ADAVOSERTIB
Adavosertib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against wee1-like protein kinase.
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Commercial
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Clinical
Clinical Trials
61 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 12 | 3 | — | — | — | 14 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 3 | 5 | — | — | — | 8 |
| Lung neoplasms | D008175 | — | C34.90 | 1 | 7 | — | — | — | 8 |
| Carcinoma | D002277 | — | C80.0 | 4 | 2 | — | — | — | 6 |
| Small cell lung carcinoma | D055752 | — | — | 1 | 4 | — | — | — | 5 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 2 | 4 | — | — | — | 4 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 3 | 1 | — | — | — | 4 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 2 | 2 | — | — | — | 4 |
| Squamous cell carcinoma | D002294 | — | — | 3 | 1 | — | — | — | 4 |
| Uterine cervical neoplasms | D002583 | — | — | 2 | 2 | — | — | — | 3 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glioblastoma | D005909 | EFO_0000515 | — | 3 | — | — | — | — | 3 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 1 | — | — | — | — | 1 |
| Blast crisis | D001752 | — | — | 1 | — | — | — | — | 1 |
| Second primary neoplasms | D016609 | — | — | 1 | — | — | — | — | 1 |
| Esophageal squamous cell carcinoma | D000077277 | — | — | 1 | — | — | — | — | 1 |
| Squamous cell neoplasms | D018307 | — | — | 1 | — | — | — | — | 1 |
| Vaginal neoplasms | D014625 | — | C52 | 1 | — | — | — | — | 1 |
| Laryngeal neoplasms | D007822 | EFO_0003817 | C32 | 1 | — | — | — | — | 1 |
| Gliosarcoma | D018316 | — | — | 1 | — | — | — | — | 1 |
| Astrocytoma | D001254 | EFO_0000271 | — | 1 | — | — | — | — | 1 |
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ADAVOSERTIB |
| INN | adavosertib |
| Description | 1-[6-(2-hydroxypropan-2-yl)-2-pyridinyl]-6-[4-(4-methyl-1-piperazinyl)anilino]-2-prop-2-enyl-3-pyrazolo[3,4-d]pyrimidinone is a member of piperazines. |
| Classification | Small molecule |
| Drug class | serine/threonine kinase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C=CCn1c(=O)c2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc2n1-c1cccc(C(C)(C)O)n1 |
Identifiers
| PDB | — |
| CAS-ID | 1075739-30-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1976040 |
| ChEBI ID | — |
| PubChem CID | 24856436 |
| DrugBank | DB11740 |
| UNII ID | K2T6HJX3I3 (ChemIDplus, GSRS) |
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Safety
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42 adverse events reported
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