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Company ReportsAlexion Pharmaceuticals

Alexion Pharmaceuticals(ALXN)

Alexion Pharmaceuticals is an American pharmaceutical company headquartered in Boston, Massachusetts that specializes in orphan drugs to treat rare diseases. It became an independent subsidiary of AstraZeneca in 2021.

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Clinical Trials

Financial

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Revenue by Drug

Marketed Drugs

Therapeutic Areas:

All

Classification:

All

Include Generics:

Trade Name	Drug Name	Approved	Patent Expires	Indication
Kanuma	Sebelipase alfa	2015-12-08		Inborn errors lipid metabolism
Soliris	Eculizumab	2007-03-16		Paroxysmal hemoglobinuria , Atypical hemolytic uremic syndrome
Strensiq	Asfotase alfa	2015-10-23		Hypophosphatasia
Ultomiris	Ravulizumab	2018-12-21		Paroxysmal hemoglobinuria, Atypical hemolytic uremic syndrome

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

hypophosphatasia

Sebelipase alfa

mucopolysaccharidosis iv

,

glycogen storage disease type ii

,

gaucher disease

,

,

cholesterol ester storage disease

,

,

failure to thrive

healthy volunteers/patients

,

,

end stage liver disease

,

kidney diseases

,

glomerulonephritis

,

membranoproliferative glomerulonephritis

,

,

,

chronic kidney failure

,

,

anti-neutrophil cytoplasmic antibody-associated vasculitis

,

,

,

multiple organ failure

,

diabetes mellitus

,

thrombocytopenia

,

complement activation

,

renal insufficiency

,

wounds and injuries

,

reperfusion injury

,

chronic renal insufficiency

,

hemolytic anemia autoimmune

,

,

antiphospholipid syndrome

,

macular degeneration

,

geographic atrophy

,

,

dermatomyositis

,

autoimmune diseases

,

neuromyelitis optica

,

kidney transplantation

,

myasthenia gravis

,

muscle weakness

,

vascular diseases

,

thrombotic microangiopathies

,

guillain-barre syndrome

,

delayed graft function

,

escherichia coli infections

,

,

left ventricular dysfunction

,

ventricular dysfunction

,

shiga-toxigenic escherichia coli

,

,

,

malignant hypertension

,

hypertensive crisis

,

phenylketonurias

,

paroxysmal hemoglobinuria

,

,

,

,

hemolytic-uremic syndrome

,

atypical hemolytic uremic syndrome

,

,

,

coronavirus infections

,

hypophosphatasia

,

respiratory distress syndrome

,

,

acute lung injury

,

viral pneumonia

,

,

newborn respiratory distress syndrome

,

,

protein-losing enteropathies

,

intestinal diseases

,

,

lymphangiectasis

,

intestinal lymphangiectasis

,

,

disease progression

,

intestinal obstruction

,

,

allergic fungal sinusitis

,

,

healthy volunteers/patients

,

,

hepatic insufficiency

,

renal insufficiency

,

glomerulonephritis

,

membranoproliferative glomerulonephritis

,

,

macular degeneration

,

geographic atrophy

,

,

paroxysmal hemoglobinuria

,

,

Mycophenolate sodium

autoimmune diseases

Calcium carbonate

,

,

,

,

,

,

colonic neoplasms

,

stomach neoplasms

,

fluoride poisoning

,

dental fluorosis

,

atrioventricular block

,

acquired immunodeficiency syndrome

,

,

head and neck neoplasms

,

esophageal neoplasms

,

,

ovarian epithelial carcinoma

,

,

,

postpartum hemorrhage

,

pharmacokinetics

,

healthy volunteers/patients

,

gastroesophageal reflux

,

,

,

ovarian neoplasms

,

autistic disorder

,

metabolic syndrome

,

,

spinal cord injuries

,

,

diabetic nephropathies

,

,

,

peritoneal neoplasms

,

autism spectrum disorder

,

pervasive child development disorders

,

gastrointestinal diseases

,

,

non-small-cell lung carcinoma

,

wounds and injuries

,

,

digestive system diseases

,

multiple myeloma

,

plasma cell neoplasms

,

,

myelodysplastic syndromes

,

,

chronic kidney disease-mineral and bone disorder

,

gaucher disease

,

,

,

musculoskeletal pain

,

osteogenesis imperfecta

,

postoperative cognitive complications

,

,

emergence delirium

,

,

infectious encephalitis

,

cognitive dysfunction

,

aflatoxin poisoning

,

radius fractures

,

wrist fractures

,

,

,

,

pathologic dilatation

,

vascular stiffness

,

,

metabolic brain diseases

,

hyperventilation

,

intellectual disability

,

,

intestinal diseases

,

breast neoplasms

,

,

,

chronic kidney failure

,

