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Company ReportsAlexion Pharmaceuticals

Alexion Pharmaceuticals(ALXN)

Alexion Pharmaceuticals is an American pharmaceutical company headquartered in Boston, Massachusetts that specializes in orphan drugs to treat rare diseases. It became an independent subsidiary of AstraZeneca in 2021.

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Financial

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Revenue by Drug

Marketed Drugs

Therapeutic Areas:

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Classification:

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Include Generics:

Trade Name	Drug Name	Approved	Patent Expires	Indication
Kanuma	Sebelipase alfa	2015-12-08		Inborn errors lipid metabolism
Soliris	Eculizumab	2007-03-16		Paroxysmal hemoglobinuria , Atypical hemolytic uremic syndrome
Strensiq	Asfotase alfa	2015-10-23		Hypophosphatasia
Ultomiris	Ravulizumab	2018-12-21		Paroxysmal hemoglobinuria, Atypical hemolytic uremic syndrome

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

hypophosphatasia

Sebelipase alfa

,

cholesterol ester storage disease

,

,

failure to thrive

healthy volunteers/patients

,

,

end stage liver disease

,

kidney diseases

,

glomerulonephritis

,

membranoproliferative glomerulonephritis

,

,

,

chronic kidney failure

,

,

anti-neutrophil cytoplasmic antibody-associated vasculitis

,

,

,

multiple organ failure

,

diabetes mellitus

,

thrombocytopenia

,

complement activation

,

renal insufficiency

,

wounds and injuries

,

reperfusion injury

,

chronic renal insufficiency

,

hemolytic anemia autoimmune

,

,

antiphospholipid syndrome

,

macular degeneration

,

geographic atrophy

,

,

dermatomyositis

,

autoimmune diseases

,

neuromyelitis optica

,

myasthenia gravis

,

kidney transplantation

,

muscle weakness

,

vascular diseases

,

thrombotic microangiopathies

,

guillain-barre syndrome

,

delayed graft function

,

escherichia coli infections

,

,

left ventricular dysfunction

,

ventricular dysfunction

,

shiga-toxigenic escherichia coli

,

,

,

malignant hypertension

,

hypertensive crisis

,

phenylketonurias

,

paroxysmal hemoglobinuria

,

,

,

,

hemolytic-uremic syndrome

,

atypical hemolytic uremic syndrome

,

,

,

coronavirus infections

,

hypophosphatasia

,

respiratory distress syndrome

,

,

acute lung injury

,

viral pneumonia

,

,

newborn respiratory distress syndrome

,

,

protein-losing enteropathies

,

intestinal diseases

,

,

lymphangiectasis

,

intestinal lymphangiectasis

,

,

disease progression

,

intestinal obstruction

,

,

allergic fungal sinusitis

,

,

healthy volunteers/patients

,

,

hepatic insufficiency

,

renal insufficiency

,

glomerulonephritis

,

membranoproliferative glomerulonephritis

,

macular degeneration

,

geographic atrophy

,

,

paroxysmal hemoglobinuria

,

,

Mycophenolate sodium

kidney transplantation

,

,

focal segmental glomerulosclerosis

Calcium carbonate

,

postmenopausal osteoporosis

kidney transplantation

,

hereditary angioedemas

,

graft rejection

Antithrombin iii

primary myelofibrosis

,

healthy volunteers/patients

,

pancreatic neoplasms

,

uterine cervical neoplasms

,

autistic disorder

,

autism spectrum disorder

,

pervasive child development disorders

,

,

central nervous system neoplasms

,

nervous system neoplasms

,

non-small-cell lung carcinoma

,

breast neoplasms

,

,

,

,

colorectal neoplasms

,

alzheimer disease

,

ovarian neoplasms

,

b-cell lymphoma

,

small cell lung carcinoma

,

,

,

,

stomach neoplasms

,

,

ulcerative colitis

,

,

,

macular degeneration

,

,

hepatocellular carcinoma

,

renal cell carcinoma

,

triple negative breast neoplasms

,

ovarian epithelial carcinoma

,

large b-cell lymphoma diffuse

,

follicular lymphoma

,

lupus nephritis

,

,

,

non-hodgkin lymphoma

,

wet macular degeneration

,

,

,

liver neoplasms

,

urinary bladder neoplasms

