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Drug ReportsAVADOMIDE
AVADOMIDE
Avadomide is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target protein cereblon.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
No data
Clinical
Clinical Trials
15 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
MelanomaD008545———1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-hodgkin lymphomaD008228—C85.91————1
LymphomaD008223—C85.91————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameAVADOMIDE
INNavadomide
Description
Avadomide is an experimental cereblon E3 ligase modulator, or thalidomide analog studied to see if it is effective against cancer.
Classification
Small molecule
Drug classthalidomide derivatives
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
Cc1nc2cccc(N)c2c(=O)n1C1CCC(=O)NC1=O
Identifiers
PDB—
CAS-ID1015474-32-4
RxCUI—
ChEMBL IDCHEMBL3989934
ChEBI ID—
PubChem CID24967599
DrugBankDB14857
UNII ID28DZS29F59 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CRBN
CRBN
Organism
Homo sapiens
Gene name
CRBN
Gene synonyms
NCBI Gene ID
51185
Protein name
protein cereblon
Protein synonyms
protein x 0001
Uniprot ID
Q9UHW4
Mouse ortholog
Crbn (58799)
protein cereblon (Q8C7D2)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 185 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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64 adverse events reported
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