Apellis Pharmaceuticals - PharmaKB

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Company ReportsApellis Pharmaceuticals

Apellis Pharmaceuticals(APLS)

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Therapeutic Areas:

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Include Generics:

Trade Name	Drug Name	Approved	Patent Expires	Indication
Empaveli	Pegcetacoplan	2021-05-14	2026-2038	Paroxysmal hemoglobinuria
Syfovre	Pegcetacoplan	2023-02-17	2026-2038	Paroxysmal hemoglobinuria

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

beta-thalassemia

,

,

,

newborn respiratory distress syndrome

,

postoperative nausea and vomiting

,

,

viral hepatitis human

,

,

neurologic manifestations

,

brain neoplasms

,

,

,

biliary tract neoplasms

,

,

follicular lymphoma

,

,

microsatellite instability

,

squamous cell neoplasms

,

large cell carcinoma

,

chronic obstructive pulmonary disease

,

,

cholangiocarcinoma

,

,

mouth neoplasms

,

oropharyngeal neoplasms

,

laryngeal neoplasms

,

hypopharyngeal neoplasms

,

b-cell lymphoma marginal zone

,

mantle-cell lymphoma

,

endometrial neoplasms

,

transitional cell carcinoma

,

uterine cervical neoplasms

,

type 2 diabetes mellitus

,

diabetes mellitus

,

non-small-cell lung carcinoma

,

,

,

,

breast neoplasms

,

,

communicable diseases

,

chronic hepatitis c

,

,

,

,

,

triple negative breast neoplasms

,

neoplasm metastasis

,

colorectal neoplasms

,

stomach neoplasms

,

esophageal neoplasms

,

,

squamous cell carcinoma of head and neck

,

head and neck neoplasms

,

ovarian neoplasms

,

,

chronic hepatitis

,

,

,

squamous cell carcinoma

,

sleep initiation and maintenance disorders

,

,

clostridium infections

,

multiple myeloma

,

plasma cell neoplasms

,

hodgkin disease

,

,

ovarian epithelial carcinoma

,

migraine disorders

,

castration-resistant prostatic neoplasms

,

pancreatic neoplasms

,

,

essential hypertension

,

nasopharyngeal neoplasms

,

acquired immunodeficiency syndrome

,

,

chronic renal insufficiency

,

kidney diseases

,

hepatocellular carcinoma

,

general anesthesia

,

neuromuscular blockade

,

intraabdominal infections

,

urinary tract infections

,

malignant mesothelioma

,

,

postmenopausal osteoporosis

,

hypercholesterolemia

,

alzheimer disease

,

,

erectile dysfunction

,

renal cell carcinoma

,

surgical wound infection

,

bacterial skin diseases

,

bacterial infections

,

staphylococcal infections

,

,

immunologic deficiency syndromes

,

urinary bladder neoplasms

,

,

type 1 diabetes mellitus

,

cytomegalovirus infections

,

,

glucose metabolism disorders

,

metabolic diseases

,

endocrine system diseases

,

allergic rhinitis

,

,

allergic rhinitis seasonal

,

liver neoplasms

,

fallopian tube neoplasms

,

,

,

bacterial pneumonia

,

,

,

,

,

hepatic insufficiency

,

,

prostatic hyperplasia

,

,

,

cognitive dysfunction

,

,

,

prostatic neoplasms

,

plexiform neurofibroma

,

neurofibromatosis 1

,

hereditary breast and ovarian cancer syndrome

,

,

central nervous system neoplasms

,

nervous system neoplasms

,

rheumatoid arthritis

,

,

hip osteoarthritis

,

surgical blood loss

,

replacement arthroplasty hip

Decellularized dermal allograft

tooth extraction

,

dental implants

,

,

,

immunoglobulin light-chain amyloidosis

,

,

,

bone transplantation

,

,

neurogenic urinary bladder

,

,

blastic plasmacytoid dendritic cell neoplasm

,

,

,

interdigitating dendritic cell sarcoma

,

autoimmune diseases

,

duchenne muscular dystrophy

,

muscular dystrophies

,

merkel cell carcinoma

,

squamous cell neoplasms

,

immune system diseases

,

,

systemic scleroderma

,

systemic lupus erythematosus

,

monoclonal gammopathy of undetermined significance

,

cytomegalovirus

,

