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SpringWorks Therapeutics
SpringWorks Therapeutics
(SWTX)
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Trade Name
Drug Name
Approved
Patent Expires
Indication
Ogsiveo
Nirogacestat
2023-11-27
2025-2043
Desmoid tumors
Clinical Trials
Therapeutic Areas:
All
Classification:
All
Approval:
All
Status:
All
Phases:
All
Drug Name
Phase 1
Phase 2
Phase 3
Phase 4
Indication
MIRDAMETINIB
lung neoplasms
,
neurofibrosarcoma
,
nerve sheath neoplasms
,
liver diseases
,
hepatic insufficiency
,
healthy volunteers/patients
,
neoplasms
,
neurofibromatosis 1
,
neurofibromatoses
,
neurofibroma
,
non-small-cell lung carcinoma
,
colorectal neoplasms
,
plexiform neurofibroma
,
breast neoplasms
,
glioma
,
melanoma
,
colonic neoplasms
,
triple negative breast neoplasms
,
adenocarcinoma
,
adenocarcinoma of lung
,
congenital abnormalities
,
hemangioma
,
vascular malformations
,
arteriovenous malformations
,
lymphangioma
,
lymphatic abnormalities
,
cystic lymphangioma
,
histiocytosis
,
langerhans-cell histiocytosis
,
juvenile xanthogranuloma
,
sinus histiocytosis
,
liposarcoma
,
myxoid liposarcoma
,
multiple myeloma
,
plasma cell neoplasms
,
autonomic nervous system diseases
,
histiocytic sarcoma
Nirogacestat
neoplasms
,
ovarian neoplasms
,
granulosa cell tumor
,
desmoid tumors
,
fibroma
,
aggression
Bevifimod
healthy volunteers/patients
,
hepatic insufficiency
,
esophageal neoplasms
,
hiv infections
,
small cell lung carcinoma
,
pancreatic ductal carcinoma
,
multiple myeloma
,
plasma cell neoplasms
,
bronchiolitis obliterans syndrome
,
congenital abnormalities
,
chromosome aberrations
,
brain stem neoplasms
,
chronic hepatitis c
,
chronic hepatitis
,
typhoid fever
,
infertility
,
medulloblastoma
,
rhabdoid tumor
,
ependymoma
,
choroid plexus neoplasms
,
primitive neuroectodermal tumors
,
ganglioglioma
,
pinealoma
,
neuroepithelial neoplasms
,
ganglioneuroblastoma
,
neuroectodermal tumors
,
phenylketonurias
,
precursor t-cell lymphoblastic leukemia-lymphoma
,
nasopharyngeal carcinoma
,
ureteral neoplasms
,
pelvic neoplasms
,
adenoid cystic carcinoma
,
metabolic syndrome
,
follicular lymphoma
,
adenocarcinoma
,
pancreatic neoplasms
,
prostatic neoplasms
,
kidney neoplasms
,
recurrence
,
syndrome
,
head and neck neoplasms
,
neurofibromatoses
,
neurofibroma
,
liver neoplasms
,
liver diseases
,
neurofibromatosis 1
,
meningioma
,
plexiform neurofibroma
,
endometrial neoplasms
,
systemic scleroderma
,
diffuse scleroderma
,
b-cell chronic lymphocytic leukemia
,
neuroendocrine carcinoma
,
central nervous system neoplasms
,
ovarian neoplasms
,
t-cell lymphoma
,
mantle-cell lymphoma
,
urinary bladder neoplasms
,
squamous cell carcinoma
,
uterine cervical neoplasms
,
myelodysplastic syndromes
,
non-hodgkin lymphoma
,
nervous system neoplasms
,
hypereosinophilic syndrome
,
systemic mastocytosis
,
mastocytosis
,
uveal neoplasms
,
uveal melanoma
,
squamous cell carcinoma of head and neck
,
transitional cell carcinoma
,
castration-resistant prostatic neoplasms
,
primary myelofibrosis
,
metaplasia
,
graft vs host disease
,
adenocarcinoma of lung
,
diffuse intrinsic pontine glioma
,
disease progression
,
oligodendroglioma
,
neurofibromatosis 2
,
acoustic neuroma
,
neurilemmoma
,
hodgkin disease
,
islet cell carcinoma
,
hematologic diseases
,
myeloid leukemia accelerated phase
,
preleukemia
,
mast-cell leukemia
,
aggression
,
germ cell and embryonal neoplasms
,
tuberculosis
,
anaplastic thyroid carcinoma
,
t-cell lymphoma peripheral
,
waldenstrom macroglobulinemia
,
malignant mesothelioma