precursor cell lymphoblastic leukemia-lymphoma

,

,

lymphoid leukemia

,

,

colorectal neoplasms

,

neoplasm metastasis

,

,

,

,

,

communicable diseases

,

,

,

glucose intolerance

,

,

,

,

liver cirrhosis

,

endometrial neoplasms

,

adenomatous polyps

,

prostatic neoplasms

,

polycystic ovary syndrome

,

non-hodgkin lymphoma

,

,

respiratory tract infections

,

,

juvenile arthritis

,

,

iron-deficiency anemia

,

iron deficiencies

,

central nervous system neoplasms

,

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

philadelphia chromosome

,

essential thrombocythemia

,

,

ankylosing spondylitis

,

spondylarthritis

,

,

prediabetic state

,

,

,

bariatric surgery

,

hyperprolactinemia

,

,

dental pulp exposure

,

perinatal death

,

premature obstetric labor

,

premature birth

,

,

,

kidney diseases

,

vitamin d deficiency

,

chronic renal insufficiency

,

metabolic bone diseases

,

hyperphosphatemia

,

,

type 2 diabetes mellitus

,

postmenopausal osteoporosis

,

diabetes mellitus

,

,

,

hypersensitivity

,

bipolar disorder

,

hypoparathyroidism

,

hyperparathyroidism

,

cardiovascular diseases

,

renal insufficiency

,

rheumatoid arthritis

,

,

metabolic diseases

,

secondary hyperparathyroidism

,

pregnancy-induced hypertension

,

,

,

,

,

,

,

dentin sensitivity

,

,

,

,

,

depressive disorder

,

allergic rhinitis

,

,

non-alcoholic fatty liver disease

,

,

,

,

,

human influenza

,

,

interstitial lung diseases

,

,

,

,

pulmonary tuberculosis

,

,

tooth bleaching

,

,

physiologic calcification

,

pathologic bone demineralization

,

sjogren's syndrome

,

,

nutrition disorders

,

fetal nutrition disorders

,

neurodevelopmental disorders

,

,

,

benign paroxysmal positional vertigo

,

,

multiple sclerosis

,

,

critical illness

,

,

sleep deprivation

,

sensitivity and specificity

,

,

,

rotavirus infections

,

vascular calcification

,

postpartum depression

,

,

chronic hepatitis b

,

,

chronic hepatitis

,

heart valve prosthesis implantation

,

,

,

heart valve diseases

,

phosphorus metabolism disorders

,

insulin resistance

,

,

intracranial aneurysm

,

urinary tract infections

,

,

,

,

,

,

,

hyperaldosteronism

,

pulmonary arterial hypertension

,

,

sleep initiation and maintenance disorders

,

cardiac arrhythmias

,

,

nutritional and metabolic diseases

,

nutritional status

,

,

,

thyroid neoplasms

,

,

growth disorders

,

premenstrual syndrome

,

,

cerebral hemorrhage

,

hypertensive intracranial hemorrhage

,

thyroid diseases

,

acute kidney injury

,

parkinson disease

,

nephrolithiasis

,

,

atherosclerosis

,

spinal fractures

,

bone resorption

,

peptic esophagitis

,

,

,

urinary calculi

,

,

coronavirus infections

,

,

blood coagulation disorders

,

mucocutaneous lymph node syndrome

,

,

,

bronchopulmonary dysplasia

,

adrenal insufficiency

,

hemostatic disorders

,

coagulation protein disorders

,

attention deficit disorder with hyperactivity

,

,

primary hyperparathyroidism

,

accidental injuries

,

,

,

migraine disorders

,

,

bacterial infections

,

intraabdominal infections

,

healthcare-associated pneumonia

,

methicillin-resistant staphylococcus aureus

,

,

staphylococcal infections

,

,

general anesthesia

,

,

,

gram-negative bacterial infections

,

,

bacterial meningitis

,

,

central nervous system infections

,

neuromuscular blockade

,

,

cytomegalovirus retinitis

,

adenoviridae infections

,

port-wine stain

,

,

,

capillary hemangioma

,

,

,

,

treatment-resistant schizophrenia

,

potassium deficiency

,

brain neoplasms

,

,

,

,

cystic fibrosis

,

treatment adherence and compliance

,

muscle weakness

,

,

body mass index

,

,

major depressive disorder

,

,

,

,

,

,

,

,

energy metabolism

,

,

feeding behavior

,

geriatric psychiatry

,

,

ulcerative colitis

,

,

,

,

electromyography

,

,

tourette syndrome

,

stomatognathic diseases

,

dental pulp diseases

,

male breast neoplasms

,

,

unilateral breast neoplasms

,

,

,

,

,

chronic periodontitis

,

,

sports nutritional physiological phenomena

,

inflammatory bowel diseases

,

,

postoperative nausea and vomiting

,

,

,

atherosclerotic plaque

,

,

carotid intima-media thickness

,

,

,

,

oxidative stress