graft pancreatitis

,

osteochondrodysplasias

,

urinary bladder neck obstruction

,

bladder exstrophy

,

residual neoplasm

,

,

adenoviridae infections

,

end stage liver disease

,

,

,

,

hematologic diseases

,

,

congenital abnormalities

,

t-cell lymphoma

,

myelomonocytic leukemia chronic

,

aplastic anemia

,

b-cell lymphoma

,

,

refractory anemia with excess of blasts

,

,

tissue preservation

,

digeorge syndrome

,

waldenstrom macroglobulinemia

,

t-cell lymphoma peripheral

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

bone marrow transplantation

,

prolymphocytic leukemia

,

sezary syndrome

,

t-cell lymphoma cutaneous

,

sinus floor augmentation

,

homologous transplantation

,

,

large-cell lymphoma anaplastic

,

mycosis fungoides

,

myelomonocytic leukemia juvenile

,

severe combined immunodeficiency

,

sickle cell anemia

,

,

erythroblastic leukemia acute

,

paroxysmal hemoglobinuria

,

renal cell carcinoma

,

,

hairy cell leukemia

,

leukemia myeloid chronic atypical bcr-abl negative

,

polycythemia vera

,

kidney neoplasms

,

chronic disease

,

,

metabolic diseases

,

,

liver cirrhosis

,

edentulous mouth

,

megakaryoblastic leukemia acute

,

monocytic leukemia acute

,

myelomonocytic leukemia acute

,

plasma cell leukemia

,

immunoblastic lymphadenopathy

,

large granular lymphocytic leukemia

,

lymphomatoid granulomatosis

,

,

essential thrombocythemia

,

precancerous conditions

,

inborn genetic diseases

,

,

tracheal stenosis

,

cartilage fractures

,

maxillary sinusitis

,

,

prolymphocytic leukemia t-cell

,

islets of langerhans transplantation

,

basal cell carcinoma

,

basal cell neoplasms

,

extranodal nk-t-cell lymphoma

,

adult t-cell leukemia-lymphoma

,

intraocular lymphoma

,

,

hypoparathyroidism

,

refractory anemia

,

primary immunodeficiency diseases

,

metabolic syndrome

,

wiskott-aldrich syndrome

,

chronic granulomatous disease

,

hemoglobinopathies

,

,

philadelphia chromosome

,

insulin resistance

,

mucopolysaccharidosis i

,

liver neoplasms

,

wound infection

,

collagen diseases

,

peripheral nerve injuries

,

limbal stem cell deficiency

,

,

,

human influenza

,

acute lung injury

,

squamous cell carcinoma

,

respiratory aspiration

,

myocardial infarction

,

,

induction chemotherapy

,

autologous transplantation

,

,

myeloid sarcoma

,

,

neural tube defects

,

pathologic complete response

,

,

phenylketonurias

,

,

fanconi syndrome

,

diabetic nephropathies

,

iga glomerulonephritis

,

renal hypertension

,

acquired immunodeficiency syndrome

,

prolymphocytic leukemia b-cell

,

brain stem neoplasms

,

castleman disease

,

peripheral blood stem cell transplantation

,

diamond-blackfan anemia

,

hemoglobin sc disease

,

,

neutrophilic leukemia chronic

,

respiratory signs and symptoms

,

complement activation

,

experimental diabetes mellitus

,

substance withdrawal syndrome

,

anatomical pathological conditions

,

mucopolysaccharidoses

,

multiple sclerosis

,

,

plasmablastic lymphoma

,

tracheal neoplasms

,

cardiomyopathies

,

dilated cardiomyopathy

,

,

,

degloving injuries

,

actinic keratosis

,

,

,

,

,

,

elbow tendinopathy

,

,

,

organizing pneumonia

,

,

,

,

bone marrow failure disorders

,

hereditary angioedemas

,

connective tissue diseases

,

genetic skin diseases

,

skin and connective tissue diseases

,

epidermolysis bullosa

,

skin abnormalities

,

epidermolysis bullosa dystrophica

,

vesiculobullous skin diseases

,

myelodysplastic syndromes

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

hematologic neoplasms

,

multiple myeloma

,

non-hodgkin lymphoma

,

,

bcr-abl positive chronic myelogenous leukemia

,

,

hodgkin disease

,

myeloproliferative disorders

,

