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Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

insulin resistance

,

autoimmune diseases of the nervous system

,

,

nervous system malformations

,

kidney diseases

,

,

,

chronic hepatitis d

,

,

herpesviridae infections

,

,

patient acceptance of health care

,

multiple sclerosis

,

,

relapsing-remitting multiple sclerosis

,

,

drug-related side effects and adverse reactions

,

leukoencephalopathies

,

progressive multifocal leukoencephalopathy

,

hepatitis b virus

,

,

,

,

treatment adherence and compliance

,

,

hepatocellular carcinoma

,

liver neoplasms

,

,

,

,

,

,

chronic hepatitis b

,

acquired immunodeficiency syndrome

,

,

chronic hepatitis

,

,

communicable diseases

,

immunologic deficiency syndromes

,

,

,

medication adherence

,

,

substance-related disorders

,

,

patient compliance

,

healthy volunteers/patients

,

,

chronic renal insufficiency

,

renal insufficiency

,

,

persistent infection

,

cognitive dysfunction

,

chronic hepatitis c

,

,

metabolic diseases

,

,

,

kidney transplantation

,

non-hodgkin lymphoma

,

burkitt lymphoma

,

,

,

neurocognitive disorders

,

sleep wake disorders

,

,

,

anxiety disorders

,

opioid-related disorders

,

metabolic bone diseases

,

,

morphine dependence

,

hiv seronegativity

,

,

,

,

recreational drug use

,

hiv seropositivity

,

,

liver cirrhosis

,

,

biliary liver cirrhosis

,

,

,

cardiovascular diseases

,

retinal diseases

,

metabolic syndrome

,

drug interactions

Sodium chloride

healthy volunteers/patients

,

atherosclerosis

,

,

,

chronic hepatitis b

,

communicable diseases

,

,

,

herpesviridae infections

,

,

,

idiopathic pulmonary fibrosis

,

pulmonary fibrosis

,

,

subarachnoid hemorrhage

,

malignant mesothelioma

,

,

non-hodgkin lymphoma

,

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

colorectal neoplasms

,

uterine cervical neoplasms

,

,

thrombocytopenic purpura idiopathic

,

thrombocytopenic purpura

,

,

,

transitional cell carcinoma

,

multiple sclerosis

,

,

rheumatoid arthritis

,

,

relapsing-remitting multiple sclerosis

,

,

chronic progressive multiple sclerosis

,

ulcerative colitis

,

,

,

,

pleural empyema

,

,

graft rejection

,

giant cell arteritis

,

polymyalgia rheumatica

,

kidney transplantation

,

,

drug-related side effects and adverse reactions

,

renal insufficiency

,

,

,

,

,

,

,

cardiovascular diseases

,

health risk behaviors

,

vascular stiffness

hepatic insufficiency

,

renal insufficiency

,

castration-resistant prostatic neoplasms

,

,

,

,

,

unknown primary neoplasms

,

immunomodulation

,

gram-positive bacterial infections

,

t-cell lymphoma peripheral

,

,

merkel cell carcinoma

,

mycosis fungoides

,

clear cell sarcoma

,

myelodysplastic syndromes

,

,

,

pulmonary sarcoidosis

,

lyme neuroborreliosis

,

hypertriglyceridemia

,

,

granuloma annulare

,

mycobacterium avium complex

,

thoracic neoplasms

,

pelvic neoplasms

,

,

,

brain neoplasms

,

stomach neoplasms

,

,

triple negative breast neoplasms

,

multiple myeloma

,

head and neck neoplasms

,

urinary bladder neoplasms

,

ovarian neoplasms

,

thyroid neoplasms

,

plasma cell neoplasms

,

,

small cell lung carcinoma

,

ovarian epithelial carcinoma

,

esophageal neoplasms

,

borrelia infections

,

endometrial neoplasms

,

thyroid diseases

,

keratoconjunctivitis sicca

,

dry eye syndromes

,

uveal neoplasms

,

respiratory syncytial viruses

,

,

,

transitional cell carcinoma

,

kidney diseases

,

small cell carcinoma

,

adenocarcinoma of lung

,

large-cell lymphoma anaplastic

,

,

,

pheochromocytoma

,

,

healthcare-associated pneumonia

,

systemic lupus erythematosus

,

alopecia areata

,

,

,

fallopian tube neoplasms

,

peritoneal neoplasms

