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Talphera(TLPH)

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Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

Nafamostat mesylate

acute kidney injury

chronic hepatitis d

,

,

acute kidney injury

drug interactions

,

therapeutic equivalency

,

,

coagulation protein disorders

,

insulin resistance

,

hepatic insufficiency

,

,

,

pharmacological phenomena

,

pituitary acth hypersecretion

,

,

biological availability

,

b-cell chronic lymphocytic leukemia

,

pulmonary fibrosis

,

,

depressive disorder

,

,

ulcerative colitis

,

inflammatory bowel diseases

,

,

pulmonary arterial hypertension

,

metabolic syndrome

,

autonomic nervous system diseases

,

pure autonomic failure

,

shy-drager syndrome

,

orthostatic hypotension

,

multiple system atrophy

,

nervous system diseases

,

primary dysautonomias

,

postural orthostatic tachycardia syndrome

,

medical sociology

,

squamous cell carcinoma

,

,

,

alcoholic intoxication

,

drinking behavior

,

respiratory syncytial virus infections

,

systemic scleroderma

,

localized scleroderma

,

diffuse scleroderma

,

neuromyelitis optica

,

pancreatic ductal carcinoma

,

diffuse intrinsic pontine glioma

,

,

cushing syndrome

,

bcr-abl positive chronic myelogenous leukemia

,

hodgkin disease

,

,

,

,

immune system diseases

,

,

,

abdominal aortic aneurysm

,

aortic aneurysm

,

merkel cell carcinoma

,

,

breast milk expression

,

postpartum period

,

,

platelet function tests

,

breast neoplasms

,

,

nephrotic syndrome

,

,

non-alcoholic fatty liver disease

,

,

ovarian neoplasms

,

,

,

myeloproliferative disorders

,

liver neoplasms

,

myelodysplastic syndromes

,

myeloid leukemia acute

,

ovarian epithelial carcinoma

,

,

interstitial lung diseases

,

rectal neoplasms

,

polycythemia vera

,

,

,

stomach neoplasms

,

biliary tract neoplasms

,

renal cell carcinoma

,

,

squamous cell carcinoma of head and neck

,

,

,

,

,

,

post-traumatic stress disorders

,

traumatic stress disorders

,

,

multi-infarct dementia

,

endometrial neoplasms

,

uterine cervical neoplasms

,

vaginal neoplasms

,

congenital abnormalities

,

myeloid leukemia

,

psychotic affective disorders

,

,

amyotrophic lateral sclerosis

,

motor neuron disease

,

graft rejection

,

peripheral nervous system diseases

,

hereditary sensory and autonomic neuropathies

,

intestinal diseases

,

,

fontan procedure

,

,

,

sinus arrhythmia

,

essential thrombocythemia

,

primary myelofibrosis

,

,

,

pathologic processes

,

severe acute respiratory syndrome-related coronavirus

,

hepatorenal syndrome

,

duodenal neoplasms

,

gastrointestinal stromal tumors

,

cholangiocarcinoma

,

gallbladder neoplasms

,

ampulla of vater cancer

,

paradoxical embolism

,

myelomonocytic leukemia chronic

,

myelomonocytic leukemia juvenile

,

respiration disorders

,

blood coagulation

,

staphylococcus aureus

,

muscle spasticity

,

hereditary spastic paraplegia

,

,

heart transplantation

,

,

neuroendocrine tumors

,

endocrine gland neoplasms

,

systemic lupus erythematosus

,

reperfusion injury

,

,

cardiac catheterization

,

balloon angioplasty coronary

,

vascular graft occlusion

,

chronic hepatitis c

,

chronic hepatitis b

,

heart valve prosthesis implantation

,

,

neurofibromatosis 1

,

neurofibrosarcoma

,

neurofibromatoses

,

nerve sheath neoplasms

,

geographic atrophy

,

heart valve prosthesis

,

fallopian tube neoplasms

,

vulvar neoplasms

,

cocaine-related disorders

,

,

,

hepatic veno-occlusive disease

,

bronchiolitis obliterans

,

,

respiratory aspiration

,

,

community-acquired pneumonia

,

coronary restenosis

,

small cell lung carcinoma

,

,

,

protein-losing enteropathies

,

triple negative breast neoplasms

,

,

,

enteral nutrition

,

,

,

hereditary angioedemas

,

,

non-small-cell lung carcinoma

,

psychotic disorders

,

intracranial thrombosis

,

,

,

cerebral hemorrhage

,

,

severe acute respiratory syndrome

,

graft vs host disease

,

transient ischemic attack

,

pancreatic neoplasms

,

esophageal neoplasms

,

replacement arthroplasty hip

,

,

prostatic neoplasms

,

,

,

surgical blood loss

,

postoperative hemorrhage

,