,
mesothelioma
,
gliosarcoma
,
cholangiocarcinoma
,
chronic disease
,
large-cell lymphoma anaplastic
,
plasma cell granuloma
,
diarrhea
,
skin neoplasms
,
neuroma
,
postmenopause
,
gouty arthritis
,
endocrine gland neoplasms
,
virus diseases
,
urogenital neoplasms
,
male genital diseases
,
prostatic diseases
,
abdominal neoplasms
,
male genital neoplasms
,
genital diseases
,
sjogren's syndrome
,
retinitis pigmentosa
,
retinitis
,
synovitis
,
giant cell tumors
,
pigmented villonodular synovitis
,
giant cell tumor of tendon sheath
,
choroidal neovascularization
,
pathologic neovascularization
,
hemangioblastoma
,
von hippel-lindau disease
,
inflammatory breast neoplasms
,
invasive hydatidiform mole
,
multidrug-resistant tuberculosis
,
local neoplasm recurrence
,
t-cell lymphoma cutaneous
,
peutz-jeghers syndrome
,
acute coronary syndrome
,
st elevation myocardial infarction
,
type 1 diabetes mellitus
,
hypoglycemia
,
intestinal neoplasms
,
testicular neoplasms
,
osteosarcoma
,
brain stem infarctions
,
epilepsy
,
sturge-weber syndrome
,
klippel-trenaunay-weber syndrome
,
neurofibrosarcoma
,
nerve sheath neoplasms
,
carcinoma in situ
,
breast diseases
,
multiple hamartoma syndrome
,
hamartoma
,
urologic neoplasms
,
fallopian tube neoplasms
,
t-cell leukemia
,
localized scleroderma
,
myelomonocytic leukemia chronic
,
myelomonocytic leukemia acute
,
myelomonocytic leukemia juvenile
,
ameloblastoma
,
adamantinoma
,
ovarian epithelial carcinoma
,
sickle cell anemia
,
streptococcus agalactiae
,
clear cell adenocarcinoma
,
adenomyoepithelioma
,
colorectal neoplasms
,
myeloid leukemia acute
,
lymphoma
,
glioblastoma
,
neoplasm metastasis
,
glioma
,
chronic urticaria
,
urticaria
,
brain neoplasms
,
hepatocellular carcinoma
,
astrocytoma
,
large b-cell lymphoma diffuse
,
thyroid neoplasms
,
thyroid diseases
,
sarcoma
,
b-cell lymphoma
,
blast crisis
,
hematologic neoplasms
,
triple negative breast neoplasms
,
hypertension
,
colonic neoplasms
,
arthritis
,
stomach neoplasms
,
carcinoid tumor
,
pulmonary arterial hypertension
,
familial primary pulmonary hypertension
,
fibrosis
,
gastrointestinal neoplasms
,
rectal neoplasms
,
meningitis
,
meningococcal meningitis
,
meningococcal infections
,
neuroblastoma
,
rheumatoid arthritis
,
multiple sclerosis
,
relapsing-remitting multiple sclerosis
,
organ transplantation
,
graft rejection
,
digestive system neoplasms
,
cutaneous malignant melanoma
,
stomatitis
,
lymphangioleiomyomatosis
,
lupus nephritis
,
nephritis
,
hypersensitivity
,
peanut hypersensitivity
,
chronic inducible urticaria
,
hidradenitis suppurativa
,
hidradenitis
,
interstitial lung diseases
,
seizures
,
lung transplantation
,
malignant carcinoid syndrome
,
serotonin syndrome
,
food hypersensitivity
,
psoriatic arthritis
,
psoriasis
,
muscular atrophy
,
spinal muscular atrophy
,
atrophy
,
mucositis
,
lung diseases
,
idiopathic pulmonary fibrosis
,
pulmonary fibrosis
,
covid-19
,
infectious skin diseases
,
bacterial skin diseases
,
skin diseases
,
myasthenia gravis
,
muscle weakness
,
neoplasms by histologic type
,
neoplasms by site
,
leukemia
,
myeloid leukemia
,
neoplasms
,
bcr-abl positive chronic myelogenous leukemia
,
breast neoplasms
,
carcinoma
,
lung neoplasms
,
non-small-cell lung carcinoma
,
renal cell carcinoma
,
melanoma
,
kidney transplantation
,
philadelphia chromosome
,
lymphoid leukemia
,
neuroendocrine tumors
,
gastrointestinal stromal tumors
,
precursor cell lymphoblastic leukemia-lymphoma
,
sclerosis
,
myeloid leukemia chronic-phase
,
liver transplantation
,
renal insufficiency
,
