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Company ReportsAmylyx Pharmaceuticals

Amylyx Pharmaceuticals(AMLX)

Amylyx Pharmaceuticals, Inc is a biopharmaceutical company headquartered in Cambridge, Massachusetts. Amylyx is best known for AMX0035, an experimental therapy for amyotrophic lateral sclerosis. AMX0035 was approved for medical use in Canada as Albrioza, in June 2022, and in the United States, as Relyvrio, in September 2022.

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Trade Name	Drug Name	Approved	Patent Expires	Indication
Relyvrio	Phenylbutyrate, Taurursodiol	2022-09-29		Ornithine carbamoyltransferase deficiency disease , Carbamoyl-phosphate synthase i deficiency disease , Citrullinemia , Amyotrophic lateral sclerosis

Clinical Trials

Therapeutic Areas:

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Drug Name

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Phase 2

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Indication

inborn errors lipid metabolism

,

multiple acyl coenzyme a dehydrogenase deficiency

alzheimer disease

,

central nervous system diseases

,

nervous system diseases

,

spinal cord diseases

,

tdp-43 proteinopathies

,

neuromuscular diseases

,

,

wolfram syndrome

,

amyotrophic lateral sclerosis

,

motor neuron disease

,

,

neurodegenerative diseases

,

parkinsonian disorders

,

progressive supranuclear palsy

,

Sodium phenylbutyrate

inborn errors lipid metabolism

,

multiple acyl coenzyme a dehydrogenase deficiency

Ursodoxicoltaurine

alzheimer disease

,

central nervous system diseases

,

nervous system diseases

,

spinal cord diseases

,

tdp-43 proteinopathies

,

neuromuscular diseases

,

,

wolfram syndrome

,

amyotrophic lateral sclerosis

,

motor neuron disease

,

,

neurodegenerative diseases

,

parkinsonian disorders

,

progressive supranuclear palsy

,

hepatic insufficiency

,

renal insufficiency

,

castration-resistant prostatic neoplasms

,

,

,

,

,

unknown primary neoplasms

,

immunomodulation

,

gram-positive bacterial infections

,

t-cell lymphoma peripheral

,

,

merkel cell carcinoma

,

mycosis fungoides

,

clear cell sarcoma

,

myelodysplastic syndromes

,

,

,

pulmonary sarcoidosis

,

lyme neuroborreliosis

,

hypertriglyceridemia

,

,

granuloma annulare

,

mycobacterium avium complex

,

thoracic neoplasms

,

pelvic neoplasms

,

,

,

brain neoplasms

,

stomach neoplasms

,

,

triple negative breast neoplasms

,

head and neck neoplasms

,

urinary bladder neoplasms

,

multiple myeloma

,

neoplasm metastasis

,

ovarian neoplasms

,

thyroid neoplasms

,

,

plasma cell neoplasms

,

small cell lung carcinoma

,

ovarian epithelial carcinoma

,

esophageal neoplasms

,

borrelia infections

,

endometrial neoplasms

,

thyroid diseases

,

keratoconjunctivitis sicca

,

dry eye syndromes

,

uveal neoplasms

,

respiratory syncytial viruses

,

,

,

transitional cell carcinoma

,

kidney diseases

,

small cell carcinoma

,

adenocarcinoma of lung

,

large-cell lymphoma anaplastic

,

,

,

pheochromocytoma

,

,

healthcare-associated pneumonia

,

systemic lupus erythematosus

,

alopecia areata

,

,

,

fallopian tube neoplasms

,

peritoneal neoplasms

,

oligodendroglioma

,

,

hemangioblastoma

,

urogenital neoplasms

,

,

central nervous system neoplasms

,

nervous system neoplasms

,

,

neurofibromatosis 1

,

neurofibromatoses

,

,

germ cell and embryonal neoplasms

,

carcinoid tumor

,

urethral neoplasms

,

ureteral neoplasms

,

alveolar soft part sarcoma

,

,

polycystic kidney diseases

,

autosomal dominant polycystic kidney