,

hyperlipidemias

,

hyperlipoproteinemias

,

alopecia areata

,

,

,

,

hyperthyroidism

,

,

atrial fibrillation

,

chronic disease

,

,

,

,

tooth discoloration

,

tension-type headache

,

osteoporotic fractures

,

,

,

macular degeneration

,

vision disorders

,

,

,

urine specimen collection

,

dietary supplements

,

cold temperature

,

peripheral nervous system diseases

,

diabetic neuropathies

,

cardiogenic shock

,

neoadjuvant therapy

,

sentinel lymph node biopsy

,

body weight changes

,

,

periapical diseases

,

,

,

,

hypercholesterolemia

,

,

,

uterine contraction

,

respiratory tract diseases

,

respiration disorders

,

attitudes health knowledge practice

,

sleep wake disorders

,

,

,

joint instability

,

diastolic heart failure

,

dental implants

pancreatic neoplasms

,

,

esophageal neoplasms

,

breast neoplasms

,

peripheral nervous system diseases

Antithrombin iii

healthy volunteers/patients

,

head and neck neoplasms

,

,

,

,

,

pharmacokinetics

,

,

,

thrombocytopenia

,

patent foramen ovale

,

paradoxical embolism

,

,

squamous cell carcinoma of head and neck

,

squamous cell carcinoma

,

female genital neoplasms

,

,

non-small-cell lung carcinoma

,

,

,

rheumatoid arthritis

,

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

bcr-abl positive chronic myelogenous leukemia

,

myeloid leukemia

,

,

wasting syndrome

,

,

,

,

kidney diseases

,

breast neoplasms

,

ischemic stroke

,

,

lymphoid leukemia

,

,

myeloid leukemia accelerated phase

,

myeloid leukemia chronic-phase

,

liver neoplasms

,

type 2 diabetes mellitus

,

diabetes mellitus

,

malignant mesothelioma

,

,

,

sickle cell anemia

,

brain neoplasms

,

neoplasm metastasis

,

,

bipolar disorder

,

transient ischemic attack

,

prostatic neoplasms

,

hypersensitivity

,

cerebral infarction

,

esophageal neoplasms

,

coronary artery bypass

,

atrial fibrillation

,

,

thromboembolism

,

,

venous thromboembolism

,

venous thrombosis

,

pulmonary embolism

,

,

,

chronic kidney failure

,

acute coronary syndrome

,

multiple myeloma

,

plasma cell neoplasms

,

right ventricular dysfunction

,

pulmonary infarction

,

,

ventricular dysfunction

,

pulmonary heart disease

,

antiphospholipid syndrome

,

renal insufficiency

,

,

small cell lung carcinoma

hypertriglyceridemia

healthy volunteers/patients

,

,

,

cardiomyopathies

,

polyneuropathies

,

familial amyloid neuropathies

,

amyloid neuropathies

,

non-hodgkin lymphoma

,

b-cell chronic lymphocytic leukemia

,

,

hodgkin disease

,

b-cell lymphoma

,

lymphoid leukemia

,

,

,

t-cell lymphoma

,

follicular lymphoma

,

large-cell lymphoma anaplastic

,

t-cell lymphoma peripheral

juvenile arthritis

,

myocardial infarction

,

,

inferior wall myocardial infarction

,

coronary artery disease

,

cardiopulmonary bypass

,

coronary artery bypass

insulin resistance

,

autoimmune diseases of the nervous system

,

,

nervous system malformations

,

kidney diseases

,

,

,

chronic hepatitis d

,

,

herpesviridae infections

,

,

patient acceptance of health care

,

multiple sclerosis

,

,

relapsing-remitting multiple sclerosis

,

,

drug-related side effects and adverse reactions

,

leukoencephalopathies

,

progressive multifocal leukoencephalopathy

,

hepatitis b virus

,

,

,

,

treatment adherence and compliance

,

,

hepatocellular carcinoma

,

liver neoplasms

,

,

,

,

,

,

chronic hepatitis b

,

acquired immunodeficiency syndrome

,

,

chronic hepatitis

,

,

immunologic deficiency syndromes

,

communicable diseases

,

,

,

medication adherence

,

,

substance-related disorders

,

,

patient compliance

,

healthy volunteers/patients

,

chronic renal insufficiency

,

renal insufficiency

,

,

persistent infection

,

cognitive dysfunction

,

chronic hepatitis c

,

,

,

,

kidney transplantation

,

non-hodgkin lymphoma

,

burkitt lymphoma

,

,

,

neurocognitive disorders

,

sleep wake disorders

,

,

,

,

anxiety disorders

,

metabolic diseases

,

opioid-related disorders

,

metabolic bone diseases

,

,

morphine dependence

,

hiv seronegativity

,

,

,

hiv seropositivity

,

,

liver cirrhosis

,

,

biliary liver cirrhosis

,

,

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