transcatheter aortic valve replacement

,

neoplasm metastasis

,

alzheimer disease

,

,

acquired immunodeficiency syndrome

,

,

cerebrovascular disorders

,

postoperative complications

,

,

female genital neoplasms

,

sickle cell anemia

,

,

rheumatic heart disease

,

rheumatic diseases

,

secondary prevention

,

intracranial sinus thrombosis

,

,

netherton syndrome

,

membranous glomerulonephritis

,

peritoneal dialysis

,

subarachnoid hemorrhage

,

subdural hematoma

,

cerebral small vessel diseases

,

mesenteric ischemia

,

precursor cell lymphoblastic leukemia-lymphoma

,

lymphoid leukemia

,

may-thurner syndrome

,

viral pneumonia

,

,

,

,

invasive candidiasis

,

,

,

invasive pulmonary aspergillosis

,

,

,

chronic fatigue syndrome

,

disseminated intravascular coagulation

,

vitamin b 6 deficiency

,

,

traumatic intracranial hemorrhage

,

pathologic dilatation

,

non-hodgkin lymphoma

,

anterior wall myocardial infarction

,

behcet syndrome

,

blood transfusion

,

periodontal diseases

,

hypertensive intracranial hemorrhage

,

cerebral intraventricular hemorrhage

,

,

budd-chiari syndrome

,

splenic infarction

,

,

ventricular outflow obstruction

,

,

knee prosthesis

,

,

intracranial aneurysm

,

extracorporeal membrane oxygenation

,

endovascular procedures

,

,

hematologic diseases

,

,

prostheses and implants

,

collagen diseases

,

coronary circulation

,

hereditary nonpolyposis colorectal neoplasms

,

peutz-jeghers syndrome

,

nasopharyngeal carcinoma

,

,

,

arteriosclerosis

,

,

urologic neoplasms

,

urogenital neoplasms

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

,

,

,

atrial fibrillation

,

,

thromboembolism

,

venous thromboembolism

,

healthy volunteers/patients

,

venous thrombosis

,

,

,

hypercholesterolemia

,

,

coronary artery disease

,

,

,

pulmonary embolism

,

myocardial infarction

,

acute coronary syndrome

,

,

,

ischemic stroke

,

alpha 1-antitrypsin deficiency

,

myocardial ischemia

,

coronary disease

,

cardiovascular diseases

,

atherosclerosis

,

,

renal insufficiency

,

,

,

hyperlipidemias

,

st elevation myocardial infarction

,

hyperlipoproteinemia type ii

,

,

peripheral arterial disease

,

,

kidney diseases

,

diabetes mellitus

,

thrombocytopenia

,

,

blood coagulation disorders

,

hemostatic disorders

,

chronic kidney failure

,

cerebral infarction

,

,

,

pathologic constriction

,

acute kidney injury

,

,

respiratory distress syndrome

,

liver cirrhosis

,

acute lung injury

,

,

,

peripheral vascular diseases

,

type 1 diabetes mellitus

,

chronic renal insufficiency

,

wounds and injuries

,

percutaneous coronary intervention

,

coronavirus infections

,

,

newborn respiratory distress syndrome

,

aortic valve stenosis

,

pharmacokinetics

,

coronary artery bypass

,

type 2 diabetes mellitus

,

,

intracranial arteriosclerosis

,

hyperlipoproteinemias

,

cognitive dysfunction

,

inferior wall myocardial infarction

,

atherosclerotic plaque

,

,

,

antithrombin iii deficiency

,

multiple myeloma

,

drug-related side effects and adverse reactions

,

replacement arthroplasty knee

,

unstable angina

,

pulmonary emphysema

,

cardiac surgical procedures

,

chronic obstructive pulmonary disease

,

respiratory insufficiency

,

,

communicable diseases

,

,

,

,

plasma cell neoplasms

,

,

,

obstructive lung diseases

,

heart valve diseases

,

homozygous familial hypercholesterolemia

,

colorectal neoplasms

,

antiphospholipid syndrome

,

aortic valve disease

,

intracranial hemorrhages

,

upper extremity deep vein thrombosis

,

cystic fibrosis

,

mitral valve stenosis

,

,

angina pectoris

,

hematologic neoplasms

,

bariatric surgery

,

postphlebitic syndrome

,

postthrombotic syndrome

,

,

embolism and thrombosis

,

knee osteoarthritis

,

vascular diseases

,

cardiopulmonary bypass

,

non-st elevated myocardial infarction

,

,

portal hypertension

,

antibiotic prophylaxis

,

,

hepatocellular carcinoma

,

patent foramen ovale

,

,

chronic pancreatitis

,

carotid stenosis

,

critical illness

,

thrombophlebitis

,

systemic inflammatory response syndrome

,

coronary aneurysm

,

chronic limb-threatening ischemia

,

aortic valve insufficiency

,

kidney transplantation