,

,

cholangiocarcinoma

,

gene rearrangement

,

lobular carcinoma

,

plasma cell leukemia

,

medulloblastoma

,

,

rhabdomyosarcoma

,

diffuse intrinsic pontine glioma

,

intraductal carcinoma noninfiltrating

,

b-cell lymphoma

,

cutaneous lupus erythematosus

,

keratoconjunctivitis

,

,

respiratory tract infections

,

,

,

,

hidradenitis suppurativa

,

,

meningococcal infections

,

neoadjuvant therapy

,

diabetes mellitus

,

type 1 diabetes mellitus

,

,

multidrug-resistant tuberculosis

,

von hippel-lindau disease

,

,

,

neurodermatitis

,

,

urologic neoplasms

,

urologic diseases

,

neoplasms by site

,

glandular and epithelial neoplasms

,

,

,

benign fibrous histiocytoma

,

,

malignant fibrous histiocytoma

,

myeloid leukemia accelerated phase

,

,

malignant mesothelioma

,

,

urinary bladder diseases

,

adrenal cortex neoplasms

,

adrenocortical carcinoma

,

second primary neoplasms

,

pulmonary tuberculosis

,

hematologic neoplasms

,

amyotrophic lateral sclerosis

,

motor neuron disease

,

mouth neoplasms

,

,

penile neoplasms

,

plexiform neurofibroma

,

,

testicular neoplasms

,

solitary fibrous tumors

,

,

hemangiopericytoma

,

male urogenital diseases

,

urogenital diseases

,

adenoid cystic carcinoma

,

,

hemangiosarcoma

,

systemic scleroderma

,

diffuse scleroderma

,

,

,

post-acute covid-19 syndrome

,

,

colorectal neoplasms

,

,

atopic dermatitis

,

,

,

,

kidney neoplasms

,

prostatic neoplasms

,

squamous cell carcinoma

,

liver neoplasms

,

pancreatic neoplasms

,

hepatocellular carcinoma

,

,

psoriatic arthritis

,

squamous cell neoplasms

,

squamous cell carcinoma of head and neck

,

,

male breast neoplasms

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

lymphoid leukemia

,

myeloid leukemia chronic-phase

,

juvenile arthritis

,

,

,

bacterial pneumonia

,

,

mycobacterium avium-intracellulare infection

,

immune system diseases

,

inborn genetic diseases

,

genetic skin diseases

,

eczematous skin diseases

,

hypersensitivity

,

immediate hypersensitivity

,

islet cell carcinoma

,

ankylosing spondylitis

,

bacterial infections

,

pancreatic ductal carcinoma

,

,

,

febrile neutropenia

,

,

mycobacterium infections

,

adenosquamous carcinoma

,

large cell carcinoma

,

nervous system diseases

,

optic nerve diseases

,

disease progression

,

cardiovascular diseases

,

immunologic deficiency syndromes

,

breast neoplasms

,

healthy volunteers/patients

,

,

renal cell carcinoma

,

non-small-cell lung carcinoma

,

,

,

rheumatoid arthritis

,

,

,

,

,

acquired immunodeficiency syndrome

,

communicable diseases

,

bcr-abl positive chronic myelogenous leukemia

,

,

ulcerative colitis

,

,

,

myeloid leukemia

,

neuroendocrine tumors

,

gastrointestinal stromal tumors

,

non-hodgkin lymphoma

,

kidney transplantation

,

philadelphia chromosome

,

islet cell adenoma

,

intraabdominal infections

,

mantle-cell lymphoma

,

,

spondylarthritis

,

,

gastrointestinal neoplasms

,

digestive system neoplasms

,

,

,

,

,

,

ventilator-associated pneumonia

,

chronic hepatitis c

,

,

axial spondyloarthritis

,

,

premature birth

,

bacterial vaginosis

,

vaginal diseases

,

,

infectious skin diseases

,

soft tissue infections

,

,

,

community-acquired infections

,

staphylococcal infections

,

,

hypercholesterolemia

,

coronary disease

,

coronary artery disease

,

myocardial ischemia

,

,

bacterial skin diseases

,

,

asymptomatic infections

,

,

,

respiratory tract diseases