,

oligodendroglioma

,

,

hemangioblastoma

,

urogenital neoplasms

,

,

central nervous system neoplasms

,

nervous system neoplasms

,

,

neurofibromatosis 1

,

neurofibromatoses

,

,

germ cell and embryonal neoplasms

,

carcinoid tumor

,

urethral neoplasms

,

ureteral neoplasms

,

alveolar soft part sarcoma

,

,

polycystic kidney diseases

,

autosomal dominant polycystic kidney

,

,

cholangiocarcinoma

,

gene rearrangement

,

lobular carcinoma

,

plasma cell leukemia

,

medulloblastoma

,

,

rhabdomyosarcoma

,

diffuse intrinsic pontine glioma

,

intraductal carcinoma noninfiltrating

,

b-cell lymphoma

,

cutaneous lupus erythematosus

,

keratoconjunctivitis

,

,

respiratory tract infections

,

,

,

,

hidradenitis suppurativa

,

,

meningococcal infections

,

neoadjuvant therapy

,

diabetes mellitus

,

type 1 diabetes mellitus

,

,

multidrug-resistant tuberculosis

,

von hippel-lindau disease

,

,

,

neurodermatitis

,

,

urologic neoplasms

,

urologic diseases

,

neoplasms by site

,

glandular and epithelial neoplasms

,

,

,

benign fibrous histiocytoma

,

,

malignant fibrous histiocytoma

,

myeloid leukemia accelerated phase

,

,

malignant mesothelioma

,

,

urinary bladder diseases

,

adrenal cortex neoplasms

,

adrenocortical carcinoma

,

second primary neoplasms

,

pulmonary tuberculosis

,

hematologic neoplasms

,

amyotrophic lateral sclerosis

,

motor neuron disease

,

mouth neoplasms

,

,

penile neoplasms

,

plexiform neurofibroma

,

,

testicular neoplasms

,

solitary fibrous tumors

,

,

hemangiopericytoma

,

male urogenital diseases

,

urogenital diseases

,

,

adenoid cystic carcinoma

,

,

hemangiosarcoma

,

systemic scleroderma

,

diffuse scleroderma

,

,

,

post-acute covid-19 syndrome

,

,

colorectal neoplasms

,

atopic dermatitis

,

,

,

,

,

kidney neoplasms

,

prostatic neoplasms

,

squamous cell carcinoma

,

hepatocellular carcinoma

,

liver neoplasms

,

pancreatic neoplasms

,

neoplasm metastasis

,

,

psoriatic arthritis

,

squamous cell neoplasms

,

squamous cell carcinoma of head and neck

,

,

male breast neoplasms

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

lymphoid leukemia

,

myeloid leukemia chronic-phase

,

juvenile arthritis

,

,

,

bacterial pneumonia

,

,

mycobacterium avium-intracellulare infection

,

immune system diseases

,

inborn genetic diseases

,

genetic skin diseases

,

eczematous skin diseases

,

hypersensitivity

,

immediate hypersensitivity

,

islet cell carcinoma

,

ankylosing spondylitis

,

bacterial infections

,

pancreatic ductal carcinoma

,

,

,

febrile neutropenia

,

,

mycobacterium infections

,

adenosquamous carcinoma

,

large cell carcinoma

,

nervous system diseases

,

optic nerve diseases

,

disease progression

,

cardiovascular diseases

,

immunologic deficiency syndromes

,

breast neoplasms

,

healthy volunteers/patients

,

,

renal cell carcinoma

,

non-small-cell lung carcinoma

,

,

,

rheumatoid arthritis

,

,

,

,

,

acquired immunodeficiency syndrome

,

communicable diseases

,

bcr-abl positive chronic myelogenous leukemia

,

,

myeloid leukemia

,

neuroendocrine tumors

,

gastrointestinal stromal tumors

,

ulcerative colitis

,

,

,

non-hodgkin lymphoma

,

kidney transplantation

,

philadelphia chromosome

,

islet cell adenoma

,

intraabdominal infections

,

mantle-cell lymphoma

,

,

spondylarthritis

,

,

gastrointestinal neoplasms

,

digestive system neoplasms

,

,

,

,

,

,

ventilator-associated pneumonia

,

chronic hepatitis c

,

,

axial spondyloarthritis

,

,

premature birth

,

bacterial vaginosis

,

vaginal diseases

,

,

infectious skin diseases

,

soft tissue infections

,

,

,

community-acquired infections

,

staphylococcal infections

,

,

hypercholesterolemia

,

coronary disease

,

