Salicylic acid
Salicylic acid is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target acid-sensing ion channel 3.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
| skin and connective tissue diseases | D017437 |
Trade Name
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| 111medco 2% salicylic acid cleansing bar | C200263 | 2023-12-12 |
| 24 alopecia reliefshampoo | unapproved drug other | 2020-08-08 |
| 28.5% salicylic acid | unapproved drug other | 2018-04-06 |
| 3 in 1 cleanser | OTC monograph final | 2020-09-16 |
| 3-1 acne treatment pads | C200263 | 2024-10-09 |
| 30 day acne treatment kit | OTC monograph final | 2023-08-23 |
| 45% urea cream 2% salicylic acid | C200263 | 2024-10-17 |
| aavrani dry scalp rescue serum | C200263 | 2023-10-25 |
| ac out spot stop serum | unapproved drug other | 2012-09-25 |
| acence tea tree tock blemish spot | OTC monograph final | 2016-01-22 |
Show 1403 more
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ATC Codes
D: Dermatologicals
— D01: Antifungals for dermatological use
— D01A: Antifungals for topical use
— D01AE: Other antifungals for topical use in atc
— D01AE12: Salicylic acid
— D02: Emollients and protectives
— D02A: Emollients and protectives
— D02AF: Salicylic acid emollient and protective preparations
M: Musculo-skeletal system drugs
— M02: Topical products for joint and muscular pain
— M02A: Topical products for joint and muscular pain
— M02AC: Preparations with salicylic acid derivatives, topical for joint and muscle pain
N: Nervous system drugs
— N02: Analgesics
— N02B: Other analgesics and antipyretics in atc
— N02BA: Salicylic acid and derivatives, analgesics and antipyretics
P: Antiparasitic products, insecticides and repellents
— P02: Anthelmintics
— P02D: Anticestodals
— P02DA: Salicylic acid derivative anticestodals
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01B: Antiinflammatory agents, ophthalmologic
— S01BC: Antiinflammatory agents, non-steroidal, ophthalmologic
— S01BC08: Salicylic acid
HCPCS
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Clinical
Clinical Trials
3629 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Stroke | D020521 | EFO_0000712 | I63.9 | 7 | 34 | 35 | 6 | 225 | 298 |
| Ischemic stroke | D000083242 | — | — | 8 | 25 | 29 | 4 | 182 | 239 |
| Ischemia | D007511 | EFO_0000556 | — | 17 | 21 | 16 | 4 | 171 | 221 |
| Retinal vein occlusion | D012170 | EFO_1001157 | H34.81 | 32 | 46 | 51 | 31 | 74 | 213 |
| Coronary artery disease | D003324 | — | I25.1 | 1 | 9 | 12 | 12 | 176 | 207 |
| Arterial occlusive diseases | D001157 | EFO_0009085 | — | 15 | 18 | 19 | 17 | 120 | 182 |
| Peripheral arterial disease | D058729 | EFO_0004265 | — | 11 | 19 | 12 | 14 | 124 | 172 |
| Macular edema | D008269 | — | — | 18 | 26 | 36 | 26 | 47 | 141 |
| Peripheral vascular diseases | D016491 | EFO_0003875 | I73.9 | 5 | 13 | 10 | 10 | 89 | 121 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | 1 | 3 | 5 | 9 | 102 | 118 |
Show 178 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pathologic constriction | D003251 | — | — | 1 | 1 | 1 | — | 41 | 44 |
| Depression | D003863 | — | F33.9 | 1 | 2 | 1 | — | 38 | 41 |
| Postpartum depression | D019052 | EFO_0007453 | F53.0 | — | 1 | 1 | — | 32 | 33 |
| Hernia | D006547 | HP_0100790 | K40-K46 | — | 6 | 1 | — | 25 | 31 |
| Diaphragmatic hernias congenital | D065630 | — | Q79.0 | — | 6 | 1 | — | 25 | 31 |
| Diaphragmatic hernia | D006548 | EFO_0008561 | K44 | — | 6 | 1 | — | 25 | 31 |
| Amblyopia | D000550 | HP_0000646 | H53.00 | 1 | — | 4 | — | 25 | 30 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | 2 | 1 | — | 26 | 28 |
| Carcinoma | D002277 | — | C80.0 | 8 | 9 | 1 | — | 12 | 27 |