,

retinal vein occlusion

,

spinal cord injuries

,

,

hip osteoarthritis

,

colonic neoplasms

,

congenital heart defects

,

parkinson disease

,

mitral valve insufficiency

,

,

,

lung transplantation

,

,

migraine disorders

,

intermittent claudication

,

,

respiratory tract diseases

,

staphylococcal infections

,

,

replacement arthroplasty

,

carotid artery diseases

,

,

liver transplantation

,

arterial occlusive diseases

,

vascular calcification

,

,

cognition disorders

,

,

,

mucocutaneous lymph node syndrome

,

end stage liver disease

,

takotsubo cardiomyopathy

,

,

,

medication adherence

,

short bowel syndrome

,

,

ankle fractures

,

right ventricular dysfunction

,

pulmonary infarction

,

ventricular dysfunction

,

pulmonary heart disease

,

ventricular tachycardia

,

ventricular premature complexes

,

brain infarction

,

femoral neck fractures

,

femur head necrosis

,

asymptomatic diseases

,

hyperlipoproteinemia type iii

,

tumor lysis syndrome

,

tourette syndrome

,

,

randomized controlled trials as topic

,

cardiomyopathies

,

intracranial embolism

,

ventricular remodeling

,

immunosuppression therapy

,

,

multiple organ failure

,

coronary stenosis

,

metabolic diseases

,

lipid metabolism disorders

,

,

invasive fungal infections

,

invasive hydatidiform mole

,

optical coherence tomography

,

catheter-related infections

,

,

aortic dissection

,

,

,

irritable bowel syndrome

,

,

disease progression

,

,

,

hypersensitivity

,

nutritional requirements

,

postoperative cognitive complications

,

abdominal obesity

,

systolic heart failure

,

,

oral surgical procedures

,

,

,

,

,

therapeutic chemoembolization

,

,

renin-angiotensin system

,

microcirculation

,

diabetic nephropathies

,

,

premature birth

,

genetic polymorphism

,

,

insulin secretion

,

familial combined hyperlipidemia

,

multiple sclerosis

,

relapsing-remitting multiple sclerosis

,

kidney neoplasms

,

acth-secreting pituitary adenoma

,

thrombotic stroke

,

idiopathic pulmonary fibrosis

,

atrial remodeling

,

,

,

alcohol drinking

,

tobacco smoking

,

hepatic encephalopathy

,

traumatic brain injuries

,

,

lupus nephritis

,

,

mental disorders

,

lipid metabolism

,

major depressive disorder

,

acute aortic syndrome

,

,

,

,

human influenza

,

,

,

,

haemophilus influenzae type b

,

renal replacement therapy

,

microvascular angina

,

chronic periodontitis

,

,

chronic disease

,

tardive dyskinesia

,

,

schizophrenia spectrum and other psychotic disorders

,

gastrointestinal diseases

,

,

chinese traditional medicine

,

left ventricular dysfunction

,

systolic murmurs

,

fetal growth retardation

,

,

respiratory tract infections

,

spinal diseases

,

,

,

,

,

cryptococcal meningitis

,

muscle hypotonia

,

subdural hematoma chronic

,

pharmacogenomic testing

,

,

femoral fractures

,

urinary bladder neoplasms

,

capillary fragility

,

positron-emission tomography

,

,

emergence delirium

,

aortic diseases

,

alcoholic fatty liver

,

,

alternative complement pathway

,

computed tomography angiography

,

,

sepsis-associated encephalopathy

,

hypoalbuminemia

,

respiratory insufficiency

,

pharmacokinetics

,

biological availability

,

femur head necrosis

,

,

,

,

liver cirrhosis

,

,

prenatal diagnosis

,

,

craniocerebral trauma

,

,

,

breakthrough pain

,

,

local anesthesia

,

,

stomach neoplasms

,

,

sickle cell anemia

,

esophageal neoplasms

,

,

shoulder injuries

,

supratentorial neoplasms

,

digestive system surgical procedures

,

inflammatory bowel diseases

,

pancreatic diseases

,

,

cerebral infarction

,

pelvic floor disorders

,

,

,

,

,

traumatic brain injuries

,

,

,

simian acquired immunodeficiency syndrome

,

atrial fibrillation

,

postoperative pain

,

,

,

,

,

,

,

,

emergence delirium

,

general anesthesia

,

,

anesthesia and analgesia

,

postoperative nausea and vomiting

,

epidural anesthesia

,

patient-controlled analgesia

,

,

,

cesarean section

,

intravenous anesthesia

,

spinal anesthesia

,

,

drug-related side effects and adverse reactions

,

cognitive dysfunction

,

postoperative period

,

wounds and injuries

,

,

,

,

,

healthy volunteers/patients

,