Phenylbutanoic acid

inborn errors lipid metabolism

,

multiple acyl coenzyme a dehydrogenase deficiency

alzheimer disease

,

central nervous system diseases

,

nervous system diseases

,

spinal cord diseases

,

tdp-43 proteinopathies

,

neuromuscular diseases

,

,

wolfram syndrome

,

amyotrophic lateral sclerosis

,

motor neuron disease

,

,

neurodegenerative diseases

,

parkinsonian disorders

,

progressive supranuclear palsy

,

vascular stiffness

,

,

huntington disease

,

ulcerative colitis

,

,

,

,

diabetes mellitus

,

cardiomyopathies

,

familial amyloid neuropathies

,

type 1 diabetes mellitus

,

alzheimer disease

,

central nervous system diseases

,

nervous system diseases

,

spinal cord diseases

,

tdp-43 proteinopathies

,

neuromuscular diseases

,

multiple sclerosis

,

chronic progressive multiple sclerosis

,

,

wolfram syndrome

,

,

amyotrophic lateral sclerosis

,

motor neuron disease

,

,

,

neurodegenerative diseases

,

liver cirrhosis

,

,

,

biliary liver cirrhosis

,

,

parkinsonian disorders

,

progressive supranuclear palsy

,

,

,

,

cholecystolithiasis

,

type 2 diabetes mellitus

,

insulin resistance

,

disease progression

,

immunoglobulin light-chain amyloidosis

,

amyloid neuropathies

,

endoplasmic reticulum stress

,

,

cystic fibrosis

,

myeloproliferative disorders

,

myelodysplastic-myeloproliferative diseases

,

parkinson disease

,

intestinal neoplasms

,

color vision defects

,

healthy volunteers/patients

,

,

inclusion body myositis

,

,

,

neurodevelopmental disorders

,

,

,

,

,

,

myelodysplastic syndromes

,

,

cystic fibrosis

,

,

muscular atrophy

,

spinal muscular atrophy

,

,

myeloid leukemia acute

,

myeloid leukemia

,

tdp-43 proteinopathies

,

,

pulmonary tuberculosis

,

hepatic encephalopathy

,

spinal muscular atrophies of childhood

,

inborn errors metabolism

,

inborn errors amino acid metabolism

,

brain neoplasms

,

prostatic neoplasms

,

,

multiple myeloma

,

plasma cell neoplasms

,

,

beta-thalassemia

,

,

,

acquired immunodeficiency syndrome

,

liver cirrhosis

,

alpha 1-antitrypsin deficiency

,

pyruvate dehydrogenase complex deficiency disease

,

stomach neoplasms

,

head and neck neoplasms

,

lymphoproliferative disorders

,

epstein-barr virus infections

,

argininosuccinic aciduria

,

,

mucinous adenocarcinoma

,

colonic neoplasms

,

,

rectal neoplasms

,

cystadenocarcinoma

,

central nervous system diseases

,

nervous system diseases

,

spinal cord diseases

,

neuromuscular diseases

,

,

spinocerebellar degenerations

,

spinocerebellar ataxias

,

machado-joseph disease

,

cerebellar ataxia

,

huntington disease

,

corticobasal degeneration

,

wolfram syndrome

,

inborn errors lipid metabolism

,

multiple acyl coenzyme a dehydrogenase deficiency

,

amyotrophic lateral sclerosis

,

motor neuron disease

,

,

intrahepatic cholestasis

,

neurodegenerative diseases

,

inborn genetic diseases

,

,

maple syrup urine disease

,

,

parkinsonian disorders

,

progressive supranuclear palsy

,

,

inborn urea cycle disorders

,

pseudobulbar palsy

,

alzheimer disease

,

diabetes mellitus

,

,

,

insulin resistance

,

,

,

traumatic brain injuries

,

type 2 diabetes mellitus

,

,

,

,

vascular dementia

,

,

lewy body disease

,

hyperhomocysteinemia

,

vitamin b 12 deficiency

,

,

frontotemporal dementia

,

primary progressive aphasia

,

pick disease of the brain

,

cognitive dysfunction

,

iron deficiencies

,

,

health behavior

,

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