,

peritoneal neoplasms

,

colonic neoplasms

,

head and neck neoplasms

,

b-cell chronic lymphocytic leukemia

,

lymphoid leukemia

,

paroxysmal hemoglobinuria

,

,

,

,

squamous cell carcinoma

,

fallopian tube neoplasms

,

transitional cell carcinoma

,

neoplasm metastasis

,

kidney diseases

,

multiple sclerosis

,

chronic progressive multiple sclerosis

,

,

retinal vein occlusion

,

,

,

hemolytic anemia

,

hemolytic-uremic syndrome

,

atypical hemolytic uremic syndrome

,

,

systemic lupus erythematosus

,

nephrotic syndrome

,

,

lipoid nephrosis

,

,

ischemic stroke

,

,

,

esophageal squamous cell carcinoma

,

esophageal neoplasms

,

squamous cell carcinoma of head and neck

,

human influenza

,

prostatic neoplasms

,

castration-resistant prostatic neoplasms

,

urologic neoplasms

,

thyroid neoplasms

,

neuroendocrine carcinoma

,

papillary thyroid cancer

,

thyroid diseases

,

disease progression

,

,

chronic hepatitis b

,

,

chronic hepatitis

,

,

,

giant cell arteritis

,

polymyalgia rheumatica

,

membranous glomerulonephritis

,

respiratory tract diseases

,

germ cell and embryonal neoplasms

,

,

respiratory tract neoplasms

,

bronchogenic carcinoma

,

thoracic neoplasms

,

bronchial diseases

,

neoplasms by histologic type

,

neoplasms by site

,

nerve tissue neoplasms

,

ankylosing spondylitis

,

spondylarthritis

,

,

,

,

huntington disease

,

geographic atrophy

,

,

myasthenia gravis

,

muscle weakness

,

neuromyelitis optica

,

relapsing-remitting multiple sclerosis

,

guillain-barre syndrome

,

autoimmune diseases of the nervous system

,

hashimoto disease

,

,

partial epilepsies

,

rectal neoplasms

,

mucinous adenocarcinoma

,

ductal carcinoma breast

,

inflammatory breast neoplasms

,

bcr-abl positive chronic myelogenous leukemia

,

disability evaluation

,

cognition disorders

,

hemolytic anemia autoimmune

,

endometrial neoplasms

,

iga glomerulonephritis

,

non-muscle invasive bladder neoplasms

,

choroidal neovascularization

,

,

retinal neovascularization

,

pathologic neovascularization

,

,

diabetic nephropathies

,

myocardial infarction

,

hypersensitivity

,

,

,

renal tubular acidosis

,

,

,

fetal growth retardation

,

placenta diseases

cardiovascular diseases

non-hodgkin lymphoma

,

b-cell chronic lymphocytic leukemia

,

,

,

t-cell lymphoma

,

hodgkin disease

,

follicular lymphoma

,

b-cell lymphoma

,

lymphoid leukemia

healthy volunteers/patients

,

pancreatic neoplasms

,

myelodysplastic-myeloproliferative diseases

,

leukemia myeloid chronic atypical bcr-abl negative

,

,

,

cutaneous malignant melanoma

,

myeloid sarcoma

,

,

medication adherence

,

second primary neoplasms

,

ovarian epithelial carcinoma

,

,

,

multiple myeloma

,

follicular lymphoma

,

mantle-cell lymphoma

,

biphenotypic leukemia acute

,

t-cell lymphoma

,

neoplasm metastasis

,

ovarian neoplasms

,

large b-cell lymphoma diffuse

,

eyelid neoplasms

,

t-cell lymphoma peripheral

,

myeloid leukemia chronic-phase

,

,

myelomonocytic leukemia acute

,

fallopian tube neoplasms

,

medulloblastoma

,

triple negative breast neoplasms

,

,

b-cell lymphoma marginal zone

,

burkitt lymphoma

,

squamous cell carcinoma of head and neck

,

squamous cell carcinoma

,

diabetes mellitus

,

castration-resistant prostatic neoplasms

,

,

myeloid leukemia accelerated phase

,

refractory anemia with excess of blasts

,

,

primitive neuroectodermal tumors

,

neuroectodermal tumors

,

renal cell carcinoma

,

,

brain neoplasms

,

extranodal nk-t-cell lymphoma

,

waldenstrom macroglobulinemia

,

large-cell lymphoma anaplastic

,

large-cell lymphoma immunoblastic

,

,

,

hepatocellular carcinoma

,

liver neoplasms

,

residual neoplasm

,

,

islet cell adenoma

,

,

nervous system neoplasms

,

primitive neuroectodermal tumors peripheral

,

,

,

oligodendroglioma

,

,

ganglioneuroblastoma

