CEP-32496
Cep-32496 is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target RAF proto-oncogene serine/threonine-protein kinase and serine/threonine-protein kinase B-raf.
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Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
No data
Clinical
Clinical Trials
3 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 1 | — | — | — | — | 1 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | — | — | — | — | 1 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 1 | — | — | — | — | 1 |
| Ovarian epithelial carcinoma | D000077216 | — | — | 1 | — | — | — | — | 1 |
| Neoplasms | D009369 | — | C80 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | CEP-32496 |
| INN | agerafenib |
| Description | Cep-32496 is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target RAF proto-oncogene serine/threonine-protein kinase and serine/threonine-protein kinase B-raf. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(C(C)(C)C(F)(F)F)on4)c3)c2cc1OC |
Identifiers
| PDB | — |
| CAS-ID | 1188910-76-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2029988 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 78I4VEX88N (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
RAF1
RAF1
BRAF
BRAF
Organism
Homo sapiens
Gene name
RAF1
Gene synonyms
RAF
NCBI Gene ID
Protein name
RAF proto-oncogene serine/threonine-protein kinase
Protein synonyms
C-Raf proto-oncogene, serine/threonine kinase, cRaf, Oncogene RAF1, Proto-oncogene c-RAF, raf proto-oncogene serine/threonine protein kinase, Raf-1, v-raf-1 murine leukemia viral oncogene homolog 1, v-raf-1 murine leukemia viral oncogene-like protein 1
Uniprot ID
Mouse ortholog
Raf1 (110157)
RAF proto-oncogene serine/threonine-protein kinase (Q9QUU8)
Variants
No data
Financial
No data
Trends
No data
Safety
Black-box Warning
No Black-box warning
Adverse Events
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