coronary artery disease

,

myocardial ischemia

,

,

bacterial skin diseases

,

,

asymptomatic infections

,

,

,

respiratory tract diseases

TENOFOVIR EXALIDEX

healthy volunteers/patients

Mucopolysaccharide

mucopolysaccharidoses

,

mucopolysaccharidosis i

,

tooth extraction

,

,

,

,

,

bone transplantation

,

,

neurogenic urinary bladder

,

,

,

,

duchenne muscular dystrophy

,

muscular dystrophies

,

merkel cell carcinoma

,

squamous cell neoplasms

,

basal cell neoplasms

,

cutaneous malignant melanoma

,

immune system diseases

,

hypoparathyroidism

,

,

systemic scleroderma

,

systemic lupus erythematosus

,

diffuse scleroderma

,

,

cytomegalovirus

,

,

graft pancreatitis

,

osteochondrodysplasias

,

urinary bladder neck obstruction

,

bladder exstrophy

,

,

adenoviridae infections

,

,

hodgkin disease

,

b-cell chronic lymphocytic leukemia

,

hematologic diseases

,

t-cell lymphoma

,

,

mantle-cell lymphoma

,

,

b-cell lymphoma

,

congenital abnormalities

,

large b-cell lymphoma diffuse

,

myelomonocytic leukemia juvenile

,

,

myelomonocytic leukemia chronic

,

aplastic anemia

,

t-cell lymphoma peripheral

,

tissue preservation

,

digeorge syndrome

,

waldenstrom macroglobulinemia

,

burkitt lymphoma

,

bone marrow transplantation

,

,

homologous transplantation

,

prolymphocytic leukemia

,

,

severe combined immunodeficiency

,

refractory anemia with excess of blasts

,

paroxysmal hemoglobinuria

,

,

renal cell carcinoma

,

,

,

,

b-cell lymphoma marginal zone

,

t-cell lymphoma cutaneous

,

plasmablastic lymphoma

,

large-cell lymphoma immunoblastic

,

myeloid leukemia accelerated phase

,

refractory anemia

,

,

sickle cell anemia

,

,

metabolic diseases

,

sinus floor augmentation

,

edentulous mouth

,

plasma cell leukemia

,

sezary syndrome

,

large-cell lymphoma anaplastic

,

lymphomatoid granulomatosis

,

leukemia myeloid chronic atypical bcr-abl negative

,

polycythemia vera

,

,

kidney neoplasms

,

precancerous conditions

,

spinal dysraphism

,

chronic disease

,

,

cartilage fractures

,

maxillary sinusitis

,

myelomonocytic leukemia acute

,

erythroblastic leukemia acute

,

prolymphocytic leukemia t-cell

,

,

islets of langerhans transplantation

,

basal cell carcinoma

,

extranodal nk-t-cell lymphoma

,

immunoblastic lymphadenopathy

,

mycosis fungoides

,

adult t-cell leukemia-lymphoma

,

hairy cell leukemia

,

intraocular lymphoma

,

large granular lymphocytic leukemia

,

t-cell leukemia

,

,

,

essential thrombocythemia

,

,

thrombocytopenia

,

,

,

,

glomerulonephritis

,

inborn genetic diseases

,

primary immunodeficiency diseases

,

metabolic syndrome

,

wiskott-aldrich syndrome

,

chronic granulomatous disease

,

,

hemoglobinopathies

,

,

philadelphia chromosome

,

mucopolysaccharidosis i

,

wound infection

,

end stage liver disease

,

tracheal stenosis

,

peripheral nerve injuries

,

limbal stem cell deficiency

,

,

human influenza

,

respiratory aspiration

,

myocardial infarction

,

,

induction chemotherapy

,

megakaryoblastic leukemia acute

,

monocytic leukemia acute

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

autologous transplantation

,

myeloid sarcoma

,

,

neural tube defects

,

pathologic complete response

,

phenylketonurias

,

,

fanconi syndrome

,

diabetic nephropathies

,

iga glomerulonephritis

,

renal hypertension

,

acquired immunodeficiency syndrome

,

prolymphocytic leukemia b-cell

,

brain stem neoplasms

,

medullary carcinoma

,

castleman disease

,

peripheral blood stem cell transplantation

,

diamond-blackfan anemia

,

respiratory signs and symptoms

,

complement activation

,

experimental diabetes mellitus

,

substance withdrawal syndrome

,

anatomical pathological conditions

,

mucopolysaccharidoses

,

multiple sclerosis

,

tracheal neoplasms

