APLINDORE
Aplindore is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Restless legs syndrome | D012148 | EFO_0004270 | G25.81 | — | 2 | — | — | — | 2 |
| Psychomotor agitation | D011595 | — | — | — | 2 | — | — | — | 2 |
| Syndrome | D013577 | — | — | — | 2 | — | — | — | 2 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 2 | — | — | — | 2 |
Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | APLINDORE |
| INN | aplindore |
| Description | Aplindore (DAB-452) is a drug which acts as a partial agonist selective for the dopamine receptor D2. It is being developed by the pharmaceutical company Neurogen as a treatment for Parkinson's disease and restless legs syndrome.
|
| Classification | Small molecule |
| Drug class | dopamine D2D3 receptor modulators |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C1Cc2c(ccc3c2O[C@@H](CNCc2ccccc2)CO3)N1 |
Identifiers
| PDB | — |
| CAS-ID | 189681-71-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2110659 |
| ChEBI ID | — |
| PubChem CID | 6440763 |
| DrugBank | DB06620 |
| UNII ID | Q5O76TA0ML (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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