APILIMOD
Apilimod is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target 1-phosphatidylinositol 3-phosphate 5-kinase.
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Events Timeline
5D
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3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
No data
Clinical
Clinical Trials
10 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Crohn disease | D003424 | EFO_0000384 | K50 | 1 | 4 | — | — | — | 4 |
| Covid-19 | D000086382 | — | U07.1 | — | 1 | — | — | — | 1 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | 1 | — | — | — | 1 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | — | 1 | — | — | — | 1 |
| Amyotrophic lateral sclerosis | D000690 | EFO_0000253 | G12.21 | — | 1 | — | — | — | 1 |
| Motor neuron disease | D016472 | EFO_0003782 | G12.2 | — | 1 | — | — | — | 1 |
| Sclerosis | D012598 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 1 | — | — | — | — | 1 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | — | — | — | — | 1 |
| Lymphoma | D008223 | — | C85.9 | 1 | — | — | — | — | 1 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 1 | — | — | — | — | 1 |
| Inflammation | D007249 | MP_0001845 | — | 1 | — | — | — | — | 1 |
| Immunologic deficiency syndromes | D007153 | — | D84.9 | 1 | — | — | — | — | 1 |
| Common variable immunodeficiency | D017074 | EFO_0000367 | D83 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dementia | D003704 | EFO_0003862 | F03 | — | — | — | — | 1 | 1 |
| Frontotemporal dementia | D057180 | — | G31.0 | — | — | — | — | 1 | 1 |
| Primary progressive aphasia | D018888 | EFO_0009053 | G31.01 | — | — | — | — | 1 | 1 |
| Pick disease of the brain | D020774 | EFO_0003096 | G31.01 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | APILIMOD |
| INN | apilimod |
| Description | Apilimod (STA-5326) is a drug that was initially identified as an inhibitor of production of the interleukins IL-12 and IL-23, and developed for the oral treatment of autoimmune conditions such as Crohn's disease and rheumatoid arthritis, though clinical trial results were disappointing and development for these applications was not continued.
|
| Classification | Small molecule |
| Drug class | immunomodulators |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1cccc(/C=N/Nc2cc(N3CCOCC3)nc(OCCc3ccccn3)n2)c1 |
Identifiers
| PDB | — |
| CAS-ID | 520-36-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297643 |
| ChEBI ID | — |
| PubChem CID | 10173277 |
| DrugBank | DB05611 |
| UNII ID | GFW2K84S4L (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
PIKFYVE
PIKFYVE
Organism
Homo sapiens
Gene name
PIKFYVE
Gene synonyms
KIAA0981, PIP5K3
NCBI Gene ID
Protein name
1-phosphatidylinositol 3-phosphate 5-kinase
Protein synonyms
epididymis luminal protein 37, FYVE finger-containing phosphoinositide kinase, Phosphatidylinositol 3-phosphate 5-kinase type III, phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III, phosphoinositide kinase, FYVE finger containing, PIKfyve, PIPkin-III, Serine-protein kinase PIKFYVE, Type III PIP kinase, zinc finger, FYVE domain containing 29
Uniprot ID
Mouse ortholog
Pikfyve (18711)
1-phosphatidylinositol 3-phosphate 5-kinase (Q9Z1T6)
Variants
No data
Financial
No data
Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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