AVADOMIDE
Avadomide is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target protein cereblon.
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Commercial
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Clinical
Clinical Trials
15 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 8 | 2 | — | — | — | 8 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 5 | 1 | — | — | — | 5 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 5 | 1 | — | — | — | 5 |
| Follicular lymphoma | D008224 | — | C82 | 2 | 1 | — | — | — | 2 |
| Carcinoma | D002277 | — | C80.0 | 2 | 1 | — | — | — | 2 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 2 | 1 | — | — | — | 2 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 2 | 1 | — | — | — | 2 |
| Neoplasms | D009369 | — | C80 | 1 | 1 | — | — | — | 1 |
| Leukemia | D007938 | — | C95 | 1 | 1 | — | — | — | 1 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 1 | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| B-cell lymphoma | D016393 | — | — | 2 | — | — | — | — | 2 |
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
| Multiple myeloma | D009101 | — | C90.0 | 1 | — | — | — | — | 1 |
| Glioblastoma | D005909 | EFO_0000515 | — | 1 | — | — | — | — | 1 |
| Plasma cell neoplasms | D054219 | — | — | 1 | — | — | — | — | 1 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | AVADOMIDE |
| INN | avadomide |
| Description | Avadomide is an experimental cereblon E3 ligase modulator, or thalidomide analog studied to see if it is effective against cancer.
|
| Classification | Small molecule |
| Drug class | thalidomide derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1nc2cccc(N)c2c(=O)n1C1CCC(=O)NC1=O |
Identifiers
| PDB | — |
| CAS-ID | 1015474-32-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3989934 |
| ChEBI ID | — |
| PubChem CID | 24967599 |
| DrugBank | DB14857 |
| UNII ID | 28DZS29F59 (ChemIDplus, GSRS) |
Target
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Trends
PubMed Central
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Additional graphs summarizing 178 documents
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Safety
Black-box Warning
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Adverse Events
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64 adverse events reported
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