Alexion Pharmaceuticals - PharmaKB

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Company ReportsAlexion Pharmaceuticals

Alexion Pharmaceuticals(ALXN)

Alexion Pharmaceuticals is an American pharmaceutical company headquartered in Boston, Massachusetts that specializes in orphan drugs to treat rare diseases. It became an independent subsidiary of AstraZeneca in 2021.

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Marketed Drugs

Clinical Trials

Financial

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Company Revenue

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Annual

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Projections

*Quarterly sales USD (in millions)

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Revenue by Drug

Marketed Drugs

Therapeutic Areas:

All

Classification:

All

Include Generics:

Trade Name	Drug Name	Approved	Patent Expires	Indication
Kanuma	Sebelipase alfa	2015-12-08		Inborn errors lipid metabolism
Soliris	Eculizumab	2007-03-16		Paroxysmal hemoglobinuria , Myasthenia gravis , Atypical hemolytic uremic syndrome
Strensiq	Asfotase alfa	2015-10-23		Hypophosphatasia
Ultomiris	Ravulizumab	2018-12-21		Paroxysmal hemoglobinuria, Atypical hemolytic uremic syndrome

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

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Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

hypophosphatasia

Sebelipase alfa

,

cholesterol ester storage disease

,

,

failure to thrive

glomerulonephritis

,

membranoproliferative glomerulonephritis

,

,

end stage liver disease

,

,

atypical hemolytic uremic syndrome

,

,

kidney transplantation

,

kidney diseases

,

,

anti-neutrophil cytoplasmic antibody-associated vasculitis

,

,

,

,

complement activation

,

psychology rejection

,

chronic renal insufficiency

,

hemolytic anemia autoimmune

,

,

macular degeneration

,

geographic atrophy

,

,

,

hemolytic-uremic syndrome

,

myasthenia gravis

,

neuromyelitis optica

,

muscle weakness

,

delayed graft function

,

guillain-barre syndrome

,

left ventricular dysfunction

,

ventricular dysfunction

,

escherichia coli infections

,

shiga-toxigenic escherichia coli

,

phenylketonurias

,

paroxysmal hemoglobinuria

,

,

,

respiratory distress syndrome

,

,

acute lung injury

,

hypophosphatasia

,

severe acute respiratory syndrome

,

viral pneumonia

,

,

newborn respiratory distress syndrome

,

,

disease progression

,

healthy volunteers/patients

,

hepatic insufficiency

,

renal insufficiency

,

glomerulonephritis

,

membranoproliferative glomerulonephritis

,

geographic atrophy

,

paroxysmal hemoglobinuria

,

,

,

Mycophenolate sodium

graft vs host disease

,

immune system diseases

healthy volunteers/patients

b-cell chronic lymphocytic leukemia

,

,

hodgkin disease

,

b-cell lymphoma

,

t-cell lymphoma cutaneous

,

bronchiolitis obliterans syndrome

,

,

t-cell lymphoma

,

follicular lymphoma

,

,

large-cell lymphoma anaplastic

,

t-cell lymphoma peripheral

,

non-hodgkin lymphoma

coronary artery disease

,

cardiopulmonary bypass

,

coronary artery bypass

hepatitis b virus

,

chronic hepatitis b

,

,

,

Choline alfoscerate

,

,

pheochromocytoma

,

,

,

malignant carcinoid syndrome

,

carcinoid heart disease

,

serotonin syndrome

,

,

liver neoplasms

,

neoplasm metastasis

,

neuroendocrine tumors

,

carcinoid tumor

,

,

neuroendocrine carcinoma

,

restless legs syndrome

,

psychomotor agitation

,

,

myocardial infarction

,

uterine cervical neoplasms

,

,

hematologic diseases

,

blood protein disorders

,

plasma cell neoplasms

,

paraproteinemias

,

corneal diseases

,

drug resistance

,

precursor cell lymphoblastic leukemia-lymphoma

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

,

synovial sarcoma

,

falciparum malaria

,

heat stress disorders

,

,

combat disorders

,

traumatic stress disorders

,

,

healthy volunteers/patients

,

,

focal segmental glomerulosclerosis

,

sickle cell anemia

,

beta-thalassemia

,

,

sickle cell trait

,

,

human influenza

,

influenza in birds

,

multiple myeloma

,

cardiovascular diseases

,

breast neoplasms

,

,

rheumatoid arthritis

,

,

,

mucinous adenocarcinoma

,

ductal carcinoma breast

,

inflammatory breast neoplasms

,

,

,

glucose metabolism disorders

,

metabolic diseases

,

diabetes mellitus

,

vascular diseases

,

,

metabolic syndrome

,

endocrine system diseases

,

hypertriglyceridemia

,

,

atrial fibrillation

,

,

tick-borne encephalitis

,

,

,

,

mitochondrial diseases

,

mitral valve insufficiency

,

,

,

non-alcoholic fatty liver disease

,

,

wasting syndrome

,

,

,

,

,

cytomegalovirus infections

,

communicable diseases

,

gastrointestinal diseases

,

digestive system diseases

,

depressive disorder

,

lymphoid leukemia

,

squamous cell carcinoma

,

b-cell chronic lymphocytic leukemia

,

follicular lymphoma

,

interdigitating dendritic cell sarcoma

,

squamous cell neoplasms

,

adenosquamous carcinoma

,

precursor cell lymphoblastic leukemia-lymphoma

,

philadelphia chromosome

,

myelodysplastic syndromes

,

graft vs host disease

,

gata2 deficiency

,

neoplasm metastasis

,

small cell carcinoma

,

neuroendocrine carcinoma

,

squamous cell carcinoma of head and neck

,

mouth neoplasms

,

gastrointestinal neoplasms

,

adenoviridae infections

,

,

,

,

,

,

pancreatic neoplasms

,

,

non-hodgkin lymphoma

,

large b-cell lymphoma diffuse

,

ovarian neoplasms

,

non-small-cell lung carcinoma

,

,

serous cystadenocarcinoma

,

b-cell lymphoma

,

colorectal neoplasms

,

myeloid leukemia acute

,

prostatic neoplasms

,

immunoglobulin light-chain amyloidosis

,

,

hematologic neoplasms

,

t-cell lymphoma

,

t-cell lymphoma peripheral

,

cholangiocarcinoma

,

malignant mesothelioma

,

,

,

pancreatic ductal carcinoma

,

ovarian epithelial carcinoma

,

,

triple negative breast neoplasms

,

myeloid leukemia

,

head and neck neoplasms

,

anti-neutrophil cytoplasmic antibody-associated vasculitis

,

breast neoplasms

,

multiple myeloma

,

plasma cell neoplasms

1

2

3

4

5

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