tuberous sclerosis
,
chronic kidney failure
,
heart transplantation
,
kidney diseases
,
islet cell adenoma
,
infections
,
angiomyolipoma
,
macular degeneration
,
hepatitis c
,
hepatitis
,
hepatitis a
,
autosomal dominant polycystic kidney
,
communicable diseases
,
polycystic kidney diseases
,
arthrogryposis
,
diabetes mellitus
,
tick-borne encephalitis
,
encephalitis
,
immunosuppression therapy
,
cytomegalovirus infections
,
rare diseases
,
large cell carcinoma
,
vascular diseases
,
macular edema
,
edema
,
vision disorders
,
low vision
,
type 2 diabetes mellitus
,
cross-sectional studies
,
viremia
,
polyomavirus infections
,
cryopyrin-associated periodic syndromes
,
polycythemia vera
,
polycythemia
,
heart failure
,
systolic heart failure
,
myocardial infarction
,
inflammation
,
infarction
,
inferior wall myocardial infarction
LIFIRAFENIB
neoplasms
Nepidermin
glioblastoma
,
glioma
,
hypertension
,
pulmonary hypertension
,
pulmonary arterial hypertension
,
heart failure
,
pulmonary edema
,
squamous cell carcinoma
,
squamous cell neoplasms
,
prostatic neoplasms
,
breast neoplasms
,
hiv infections
,
infections
,
ovarian neoplasms
,
acquired immunodeficiency syndrome
,
communicable diseases
,
melanoma
,
neoplasms
,
anemia
,
premature obstetric labor
,
nasal polyps
,
polyps
,
rhinosinusitis
,
recurrence
,
ovarian epithelial carcinoma
,
overactive urinary bladder
,
non-small-cell lung carcinoma
,
chronic renal insufficiency
,
kidney diseases
,
thrombocytopenic purpura idiopathic
,
thrombocytopenic purpura
,
purpura
,
vomiting
,
nausea
,
head and neck neoplasms
,
renal cell carcinoma
,
lung neoplasms
,
urinary tract infections
,
non-hodgkin lymphoma
,
lymphoma
,
fallopian tube neoplasms
,
peritoneal neoplasms
,
endometrial neoplasms
,
erectile dysfunction
,
gonorrhea
,
stroke
,
muscle spasticity
,
urinary incontinence
,
enuresis
,
osteoporosis
,
postmenopausal osteoporosis
,
stomach neoplasms
,
gastrointestinal neoplasms
,
digestive system neoplasms
,
acute coronary syndrome
,
syndrome
,
parkinson disease
,
human influenza
,
sarcoma
,
carcinoma
,
brain neoplasms
,
neoplasm metastasis
,
small cell lung carcinoma
,
thrombosis
,
venous thrombosis
,
thrombophlebitis
,
herpes simplex
,
postoperative nausea and vomiting
,
post-traumatic stress disorders
,
traumatic stress disorders
,
whooping cough
,
tetanus
,
diphtheria
,
triple negative breast neoplasms
,
mucinous adenocarcinoma
,
ductal carcinoma breast
,
inflammatory breast neoplasms
,
immunologic deficiency syndromes
,
uterine cervical neoplasms
,
atherosclerosis
,
onychomycosis
,
covid-19
,
b-cell lymphoma
,
systemic lupus erythematosus
,
coronary disease
,
coronary artery disease
,
myocardial ischemia
,
heart diseases
,
exanthema
Endocrine
healthy volunteers/patients
,
brain neoplasms
,
non-small-cell lung carcinoma
,
lung neoplasms
,
thyroid neoplasms
,
papillary thyroid cancer
,
thyroid diseases
,
melanoma
,
sarcoma
,
fibrosarcoma
,
myofibromatosis
,
colonic neoplasms
,
neuroendocrine carcinoma
,
obesity
,
type 2 diabetes mellitus
,
diabetes mellitus
,
male breast neoplasms
,
breast neoplasms
,
neoplasm metastasis
,
neoplasms
,
triple negative breast neoplasms
,
growth disorders
,
dwarfism
Pd0332991
neoplasms
,
non-hodgkin lymphoma
,
multiple myeloma
,
non-small-cell lung carcinoma
,
lung neoplasms
,
adenocarcinoma
,
squamous cell carcinoma
,
squamous cell neoplasms
,
carcinoma
,
serous cystadenocarcinoma
,
female genital neoplasms
,
breast neoplasms
,
triple negative breast neoplasms
,
male breast neoplasms
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