,

cardiomyopathies

,

dilated cardiomyopathy

,

,

acute lung injury

,

,

degloving injuries

,

squamous cell carcinoma

,

actinic keratosis

,

,

,

,

,

,

,

elbow tendinopathy

,

,

invasive fungal infections

,

,

,

,

,

bone marrow failure disorders

,

myelodysplastic syndromes

,

,

,

hematologic neoplasms

,

precursor cell lymphoblastic leukemia-lymphoma

,

multiple myeloma

,

,

bcr-abl positive chronic myelogenous leukemia

,

non-hodgkin lymphoma

,

plasma cell neoplasms

,

lymphoid leukemia

,

myeloproliferative disorders

,

,

type 1 diabetes mellitus

,

hematopoietic stem cell transplantation

,

myelodysplastic-myeloproliferative diseases

,

lung transplantation

,

,

chronic renal insufficiency

,

primary myelofibrosis

,

stem cell transplantation

,

,

follicular lymphoma

,

biphenotypic leukemia acute

,

,

,

prostatic neoplasms

,

periodontal diseases

,

myeloid leukemia chronic-phase

,

neoplasm metastasis

,

,

,

,

,

corneal transplantation

,

healthy volunteers/patients

,

,

acute kidney injury

,

idiopathic pulmonary fibrosis

,

pulmonary fibrosis

,

hip osteoarthritis

,

urinary incontinence

,

stress urinary incontinence

,

,

corneal diseases

,

sickle cell trait

,

pulmonary hypertension

,

chronic obstructive pulmonary disease

,

cystic fibrosis

,

,

giant cell tumor of bone

,

giant cell tumors

,

,

vocal cord paralysis

,

pharmacokinetics

,

replacement arthroplasty hip

,

prosthesis-related infections

,

drug-related side effects and adverse reactions

,

kidney transplantation

,

,

myeloid leukemia acute

,

myeloid leukemia

,

graft rejection

,

intervertebral disc degeneration

,

renal insufficiency

,

,

,

vascular diseases

,

,

,

kidney diseases

,

chronic kidney failure

,

heart transplantation

,

graft vs host disease

,

liver transplantation

,

,

spondylolisthesis

,

diabetes mellitus

,

wounds and injuries

,

spinal stenosis

,

alveolar bone loss

,

,

,

,

rotator cuff injuries

,

,

knee osteoarthritis

,

spinal diseases

,

immunosuppression therapy

,

anterior cruciate ligament injuries

,

communicable diseases

,

,

,

gingival recession

,

,

,

alveolar ridge augmentation

,

delayed graft function

,

reperfusion injury

,

bronchiolitis obliterans syndrome

,

cytomegalovirus infections

,

,

lymphoproliferative disorders

,

bone resorption

,

,

pathologic constriction

,

,

,

bronchiolitis obliterans

,

,

,

immunologic deficiency syndromes

,

pancreas transplantation

,

organ transplantation

,

,

,

,

breast neoplasms

,

,

,

epstein-barr virus infections

,

transplantation

,

pelvic organ prolapse

,

,

,

type 2 diabetes mellitus

,

herpesviridae infections

,

,

tibial fractures

,

,

tibial meniscus injuries

,

,

diabetes complications

,

x-linked combined immunodeficiency diseases

,

,

,

,

,

erectile dysfunction

,

,

peri-implantitis

,

,

respiratory tract infections

,

,

,

immune reconstitution

,

interstitial lung diseases

,

glomerular filtration rate

,

cardio-renal syndrome

,

retroperitoneal fibrosis

,

dna virus infections

,

periapical diseases

,

venous insufficiency

,

,

abdominal hernia

,

,

internal hernia

,

craniosynostoses

,

hidradenitis suppurativa

,

,

necrotizing fasciitis

,

,

,

intervertebral disc displacement

,

spinal cord diseases

,

,

,

dental implants

,

,

congenital heart defects

,

joint dislocations

,

chronic periodontitis

,

,

bone marrow diseases

,

patellar dislocation

,

shoulder impingement syndrome

,

immunoglobulin light-chain amyloidosis

,

liver cirrhosis

,

tricuspid valve insufficiency

,

shoulder dislocation

,

edentulous jaw partially

,

,

osteochondrosis

,

primary graft dysfunction

,

,

traumatic amputation

,

,

musculoskeletal diseases

,

tooth fractures

,

,

coronary artery disease

