ATACIGUAT
Ataciguat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target guanylate cyclase soluble subunit beta-1.
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FDA approval date
EMA approval date
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Study first post date
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Commercial
No data
Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Aortic valve stenosis | D001024 | HP_0001650 | — | 1 | 1 | — | — | — | 2 |
| Pathologic constriction | D003251 | — | — | 1 | 1 | — | — | — | 2 |
| Peripheral arterial disease | D058729 | EFO_0004265 | — | — | 1 | — | — | — | 1 |
| Intermittent claudication | D007383 | EFO_0003876 | I73.9 | — | 1 | — | — | — | 1 |
| Peripheral vascular diseases | D016491 | EFO_0003875 | I73.9 | — | 1 | — | — | — | 1 |
| Pain | D010146 | EFO_0003843 | R52 | — | 1 | — | — | — | 1 |
| Neuralgia | D009437 | EFO_0009430 | — | — | 1 | — | — | — | 1 |
| Calcinosis | D002114 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ATACIGUAT |
| INN | ataciguat |
| Description | Ataciguat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target guanylate cyclase soluble subunit beta-1. |
| Classification | Small molecule |
| Drug class | guanaline cyclase activators |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(Nc1ccc(S(=O)(=O)N2CCOCC2)cc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc(Cl)s1 |
Identifiers
| PDB | — |
| CAS-ID | 254877-67-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2107729 |
| ChEBI ID | — |
| PubChem CID | 213037 |
| DrugBank | — |
| UNII ID | QP166M390Q (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
GUCY1B1
GUCY1B1
Organism
Homo sapiens
Gene name
GUCY1B1
Gene synonyms
GUC1B3, GUCSB3, GUCY1B3
NCBI Gene ID
Protein name
guanylate cyclase soluble subunit beta-1
Protein synonyms
GCS-beta-1, GCS-beta-3, guanylate cyclase 1, soluble, beta 3, Guanylate cyclase soluble subunit beta-3, Soluble guanylate cyclase small subunit
Uniprot ID
Mouse ortholog
Gucy1b1 (54195)
guanylate cyclase soluble subunit beta-1 (O54865)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 97 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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