Alexion Pharmaceuticals - PharmaKB

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Company ReportsAlexion Pharmaceuticals

Alexion Pharmaceuticals(ALXN)

Alexion Pharmaceuticals is an American pharmaceutical company headquartered in Boston, Massachusetts that specializes in orphan drugs to treat rare diseases. It became an independent subsidiary of AstraZeneca in 2021.

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Marketed Drugs

Clinical Trials

Financial

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Company Revenue

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Annual

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Projections

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Revenue by Drug

Marketed Drugs

Therapeutic Areas:

All

Classification:

All

Include Generics:

Trade Name	Drug Name	Approved	Patent Expires	Indication
Kanuma	Sebelipase alfa	2015-12-08		Inborn errors lipid metabolism
Soliris	Eculizumab	2007-03-16		Paroxysmal hemoglobinuria , Myasthenia gravis , Atypical hemolytic uremic syndrome
Strensiq	Asfotase alfa	2015-10-23		Hypophosphatasia
Ultomiris	Ravulizumab	2018-12-21		Paroxysmal hemoglobinuria, Atypical hemolytic uremic syndrome

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

hypophosphatasia

Sebelipase alfa

mucopolysaccharidosis iv

,

glycogen storage disease type ii

,

lysosomal storage diseases

,

gaucher disease

,

,

cholesterol ester storage disease

,

,

failure to thrive

healthy volunteers/patients

,

,

end stage liver disease

,

kidney diseases

,

glomerulonephritis

,

membranoproliferative glomerulonephritis

,

,

,

chronic kidney failure

,

,

anti-neutrophil cytoplasmic antibody-associated vasculitis

,

,

,

multiple organ failure

,

diabetes mellitus

,

thrombocytopenia

,

complement activation

,

psychology rejection

,

renal insufficiency

,

wounds and injuries

,

reperfusion injury

,

chronic renal insufficiency

,

hemolytic anemia autoimmune

,

,

antiphospholipid syndrome

,

macular degeneration

,

geographic atrophy

,

,

dermatomyositis

,

autoimmune diseases

,

neuromyelitis optica

,

myasthenia gravis

,

kidney transplantation

,

muscle weakness

,

vascular diseases

,

thrombotic microangiopathies

,

guillain-barre syndrome

,

delayed graft function

,

escherichia coli infections

,

,

left ventricular dysfunction

,

ventricular dysfunction

,

shiga-toxigenic escherichia coli

,

,

,

malignant hypertension

,

hypertensive crisis

,

phenylketonurias

,

paroxysmal hemoglobinuria

,

,

,

,

hemolytic-uremic syndrome

,

atypical hemolytic uremic syndrome

,

,

,

coronavirus infections

,

respiratory distress syndrome

,

,

acute lung injury

,

hypophosphatasia

,

severe acute respiratory syndrome

,

viral pneumonia

,

,

newborn respiratory distress syndrome

,

,

protein-losing enteropathies

,

intestinal diseases

,

,

lymphangiectasis

,

intestinal lymphangiectasis

,

,

disease progression

,

intestinal obstruction

,

,

allergic fungal sinusitis

,

,

healthy volunteers/patients

,

hepatic insufficiency

,

renal insufficiency

,

glomerulonephritis

,

membranoproliferative glomerulonephritis

,

macular degeneration

,

geographic atrophy

,

,

paroxysmal hemoglobinuria

,

,

Mycophenolate sodium

kidney transplantation

,

delayed graft function

,

lupus nephritis

,

,

systemic lupus erythematosus

,

systemic scleroderma

,

,

juvenile arthritis

,

behcet syndrome

,

dermatomyositis

,

ankylosing spondylitis

,

rheumatoid arthritis

,

sjogren's syndrome

,

,

spondylarthritis

,

systemic vasculitis

Mycophenolic acid

kidney transplantation

,

delayed graft function

,

lupus nephritis

,

,

systemic lupus erythematosus

,

systemic scleroderma

,

,

juvenile arthritis

,

behcet syndrome

,

dermatomyositis

,

ankylosing spondylitis

,

rheumatoid arthritis

,

sjogren's syndrome

,

,

spondylarthritis

,

systemic vasculitis

,

rheumatoid arthritis

,

b-cell chronic lymphocytic leukemia

,

,

hodgkin disease

,

b-cell lymphoma

,

t-cell lymphoma cutaneous

,

bronchiolitis obliterans syndrome

,

,

t-cell lymphoma

,

follicular lymphoma

,

,

large-cell lymphoma anaplastic

,

t-cell lymphoma peripheral

,

non-hodgkin lymphoma

myocardial infarction

,

,

inferior wall myocardial infarction

,

coronary artery disease

,

cardiopulmonary bypass

,

coronary artery bypass

,

,

chronic hepatitis b

,

,

chronic hepatitis

,

Choline alfoscerate

healthy volunteers/patients

,

,

child development

,

,

,

male infertility

,

,

esophageal neoplasms

,

,

non-hodgkin lymphoma

,

,

hodgkin disease

,

large b-cell lymphoma diffuse

,

food diet and nutrition

,

lymphangioleiomyomatosis

,

,

pharmacokinetics

,

,

hepatocellular carcinoma

,

liver neoplasms

,

cardiovascular diseases

,

fetal alcohol spectrum disorders

