD1305 is an experimental drug candidate that is under investigation for the management and reversal of cardiac arrhythmias, specifically atrial fibrillation and flutter. In vitro studies have shown that this combined-ion channel blocker inhibits rapidly the activating delayed-rectifier potassium current (IKr), L-type calcium current, and inward sodium current (INa).
|
Classification | Small molecule |
Drug class | — |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | CC(C)(C)OC(=O)NCCN1CC2CN(CCOc3ccc(C#N)cc3F)CC(C1)O2 |
PDB | — |
CAS-ID | 872045-91-5 |
RxCUI | — |
ChEMBL ID | CHEMBL3545169 |
ChEBI ID | — |
PubChem CID | 15605092 |
DrugBank | — |
UNII ID | — |