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Drug ReportsPenicillin g benzathine
Penicillin g benzathine
Bicillin (penicillin g benzathine) is a small molecule pharmaceutical. Penicillin g benzathine was first approved as Permapen on 1982-01-01. It is used to treat actinomycosis, anthrax, bacterial infections, bacterial skin diseases, and botulism amongst others in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
musculoskeletal diseasesD009140
respiratory tract diseasesD012140
nervous system diseasesD009422
urogenital diseasesD000091642
cardiovascular diseasesD002318
skin and connective tissue diseasesD017437
animal diseasesD000820
signs and symptoms pathological conditionsD013568
chemically-induced disordersD064419
Trade Name
FDA
EMA
Bicillin l-a (discontinued: Bicillin, Bicillin l-a, Permapen)
Combinations
Bicillin c-r (discontinued: Bicillin c-r)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Penicillin g benzathine
Tradename
Company
Number
Date
Products
BICILLIN L-AKing PharmaceuticalsN-050141 RX1982-01-01
1 products, RLD, RS
Show 5 discontinued
Penicillin g benzathine
+
Penicillin g procaine
Tradename
Company
Number
Date
Products
BICILLIN C-RKing PharmaceuticalsN-050138 RX1982-01-01
1 products, RLD, RS
BICILLIN C-R 900/300King PharmaceuticalsN-050138 RX1982-01-01
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
bicillin c-r 900/300New Drug Application2024-06-03
bicillin crNew Drug Application2024-06-04
bicillin l-aNew Drug Application2024-07-12
extencillineunapproved drug for use in drug shortage2024-07-18
lentocilinunapproved drug for use in drug shortage2024-06-07
neolinnOTC monograph not final2021-06-02
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
J: Antiinfectives for systemic use
J01: Antibacterials for systemic use
J01C: Beta-lactam antibacterials, penicillins
J01CE: Beta-lactamase sensitive penicillins
J01CE08: Benzathine benzylpenicillin
HCPCS
Code
Description
J0558
Injection, penicillin g benzathine and penicillin g procaine, 100,000 units
J0561
Injection, penicillin g benzathine, 100,000 units
Clinical
No data
Drug
General
Drug common namePenicillin g benzathine
INN
Description
Benzathine benzylpenicillin, also known as benzathine penicillin G, is an antibiotic medication useful for the treatment of a number of bacterial infections. Specifically it is used to treat strep throat, diphtheria, syphilis, and yaws. It is also used to prevent rheumatic fever. It is given by injection into a muscle.
Classification
Small molecule
Drug classpenicillins
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)O.CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)O.O.O.O.O.c1ccc(CNCCNCc2ccccc2)cc1
Identifiers
PDB
CAS-ID1538-09-6
RxCUI
ChEMBL IDCHEMBL3989515
ChEBI ID
PubChem CID15232
DrugBankDB09323
UNII ID
Target
No data
Variants
No data
Financial
Revenue by drug
$
£
Bicillin Pfizer
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Estimated US medical usage
Penicillin g benzathine
Total medical expenditures per year (USD, in millions)
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Trends
No data
Safety
Black-box Warning
Black-box warning for: Bicillin c-r 900/300, Bicillin cr, Bicillin l-a
Adverse Events
0 adverse events reported
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