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Company ReportsAlexion Pharmaceuticals

Alexion Pharmaceuticals(ALXN)

Alexion Pharmaceuticals is an American pharmaceutical company headquartered in Boston, Massachusetts that specializes in orphan drugs to treat rare diseases. It became an independent subsidiary of AstraZeneca in 2021.

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Financial

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Revenue by Drug

Marketed Drugs

Therapeutic Areas:

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Classification:

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Include Generics:

Trade Name	Drug Name	Approved	Patent Expires	Indication
Kanuma	Sebelipase alfa	2015-12-08		Inborn errors lipid metabolism
Soliris	Eculizumab	2007-03-16		Paroxysmal hemoglobinuria , Myasthenia gravis , Atypical hemolytic uremic syndrome
Strensiq	Asfotase alfa	2015-10-23		Hypophosphatasia
Ultomiris	Ravulizumab	2018-12-21		Paroxysmal hemoglobinuria, Atypical hemolytic uremic syndrome

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

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Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

hypophosphatasia

Sebelipase alfa

,

cholesterol ester storage disease

,

,

failure to thrive

glomerulonephritis

,

membranoproliferative glomerulonephritis

,

,

end stage liver disease

,

,

atypical hemolytic uremic syndrome

,

,

kidney transplantation

,

kidney diseases

,

,

anti-neutrophil cytoplasmic antibody-associated vasculitis

,

,

,

,

complement activation

,

psychology rejection

,

chronic renal insufficiency

,

hemolytic anemia autoimmune

,

,

macular degeneration

,

geographic atrophy

,

,

,

hemolytic-uremic syndrome

,

myasthenia gravis

,

neuromyelitis optica

,

muscle weakness

,

delayed graft function

,

guillain-barre syndrome

,

left ventricular dysfunction

,

ventricular dysfunction

,

escherichia coli infections

,

shiga-toxigenic escherichia coli

,

phenylketonurias

,

paroxysmal hemoglobinuria

,

,

,

respiratory distress syndrome

,

,

acute lung injury

,

hypophosphatasia

,

severe acute respiratory syndrome

,

viral pneumonia

,

,

newborn respiratory distress syndrome

,

,

disease progression

,

healthy volunteers/patients

,

hepatic insufficiency

,

renal insufficiency

,

glomerulonephritis

,

membranoproliferative glomerulonephritis

,

geographic atrophy

,

paroxysmal hemoglobinuria

,

,

,

healthy volunteers/patients

,

type 2 diabetes mellitus

,

,

,

,

non-small-cell lung carcinoma

,

,

respiratory syncytial virus infections

,

brain neoplasms

,

central nervous system neoplasms

,

,

glucose metabolism disorders

,

metabolic diseases

,

alzheimer disease

,

huntington disease

,

thyroid neoplasms

,

,

sickle cell anemia

,

atopic dermatitis

,

colorectal neoplasms

,

anxiety disorders

,

prostatic neoplasms

,

breast neoplasms

,

,

adenocarcinoma of lung

,

generalized anxiety disorder

,

reflex epilepsy

,

bipolar disorder

,

diabetes mellitus

,

,

status epilepticus

,

critical illness

,

,

psychomotor agitation

,

post-traumatic stress disorders

,

executive function

,

,

partial epilepsies

,

generalized epilepsy

,

complex partial epilepsy

,

,

insulin resistance

,

metabolic syndrome

,

,

major depressive disorder

,

depressive disorder

,

psychotic disorders

,

gastrointestinal endoscopy

,

hyperlipidemias

,

breast neoplasms

,

triple negative breast neoplasms

,

male breast neoplasms

,

squamous cell carcinoma

,

squamous cell carcinoma of head and neck

,

,

carcinoma in situ

,

squamous intraepithelial lesions

,

b-cell chronic lymphocytic leukemia

,

,

t-cell lymphoma

,

hodgkin disease

,

follicular lymphoma

,

b-cell lymphoma

,

t-cell lymphoma cutaneous

,

bronchiolitis obliterans syndrome

,

non-hodgkin lymphoma

coronary artery disease

,

cardiopulmonary bypass

,

coronary artery bypass

,

,

,

,

acquired immunodeficiency syndrome

,

,

,

,

communicable diseases

,

biliary liver cirrhosis

,

Choline alfoscerate

alzheimer disease

,

insulin resistance

,

nervous system neoplasms

,

,

glucose metabolism disorders

,

metabolic diseases

,

,

,

paraneoplastic syndromes

,

,

head and neck neoplasms

,

kidney neoplasms

,

colorectal neoplasms

,

colonic neoplasms

,

,

,

,

connective tissue neoplasms

,

,

pulmonary tuberculosis

,

,

,

langerhans-cell histiocytosis

,

uveal neoplasms

,

,

,

gastrointestinal stromal tumors

,

rhabdomyosarcoma

,

primitive neuroectodermal tumors peripheral

,

neuroendocrine carcinoma

,

,

pheochromocytoma

,

pancreatic neoplasms

,

diabetes mellitus

,

gastrointestinal neoplasms

,

type 1 diabetes mellitus

,

,

type 2 diabetes mellitus

,

prostatic neoplasms

,

small cell lung carcinoma

,

merkel cell carcinoma

,

endocrine system diseases

,

dumping syndrome

,

intestinal neoplasms

,

digestive system neoplasms