| Chronic limb-threatening ischemia | D000089802 | — | — | 7 | 4 | 1 | — | 19 | 27 |
Show 133 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Malocclusion | D008310 | HP_0000689 | M26.4 | — | 1 | — | — | 24 | 25 |
| Bruxism | D002012 | — | F45.8 | 1 | 1 | — | — | 18 | 20 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | 1 | 1 | — | — | 18 | 20 |
| Joint diseases | D007592 | HP_0003040 | M12.9 | 1 | 1 | — | — | 17 | 18 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | 1 | 1 | — | — | 13 | 15 |
| Reperfusion injury | D015427 | — | — | 2 | 1 | — | — | 10 | 12 |
| Edentulous mouth | D009066 | — | — | — | 1 | — | — | 11 | 12 |
| Respiratory insufficiency | D012131 | HP_0002093 | J96.9 | — | 1 | — | — | 10 | 11 |
| Dental enamel hypoplasia | D003744 | EFO_1001304 | — | 2 | 2 | — | — | 8 | 10 |
| Artificial respiration | D012121 | — | — | — | 1 | — | — | 9 | 10 |
Show 146 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart arrest | D006323 | EFO_0009492 | I46 | 1 | — | — | — | 17 | 18 |
| Sleep apnea syndromes | D012891 | HP_0010535 | G47.3 | 1 | — | — | — | 14 | 15 |
| Obstructive sleep apnea | D020181 | EFO_0003918 | G47.33 | 1 | — | — | — | 11 | 12 |
| Aortic aneurysm | D001014 | EFO_0001666 | I71.9 | 2 | — | — | — | 9 | 11 |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | 1 | — | — | — | 8 | 9 |
| Respiratory tract diseases | D012140 | — | — | 1 | — | — | — | 7 | 8 |
| Respiration disorders | D012120 | — | J00-J99 | 1 | — | — | — | 7 | 8 |
| Recurrence | D012008 | — | — | 1 | — | — | — | 7 | 8 |
| Blood pressure | D001794 | EFO_0004325 | — | 2 | — | — | — | 5 | 7 |
| Brain injuries | D001930 | — | S06.9 | 1 | — | — | — | 5 | 6 |
Show 60 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Respiratory aspiration | D053120 | EFO_1001839 | — | — | — | — | — | 13 | 13 |
| Anterior cruciate ligament injuries | D000070598 | — | — | — | — | — | — | 13 | 13 |
| Blood flow restriction therapy | D000090003 | — | — | — | — | — | — | 13 | 13 |
| Bone fractures | D050723 | EFO_0003931 | T14.8 | — | — | — | — | 12 | 12 |
| Muscle weakness | D018908 | HP_0001324 | — | — | — | — | — | 11 | 11 |
| Patent foramen ovale | D054092 | HP_0001655 | Q21.12 | — | — | — | — | 11 | 11 |
| Intracranial arteriosclerosis | D002537 | EFO_1000860 | I67.2 | — | — | — | — | 10 | 10 |
| Emergencies | D004630 | — | — | — | — | — | — | 10 | 10 |
| Edentulous jaw | D007575 | — | — | — | — | — | — | 10 | 10 |
| Subarachnoid hemorrhage | D013345 | EFO_0000713 | I60 | — | — | — | — | 9 | 9 |
Show 716 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Salicylic acid |
| INN | — |
| Description | Salicylic acid is a monohydroxybenzoic acid that is benzoic acid with a hydroxy group at the ortho position. It is obtained from the bark of the white willow and wintergreen leaves. It has a role as an antiinfective agent, an antifungal agent, a keratolytic drug, an EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor, a plant metabolite, an algal metabolite and a plant hormone. It is a conjugate acid of a salicylate. |
| Classification | Small molecule |
| Drug class | anti-inflammatory agents (salicylic acid derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(O)c1ccccc1O |
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Salicylic acid
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Salicylic acid
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Sulfur
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Safety
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Adverse Events
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34,329 adverse events reported
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