morphine dependence

,

,

epidural analgesia

,

replacement arthroplasty knee

,

breast neoplasms

,

neuromuscular blockade

,

cardiac surgical procedures

,

postoperative cognitive complications

,

,

thoracic surgical procedures

,

depressive disorder

,

,

pancreatic neoplasms

,

,

postoperative complications

,

intratracheal intubation

,

,

coronary artery disease

,

myocardial ischemia

,

,

liver neoplasms

,

psychomotor agitation

,

myocardial infarction

,

laparoscopic cholecystectomy

,

obstetric labor complications

,

,

prostatic neoplasms

,

,

video-assisted thoracic surgery

,

urologic surgical procedures

,

,

orthopedic procedures

,

,

coronary artery bypass

,

postpartum depression

,

,

hepatocellular carcinoma

,

pain management

,

colonic neoplasms

,

non-small-cell lung carcinoma

,

heart valve diseases

,

urinary bladder neoplasms

,

aortic valve stenosis

,

coronary disease

,

,

obstetric labor

,

,

sleep apnea syndromes

,

,

,

acute lung injury

,

critical illness

,

,

obstructive sleep apnea

,

opioid-related disorders

,

,

residual neoplasm

,

,

,

,

,

,

carcinoma in situ

,

ductal carcinoma

,

intraductal carcinoma noninfiltrating

,

conscious sedation

,

,

trigeminal neuralgia

,

endotracheal anesthesia

,

arteriovenous malformations

,

,

,

,

,

congenital abnormalities

,

,

tooth extraction

,

,

osteochondrodysplasias

,

driving under the influence

,

patient satisfaction

,

,

,

therapeutic chemoembolization

,

,

recovery of function

,

,

,

stress fractures

,

,

respiratory distress syndrome

,

newborn respiratory distress syndrome

,

motion sickness

,

,

,

,

,

free tissue flaps

,

,

,

gynecologic surgical procedures

,

nociceptive pain

,

colorectal neoplasms

,

aortic dissection

,

,

,

airway management

,

anesthesia recovery period

,

gastrointestinal endoscopy

,

obstetrical analgesia

,

,

acute kidney injury

,

hip osteoarthritis

,

intraoperative awareness

,

electroencephalography

,

,

balanced anesthesia

,

multiple pulmonary nodules

,

solitary pulmonary nodule

,

respiratory aspiration

,

operative surgical procedures

,

inhalation anesthesia

,

,

,

ovarian neoplasms

,

replacement arthroplasty hip

,

anxiety disorders

,

breech presentation

,

inguinal hernia

,

ambulatory surgical procedures

,

umbilical hernia

,

,

conduction anesthesia

,

,

femoral neck fractures

,

,

colonic diseases

,

obstetric delivery

,

,

muscle weakness

,

liver transplantation

,

,

enhanced recovery after surgery

,

pleural diseases

,

predictive value of tests

,

gastrointestinal microbiome

,

,

fertilization in vitro

,

,

,

congenital heart defects

,

,

,

,

,

,

female genital neoplasms

,

,

spondylolisthesis

,

pregnancy outcome

,

mental disorders

,

mobility limitation

,

,

,

,

cerebral hemorrhage

,

,

peritoneal dialysis

,

pathologic dilatation

,

unconsciousness

,

heart septal defects

,

ventricular heart septal defects

,

,

minimally invasive surgical procedures

,

cardiovascular diseases

,

,

acute cholecystitis

,

,

acalculous cholecystitis

,

neurologic manifestations

,

kidney transplantation

,

aortic aneurysm

,

cardiopulmonary bypass

,

,

,

,

neurophysiological monitoring

,

,

moyamoya disease

,

rapid sequence induction and intubation

,

ovarian epithelial carcinoma

,

visual evoked potentials

,

,

,

autistic disorder

,

autism spectrum disorder

,

thoracic diseases

,

bariatric surgery

,

parkinson disease

,

deep brain stimulation

,

,

,

biliary tract diseases

,

thoracic neoplasms

,

subdural hematoma

,

,

subdural hematoma chronic

,

robotic surgical procedures

,

artificial respiration

,

intraoperative complications

,

,

hypersensitivity

,

immediate hypersensitivity

,

drug hypersensitivity

,

ambulatory care

,

,

segmental mastectomy

,

sentinel lymph node biopsy

,

femoral fractures

,

ischemic stroke

,

,

pulmonary hypertension

,

,

abdominal neoplasms

,

autologous blood transfusion

,

,

,

,

,

circadian rhythm

,

,

,

acupuncture analgesia

,

female genital diseases

,

bioaccumulation

,

gastrointestinal diseases

,

digestive system diseases

,

pelvic exenteration

,

,

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