plasma cell neoplasms

,

b-cell chronic lymphocytic leukemia

,

lymphoid leukemia

,

hematopoietic stem cell transplantation

,

,

lung transplantation

,

myelodysplastic-myeloproliferative diseases

,

mantle-cell lymphoma

,

,

large b-cell lymphoma diffuse

,

burkitt lymphoma

,

primary myelofibrosis

,

biphenotypic leukemia acute

,

,

follicular lymphoma

,

reperfusion injury

,

,

myeloid leukemia chronic-phase

,

b-cell lymphoma marginal zone

,

large-cell lymphoma immunoblastic

,

myeloid leukemia accelerated phase

,

lymphoproliferative disorders

,

stem cell transplantation

,

prostatic neoplasms

,

,

,

musculoskeletal diseases

,

periodontal diseases

,

,

,

,

acute kidney injury

,

,

rheumatic diseases

,

,

neoplasm metastasis

,

,

,

corneal transplantation

,

healthy volunteers/patients

,

idiopathic pulmonary fibrosis

,

hip osteoarthritis

,

urinary incontinence

,

stress urinary incontinence

,

,

corneal diseases

,

sickle cell trait

,

pulmonary hypertension

,

chronic obstructive pulmonary disease

,

cystic fibrosis

,

,

giant cell tumor of bone

,

,

vocal cord paralysis

,

pharmacokinetics

,

replacement arthroplasty hip

,

prosthesis-related infections

,

drug-related side effects and adverse reactions

,

kidney transplantation

,

,

myeloid leukemia acute

,

graft rejection

,

intervertebral disc degeneration

,

myeloid leukemia

,

renal insufficiency

,

,

,

graft vs host disease

,

vascular diseases

,

,

chronic kidney failure

,

heart transplantation

,

,

liver transplantation

,

kidney diseases

,

diabetes mellitus

,

type 1 diabetes mellitus

,

spondylolisthesis

,

,

,

wounds and injuries

,

spinal stenosis

,

alveolar bone loss

,

rotator cuff injuries

,

,

anterior cruciate ligament injuries

,

,

knee osteoarthritis

,

spinal diseases

,

immunosuppression therapy

,

bronchiolitis obliterans syndrome

,

chronic renal insufficiency

,

,

alveolar ridge augmentation

,

gingival recession

,

,

,

delayed graft function

,

psychology rejection

,

communicable diseases

,

,

cytomegalovirus infections

,

bronchiolitis obliterans

,

bone resorption

,

,

,

pancreas transplantation

,

organ transplantation

,

type 2 diabetes mellitus

,

,

immunologic deficiency syndromes

,

,

pathologic constriction

,

breast neoplasms

,

diabetes complications

,

,

,

,

,

,

,

,

epstein-barr virus infections

,

transplantation

,

pelvic organ prolapse

,

,

herpesviridae infections

,

pulmonary fibrosis

,

x-linked combined immunodeficiency diseases

,

tibial fractures

,

magnetic resonance imaging

,

tibial meniscus injuries

,

peri-implantitis

,

,

,

,

,

,

,

,

abdominal hernia

,

erectile dysfunction

,

,

,

randomized controlled trials as topic

,

,

,

respiratory tract infections

,

,

,

immune reconstitution

,

glomerular filtration rate

,

cardio-renal syndrome

,

retroperitoneal fibrosis

,

dna virus infections

,

periapical diseases

,

venous insufficiency

,

,

,

internal hernia

,

craniosynostoses

,

hidradenitis suppurativa

,

,

necrotizing fasciitis

,

,

,

,

,

spinal cord diseases

,

,

,

intervertebral disc displacement

,

,

congenital heart defects

,

,

patellar dislocation

,

joint dislocations

,

chronic periodontitis

,

peripheral arterial disease

,

bone marrow diseases

,

tricuspid valve insufficiency

,

tracheal diseases

,

shoulder impingement syndrome

,

primary graft dysfunction

,

coronary artery disease

,

,

,

shoulder dislocation

,

edentulous jaw partially

,

,

osteochondrosis

,

,

,

traumatic amputation

,

,

tooth fractures

,

metabolic bone diseases

,

,

,

,

,

postoperative pain

,

medication adherence

,

,

,

neutropenic enterocolitis

,

,

,

laryngeal neoplasms

,

,

,

cartilage diseases

,

