APIMOSTINEL
Apimostinel is a protein pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
6 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Depression | D003863 | — | F33.9 | 2 | 2 | — | — | — | 4 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 2 | 2 | — | — | — | 4 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | 2 | 1 | — | — | — | 3 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | APIMOSTINEL |
| INN | apimostinel |
| Description | Apimostinel (GATE-202, formerly NRX-1074) is an investigational antidepressant, acting as a novel and selective modulator of the NMDA receptor. It is currently under development for the acute treatment of major depressive disorder (MDD) by Gate Neurosciences, and previously by Naurex and Allergan. As of February 2015, an intravenous formulation of apimostinel has completed a phase IIa clinical trial for MDD.
|
| Classification | Protein |
| Drug class | N-methyl-D-asparate (NMDA) receptor antagonist/agonists, glycine recognition site |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@@]1(Cc1ccccc1)C(=O)N[C@H](C(N)=O)[C@@H](C)O |
Identifiers
| PDB | — |
| CAS-ID | 1421866-48-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3989872 |
| ChEBI ID | — |
| PubChem CID | 71249967 |
| DrugBank | — |
| UNII ID | TTT1F11FZB (ChemIDplus, GSRS) |
Target
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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