,

ovarian hyperstimulation syndrome

,

,

sezary syndrome

,

immunoblastic lymphadenopathy

,

mycosis fungoides

,

adult t-cell leukemia-lymphoma

,

intraocular lymphoma

,

t-cell lymphoma cutaneous

,

plasmablastic lymphoma

,

t-cell leukemia

,

lymphomatoid granulomatosis

,

sickle cell anemia

,

,

systemic lupus erythematosus

,

biliary tract neoplasms

,

immunologic deficiency syndromes

,

hematopoietic stem cell transplantation

,

erythroblastic leukemia acute

,

pathologic complete response

,

head and neck neoplasms

,

wounds and injuries

,

,

,

thyroid neoplasms

,

papillary thyroid cancer

,

thyroid diseases

,

follicular adenocarcinoma

,

papillary carcinoma

,

type 1 diabetes mellitus

,

urinary retention

,

,

urinary tract infections

,

pelvic organ prolapse

,

,

male breast neoplasms

,

pulmonary alveolar proteinosis

,

hematologic diseases

,

clostridium infections

,

bone marrow transplantation

,

,

basal cell carcinoma

,

merkel cell carcinoma

,

basal cell neoplasms

,

hypersensitivity

,

graft vs host disease

,

prolymphocytic leukemia

,

precursor cell lymphoblastic leukemia-lymphoma

,

lymphoid leukemia

,

,

,

,

non-hodgkin lymphoma

,

myeloproliferative disorders

,

philadelphia chromosome

,

hematologic neoplasms

,

bcr-abl positive chronic myelogenous leukemia

,

hodgkin disease

,

non-small-cell lung carcinoma

,

geographic atrophy

,

,

breast neoplasms

,

plasma cell neoplasms

,

b-cell lymphoma

,

prostatic neoplasms

,

b-cell chronic lymphocytic leukemia

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

rhabdomyosarcoma

,

primary myelofibrosis

,

central nervous system neoplasms

,

,

,

mucocutaneous lymph node syndrome

,

,

,

,

,

macular degeneration

,

,

spinal cord neoplasms

,

,

neuroendocrine tumors

,

muscle spasticity

,

colorectal neoplasms

,

induction chemotherapy

,

venous thromboembolism

,

thromboembolism

,

,

,

,

ischemic stroke

,

,

,

brain stem neoplasms

,

,

invasive hydatidiform mole

,

,

nephrotic syndrome

,

,

pulmonary embolism

,

,

autonomic nervous system diseases

,

,

primary dysautonomias

,

familial dysautonomia

,

hydatidiform mole

,

gestational trophoblastic disease

,

choriocarcinoma

,

trophoblastic neoplasms

,

juvenile arthritis

,

kidney neoplasms

,

,

,

myeloid leukemia acute

,

myeloid leukemia

,

myelodysplastic syndromes

,

,

myelomonocytic leukemia chronic

,

myelomonocytic leukemia juvenile

,

,

,

rheumatoid arthritis

,

,

,

aplastic anemia

,

,

inflammatory bowel diseases

,

ulcerative colitis

,

,

,

kidney diseases

,

,

iga glomerulonephritis

,

child mortality

,

growth and development

,

critical illness

,

premature birth

,

intestinal diseases

,

lupus nephritis

,

,

kidney transplantation

,

,

plantar fasciitis

,

,

,

,

,

acute coronary syndrome

,

coronary artery disease

,

percutaneous coronary intervention

,

,

gastrointestinal diseases

,

cardiovascular diseases

,

gastrointestinal stromal tumors

,

,

esophageal neoplasms

,

,

chronic hepatitis b

,

,

chronic hepatitis

,

,

thrombocytopenia

,

germ cell and embryonal neoplasms

,

,

retinal neoplasms

,

phenylketonurias

,

heart disease risk factors

,

stomatognathic diseases

,

endocrine system diseases

,

autoimmune diseases

,

cognitive dysfunction

,

neurocognitive disorders

,

major depressive disorder

,

depressive disorder

,

,

type 2 diabetes mellitus

,

chronic periodontitis

,

,

,

,

equinus deformity

,

,

,

,

drug-related side effects and adverse reactions

,

digestive system diseases

,

,

wasting syndrome

,

child nutrition disorders

,

,

severe acute malnutrition

coronary artery disease

,

cardiopulmonary bypass

,

coronary artery bypass

,

precursor cell lymphoblastic leukemia-lymphoma

,

lymphoid leukemia

,

graft vs host disease

,

pancreatic neoplasms

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