,

,

,

femoral fractures

,

ununited fractures

,

spinal dysraphism

,

,

,

plantar fasciitis

,

tetralogy of fallot

,

anterior cruciate ligament reconstruction

,

joint instability

,

tendon injuries

,

aortic valve disease

,

bone regeneration

,

injection site reaction

,

rotator cuff tear arthropathy

,

,

,

tissue adhesions

,

,

alveolar bone grafting

,

spinal cord compression

,

peripheral vascular diseases

,

,

stomatognathic diseases

,

,

renin-angiotensin system

,

coronary disease

,

myocardial ischemia

,

ovarian neoplasms

,

,

mental disorders

,

cognition disorders

,

pheochromocytoma

,

peroxisomal disorders

,

lysosomal storage diseases

,

,

,

mast-cell leukemia

,

promyelocytic leukemia acute

,

graft vs leukemia effect

,

mucopolysaccharidosis vi

,

atherosclerosis

,

hepatitis b virus

,

anxiety disorders

,

depressive disorder

,

transplantation tolerance

,

pancreatic neoplasms

,

adrenoleukodystrophy

,

iron metabolism disorders

,

infectious bone diseases

,

,

nervous system diseases

,

,

,

,

bankart lesions

,

environmental biomarkers

,

genetic predisposition to disease

,

lens subluxation

,

renal artery obstruction

,

,

meningomyelocele

,

,

klippel-feil syndrome

,

,

,

pulmonary valve insufficiency

,

compression fractures

,

,

,

,

refractive errors

,

,

soft tissue injuries

,

,

,

pharyngeal neoplasms

,

,

tracheoesophageal fistula

,

athletic injuries

,

,

laryngeal diseases

,

laryngostenosis

,

,

,

,

shoulder injuries

,

,

tympanic membrane perforation

,

,

surgical amputation

,

tissue transplantation

,

glomerulonephritis

,

,

,

heart valve diseases

,

,

furcation defects

,

brain neoplasms

,

soft tissue infections

,

,

,

,

,

chronic limb-threatening ischemia

,

cord blood stem cell transplantation

,

cone-rod dystrophies

,

hand transplantation

,

spondylarthropathies

,

preprosthetic oral surgical procedures

,

rheumatoid arthritis

,

gastroesophageal reflux

,

femoral neck fractures

,

dentofacial deformities

,

physiological stress

,

facial transplantation

,

hypoplastic left heart syndrome

,

caregiver burden

,

spinal cord neoplasms

,

failed back surgery syndrome

,

,

invasive pulmonary aspergillosis

,

,

radius fractures

,

wrist fractures

,

,

intestinal failure

,

hereditary congenital and neonatal diseases and abnormalities

,

,

,

langerhans-cell histiocytosis

,

gingival diseases

,

extracorporeal membrane oxygenation

,

dental pulp diseases

,

,

open-angle glaucoma

,

,

,

,

bone malalignment

,

spontaneous abortion

,

fetal growth retardation

,

,

prophylactic mastectomy

,

,

gender-affirming surgery

,

,

,

cold temperature

,

bacterial endocarditis

,

,

muscle weakness

,

muscular atrophy

,

postoperative period

,

,

periodontal guided tissue regeneration

,

preoperative exercise

,

nutritional and metabolic diseases

,

haploidentical transplantation

,

rectal neoplasms

,

dental implantation

,

,

huntington disease

,

,

guided tissue regeneration

,

urinary bladder neoplasms

,

urinary bladder diseases

,

,

pudendal neuralgia

,

angle class i malocclusion

,

diabetic angiopathies

,

cardiovascular diseases

,

glucose metabolism disorders

,

diabetic neuropathies

,

endocrine system diseases

,

,

pathologic processes

,

,

patient satisfaction

,

hepatocellular carcinoma

,

linear energy transfer

,

aortic valve stenosis

,

aortic valve insufficiency

,

mitral valve insufficiency

,

abdominal aortic aneurysm

,

,

aortic aneurysm

,

ascending aorta aneurysm

,

patella fracture

,

airway remodeling

,

spinal cord injuries

,

thyroid diseases

,

parathyroid diseases

,

,

immune tolerance

,

organ preservation

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