ALVOCIDIB
Alvocidib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against cyclin-dependent kinase 2 and cyclin-dependent kinase 4.
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Commercial
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Clinical
Clinical Trials
65 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 19 | 1 | — | — | 1 | 21 |
| Leukemia | D007938 | — | C95 | 11 | 10 | — | — | — | 18 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 8 | 8 | — | — | — | 14 |
| Myeloid leukemia | D007951 | — | C92 | 6 | 8 | — | — | — | 12 |
| Lymphoma | D008223 | — | C85.9 | 9 | 5 | — | — | — | 11 |
| Lymphoid leukemia | D007945 | — | C91 | 7 | 5 | — | — | — | 10 |
| Recurrence | D012008 | — | — | 7 | 4 | — | — | — | 9 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 6 | 5 | — | — | — | 9 |
| Mantle-cell lymphoma | D020522 | — | C83.1 | 4 | 4 | — | — | — | 6 |
| Monocytic leukemia acute | D007948 | — | — | 2 | 4 | — | — | — | 6 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anemia | D000740 | EFO_0004272 | D64.9 | 2 | — | — | — | — | 2 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 2 | — | — | — | — | 2 |
| Myeloid leukemia chronic-phase | D015466 | — | — | 2 | — | — | — | — | 2 |
| Blast crisis | D001752 | — | — | 2 | — | — | — | — | 2 |
| Thrombocytopenia | D013921 | HP_0001873 | D69.6 | 1 | — | — | — | — | 1 |
| Refractory anemia with excess of blasts | D000754 | — | D46.2 | 1 | — | — | — | — | 1 |
| Refractory anemia | D000753 | — | D46.4 | 1 | — | — | — | — | 1 |
| Hairy cell leukemia | D007943 | — | C91.4 | 1 | — | — | — | — | 1 |
| Gastrointestinal stromal tumors | D046152 | EFO_0000505 | C49.A | 1 | — | — | — | — | 1 |
| Hematologic neoplasms | D019337 | — | — | 1 | — | — | — | — | 1 |
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ALVOCIDIB |
| INN | alvocidib |
| Description | Alvocidib is a synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation. It has a role as an antineoplastic agent, an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor, an antirheumatic drug and an apoptosis inducer. It is a dihydroxyflavone, a hydroxypiperidine, a member of monochlorobenzenes and a tertiary amino compound. It is a conjugate base of an alvocidib(1+). |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN1CC[C@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@H](O)C1 |
Identifiers
| PDB | — |
| CAS-ID | 146426-40-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL428690 |
| ChEBI ID | — |
| PubChem CID | 5287969 |
| DrugBank | DB03496 |
| UNII ID | 45AD6X575G (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
CCNT1
CCNT1
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Safety
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72 adverse events reported
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