,

,

postoperative pain

,

medication adherence

,

,

,

neutropenic enterocolitis

,

,

,

laryngeal neoplasms

,

,

,

cartilage diseases

,

tracheal diseases

,

,

femoral fractures

,

,

plantar fasciitis

,

tetralogy of fallot

,

anterior cruciate ligament reconstruction

,

joint instability

,

tendon injuries

,

aortic valve disease

,

bone regeneration

,

,

magnetic resonance imaging

,

rotator cuff tear arthropathy

,

,

,

tissue adhesions

,

,

alveolar bone grafting

,

spinal cord compression

,

peripheral arterial disease

,

peripheral vascular diseases

,

,

stomatognathic diseases

,

renin-angiotensin system

,

coronary disease

,

myocardial ischemia

,

ovarian neoplasms

,

,

mental disorders

,

cognition disorders

,

pheochromocytoma

,

peroxisomal disorders

,

lysosomal storage diseases

,

,

mast-cell leukemia

,

blastic plasmacytoid dendritic cell neoplasm

,

promyelocytic leukemia acute

,

graft vs leukemia effect

,

mucopolysaccharidosis vi

,

insulin resistance

,

atherosclerosis

,

hepatitis b virus

,

liver neoplasms

,

anxiety disorders

,

depressive disorder

,

transplantation tolerance

,

pancreatic neoplasms

,

iron metabolism disorders

,

inborn errors metabolism

,

infectious bone diseases

,

,

nervous system diseases

,

rheumatic diseases

,

collagen diseases

,

,

,

bankart lesions

,

environmental biomarkers

,

genetic predisposition to disease

,

lens subluxation

,

renal artery obstruction

,

,

ununited fractures

,

meningomyelocele

,

spina bifida cystica

,

,

,

,

,

pulmonary valve insufficiency

,

compression fractures

,

,

,

,

,

,

refractive errors

,

,

injection site reaction

,

soft tissue injuries

,

,

,

pharyngeal neoplasms

,

,

tracheoesophageal fistula

,

athletic injuries

,

,

,

,

laryngeal diseases

,

laryngostenosis

,

,

,

,

shoulder injuries

,

,

tympanic membrane perforation

,

,

surgical amputation

,

,

tissue transplantation

,

,

,

heart valve diseases

,

,

furcation defects

,

brain neoplasms

,

soft tissue infections

,

,

,

,

,

chronic limb-threatening ischemia

,

cord blood stem cell transplantation

,

cone-rod dystrophies

,

hand transplantation

,

spondylarthropathies

,

preprosthetic oral surgical procedures

,

rheumatoid arthritis

,

gastroesophageal reflux

,

femoral neck fractures

,

dentofacial deformities

,

physiological stress

,

facial transplantation

,

hypoplastic left heart syndrome

,

caregiver burden

,

spinal cord neoplasms

,

failed back surgery syndrome

,

,

,

invasive pulmonary aspergillosis

,

,

radius fractures

,

wrist fractures

,

,

intestinal failure

,

hereditary congenital and neonatal diseases and abnormalities

,

,

,

langerhans-cell histiocytosis

,

gingival diseases

,

extracorporeal membrane oxygenation

,

dental pulp diseases

,

,

,

open-angle glaucoma

,

,

,

,

,

bone malalignment

,

spontaneous abortion

,

fetal growth retardation

,

,

prophylactic mastectomy

,

,

gender-affirming surgery

,

,

,

cold temperature

,

bacterial endocarditis

,

,

muscle weakness

,

muscular atrophy

,

postoperative period

,

,

periodontal guided tissue regeneration

,

preoperative exercise

,

nutritional and metabolic diseases

,

haploidentical transplantation

,

rectal neoplasms

,

dental implantation

,

,

huntington disease

,

,

guided tissue regeneration

,

urinary bladder neoplasms

,

urinary bladder diseases

,

,

pudendal neuralgia

,

angle class i malocclusion

,

diabetic angiopathies

,

cardiovascular diseases

,

glucose metabolism disorders

,

diabetic neuropathies

,

endocrine system diseases

,

,

,

pathologic processes

,

,

patient satisfaction

,

immediate dental implant loading

,

hepatocellular carcinoma

,

linear energy transfer

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