,

nasopharyngeal carcinoma

,

nasopharyngeal neoplasms

,

,

multiple myeloma

,

plasma cell neoplasms

,

,

cushing syndrome

,

hereditary hemorrhagic telangiectasia

,

endocrine gland neoplasms

,

thyroid neoplasms

,

germ cell and embryonal neoplasms

,

ovarian neoplasms

,

unknown primary neoplasms

,

somatostatinoma

,

von hippel-lindau disease

,

pituitary acth hypersecretion

,

premature cardiac complexes

,

carcinoma in situ

,

ductal carcinoma

,

intraductal carcinoma noninfiltrating

,

,

respiratory tract neoplasms

,

multiple endocrine neoplasia

,

islet cell carcinoma

,

acth-secreting pituitary adenoma

,

,

,

,

pleural effusion

,

lymphangioleiomyomatosis

,

lymphangiomyoma

,

,

chylous ascites

,

hematologic diseases

,

inborn genetic diseases

,

pathologic dilatation

,

,

small cell carcinoma

,

attention deficit disorder with hyperactivity

,

,

,

,

,

,

,

,

,

diffuse intrinsic pontine glioma

,

synovial sarcoma

,

desmoplastic small round cell tumor

,

triple negative breast neoplasms

,

carcinoid tumor

,

,

islet cell adenoma

,

breast neoplasms

,

neoplasm metastasis

,

malignant carcinoid syndrome

,

,

liver neoplasms

,

serotonin syndrome

,

autosomal dominant polycystic kidney

,

hepatocellular carcinoma

,

,

pituitary diseases

,

,

polycystic kidney diseases

,

,

kidney diseases

,

,

glomerular filtration rate

,

carcinoid heart disease

,

,

thymus neoplasms

,

,

pancreatic diseases

,

,

retinal diseases

,

diabetic retinopathy

,

,

gallbladder neoplasms

,

pancreaticoduodenectomy

,

,

vascular malformations

,

renal insufficiency

,

,

prader-willi syndrome

,

,

,

,

neuroendocrine tumors

,

,

,

,

,

,

portal hypertension

,

liver cirrhosis

,

esophageal and gastric varices

,

medulloblastoma

,

pituitary neoplasms

,

,

,

central nervous system neoplasms

,

stomach neoplasms

,

healthy volunteers/patients

,

,

gastrointestinal hemorrhage

,

pancreatic fistula

,

congenital hyperinsulinism

,

nesidioblastosis

,

hyperinsulinism

,

acute kidney injury

,

,

brain neoplasms

,

hemangioblastoma

,

olfactory esthesioneuroblastoma

,

intestinal obstruction

,

end stage liver disease

,

acute necrotizing pancreatitis

,

,

non-alcoholic fatty liver disease

,

,

esophageal neoplasms

,

,

,

,

,

duodenal neoplasms

,

,

glucose intolerance

,

papillary thyroid cancer

,

medullary carcinoma

,

venous thrombosis

,

surgical portasystemic shunt

,

postoperative pain

,

,

cardiovascular diseases

,

cardiomyopathies

,

circulating neoplastic cells

,

alcoholic fatty liver

,

renal circulation

,

renal plasma flow

,

pituitary dwarfism

,

,

,

nutrition disorders

,

feeding and eating disorders

,

,

metabolic syndrome

,

obstructive sleep apnea

,

sleep apnea syndromes

,

,

unconsciousness

,

,

transient ischemic attack

,

acute coronary syndrome

,

,

,

atherosclerosis

,

biliary tract neoplasms

,

,

,

,

feeding behavior

,

,

,

,

,

physiological stress

,

,

bone marrow diseases

,

non-hodgkin lymphoma

,

hodgkin disease

,

disease progression

,

sjogren's syndrome

,

gastrointestinal diseases

,

neoplasms by histologic type

,

neoplasms by site

,

nerve tissue neoplasms

,

digestive system diseases

,

intestinal diseases

,

neuroectodermal tumors

,

,

epstein-barr virus infections

,

,

heart valve diseases

,

hemostatic disorders

,

cardiac surgical procedures

,

coagulation protein disorders

,

neurodegenerative diseases

,

positron-emission tomography

,

liver transplantation

b-cell lymphoma

,

inflammatory breast neoplasms

,

immunoglobulin light-chain amyloidosis

,

myeloproliferative disorders

,

primary myelofibrosis

,

promyelocytic leukemia acute

,

myelomonocytic leukemia chronic

,

myelomonocytic leukemia acute

,

myelomonocytic leukemia juvenile

,

,

systemic scleroderma

,

diffuse scleroderma

,

,

large b-cell lymphoma diffuse

,

,

myeloid leukemia acute

,

precursor cell lymphoblastic leukemia-lymphoma

,

non-hodgkin lymphoma

,

lymphoid leukemia

,

,

myeloid leukemia

,

myelodysplastic syndromes

,

multiple myeloma

,

plasma cell neoplasms

,

bcr-abl positive chronic myelogenous leukemia

,

,

,

b-cell chronic lymphocytic leukemia

,

triple negative breast neoplasms

,

refractory anemia with excess of blasts

,

renal insufficiency

,

hematologic diseases

,

blood protein disorders

,

neoplasms by histologic type

,

paraproteinemias

,

hodgkin disease

,

diabetes mellitus

,

type 1 diabetes mellitus

,

prolymphocytic leukemia t-cell

,

prolymphocytic leukemia

,

,

burkitt lymphoma

,

graft vs host disease

,

bronchiolitis obliterans syndrome

,

aplastic anemia

,

breast neoplasms

,

brain stem neoplasms

,

glycogen storage disease type ii

,

glycogen storage disease type iii

,

ovarian neoplasms

,

hematologic neoplasms

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