,

breast neoplasms

,

cystic fibrosis

,

,

,

,

,

triple negative breast neoplasms

,

substance-related disorders

,

cognition disorders

,

neurodevelopmental disorders

,

,

marijuana abuse

,

heart valve diseases

,

,

myeloid leukemia acute

,

megakaryoblastic leukemia acute

,

monocytic leukemia acute

,

myelomonocytic leukemia acute

,

myeloid leukemia

,

erythroblastic leukemia acute

,

hypersensitivity

,

,

,

reperfusion injury

,

myocardial reperfusion injury

,

,

,

exocrine pancreatic insufficiency

,

follicular lymphoma

,

ulcerative colitis

,

knee osteoarthritis

,

,

,

autism spectrum disorder

,

pervasive child development disorders

,

prostatic neoplasms

,

,

hyperparathyroidism

,

hypertriglyceridemia

,

,

non-alcoholic fatty liver disease

,

hepatolenticular degeneration

,

,

,

prader-willi syndrome

,

primary hyperparathyroidism

,

premature birth

,

neoplasm metastasis

,

,

parathyroid neoplasms

,

coronary artery disease

,

ischemic stroke

,

,

coronary disease

,

metabolic syndrome

,

,

choline deficiency

,

diabetic neuropathies

,

,

multiple myeloma

,

plasma cell neoplasms

,

,

peripheral nervous system diseases

,

intestinal failure

,

severe acute malnutrition

,

castration-resistant prostatic neoplasms

,

parathyroid diseases

,

general anesthesia

,

hyperhomocysteinemia

,

liver cirrhosis

,

,

,

atherosclerotic plaque

,

,

,

brain hypoxia-ischemia

,

,

iron deficiencies

,

ornithine carbamoyltransferase deficiency disease

,

neuroprotection

,

,

,

,

cognitive dysfunction

,

alzheimer disease

,

,

,

,

,

neuromuscular blockade

,

,

traumatic brain injuries

,

,

,

cerebral infarction

,

,

,

diabetes mellitus

,

wounds and injuries

,

,

,

,

,

,

atherosclerosis

,

bipolar disorder

,

optic nerve diseases

,

,

myocardial infarction

,

cesarean section

,

rapid sequence induction and intubation

,

intratracheal intubation

,

chemical and drug induced liver injury

,

postoperative complications

,

muscle hypotonia

,

muscle relaxation

,

respiratory distress syndrome

,

autistic disorder

,

cocaine-related disorders

,

ischemic optic neuropathy

,

type 2 diabetes mellitus

,

alcohol drinking

,

microvascular angina

,

delayed emergence from anesthesia

,

asperger syndrome

,

,

,

psychotic disorders

,

,

,

,

alcoholic hepatitis

,

postoperative pain

,

neural conduction

,

carotid artery diseases

,

acute lung injury

,

newborn respiratory distress syndrome

,

respiratory aspiration

,

,

,

,

heart disease risk factors

,

brain neoplasms

,

depressive disorder

,

open-angle glaucoma

,

anxiety disorders

,

,

,

patient satisfaction

,

,

,

,

thyroid neoplasms

,

neuroendocrine carcinoma

,

thyroid diseases

,

,

major depressive disorder

,

,

,

,

,

prostatic hyperplasia

,

neuroendocrine tumors

,

,

,

,

,

body weight changes

,

,

adrenal insufficiency

,

non-small-cell lung carcinoma

,

infant nutrition disorders

,

alcoholic liver diseases

,

,

pulmonary atelectasis

,

papillary thyroid cancer

,

myocardial ischemia

,

coronary stenosis

,

,

bone marrow diseases

,

,

erdheim-chester disease

,

,

langerhans-cell histiocytosis

,

tourette syndrome

,

myasthenia gravis

,

muscle weakness

,

amphetamine-related disorders

,

,

liver transplantation

,

,

gestational diabetes

,

,

neurodegenerative diseases

,

,

,

carotid stenosis

,

irritable bowel syndrome

,

positron-emission tomography

,

total parenteral nutrition

,

endometrial neoplasms

,

uterine cervical neoplasms

,

lymphatic metastasis

,

muscle strength

,

,

,

uveal neoplasms

,

,

urologic neoplasms

,

amyotrophic lateral sclerosis

,

muscle spasticity

,

motor neuron disease

,

hereditary spastic paraplegia

,

,

,

postpartum depression

,

,

hypercholesterolemia

,

,

,

communicable diseases

,

,

smoking cessation

,

essential hypertension

,

,

,

neurotoxicity syndromes

,

peripheral nerve injuries

,

nerve degeneration

,

organophosphate poisoning

,

neuroinflammatory diseases

,

obstetrical anesthesia

,

emotional regulation

,

executive function

,

cold temperature

,

gastrointestinal diseases

,

digestive system diseases

,

,

,

exercise tolerance

,

therapeutic chemoembolization

,

underage drinking

,

,

head and neck neoplasms

,

gastrointestinal neoplasms

,

urogenital neoplasms

,

,

intestinal neoplasms

,

,

exfoliation syndrome

,

,

postoperative care

,

nutrition therapy

,

nutrition assessment

paroxysmal hemoglobinuria

,

,

,

b-cell chronic lymphocytic leukemia

,

t-cell lymphoma

,

hodgkin disease

,

follicular lymphoma

,

b-cell lymphoma

,

t-cell lymphoma cutaneous

,

bronchiolitis obliterans syndrome

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