Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Myeloid leukemia acute | D015470 | — | C92.0 | 8 | 8 | — | — | — | 14 |
B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 6 | 5 | — | — | — | 9 |
Monocytic leukemia acute | D007948 | — | — | 2 | 4 | — | — | — | 6 |
Myelomonocytic leukemia acute | D015479 | — | C92.5 | 2 | 4 | — | — | — | 6 |
Myeloid leukemia | D007951 | — | C92 | 2 | 4 | — | — | — | 6 |
Erythroblastic leukemia acute | D004915 | EFO_1001257 | C94.0 | 2 | 4 | — | — | — | 6 |
Megakaryoblastic leukemia acute | D007947 | — | C94.2 | 2 | 3 | — | — | — | 5 |
Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 5 | 1 | — | — | — | 5 |
Waldenstrom macroglobulinemia | D008258 | HP_0005508 | C88.0 | 4 | 2 | — | — | — | 4 |
Lymphoma | D008223 | — | C85.9 | 2 | 3 | — | — | — | 4 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Neoplasms | D009369 | — | C80 | 18 | — | — | — | — | 18 |
Anemia | D000740 | HP_0001903 | D64.9 | 2 | — | — | — | — | 2 |
Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 2 | — | — | — | — | 2 |
Leukemia | D007938 | — | C95 | 1 | — | — | — | — | 1 |
Thrombocytopenia | D013921 | HP_0001873 | D69.6 | 1 | — | — | — | — | 1 |
Male breast neoplasms | D018567 | — | — | 1 | — | — | — | — | 1 |
Hairy cell leukemia | D007943 | — | C91.4 | 1 | — | — | — | — | 1 |
Gastrointestinal stromal tumors | D046152 | EFO_0000505 | C49.A | 1 | — | — | — | — | 1 |
Non-small-cell lung carcinoma | D002289 | — | — | 1 | — | — | — | — | 1 |
Small cell carcinoma | D018288 | — | — | 1 | — | — | — | — | 1 |
Drug common name | ALVOCIDIB |
INN | alvocidib |
Description | Alvocidib is a synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation. It has a role as an antineoplastic agent, an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor, an antirheumatic drug and an apoptosis inducer. It is a dihydroxyflavone, a hydroxypiperidine, a member of monochlorobenzenes and a tertiary amino compound. It is a conjugate base of an alvocidib(1+). |
Classification | Small molecule |
Drug class | — |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | CN1CC[C@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@H](O)C1 |
PDB | — |
CAS-ID | 146426-40-6 |
RxCUI | — |
ChEMBL ID | CHEMBL428690 |
ChEBI ID | — |
PubChem CID | 5287969 |
DrugBank | DB03496 |
UNII ID | 45AD6X575G (ChemIDplus, GSRS) |