Penicillin g benzathine
Bicillin (penicillin g benzathine) is a small molecule pharmaceutical. Penicillin g benzathine was first approved as Permapen on 1982-01-01. It is used to treat actinomycosis, anthrax, bacterial infections, bacterial skin diseases, and botulism amongst others in the USA.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Bicillin l-a (discontinued: Bicillin, Bicillin l-a, Permapen)
CombinationsBicillin c-r (discontinued: Bicillin c-r)
Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Penicillin g benzathine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| BICILLIN L-A | King Pharmaceuticals | N-050141 RX | 1982-01-01 | 1 products, RLD, RS |
Show 5 discontinued
Penicillin g benzathine
+
Penicillin g procaine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| BICILLIN C-R | King Pharmaceuticals | N-050138 RX | 1982-01-01 | 1 products, RLD, RS |
| BICILLIN C-R 900/300 | King Pharmaceuticals | N-050138 RX | 1982-01-01 | 1 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| bicillin c-r 900/300 | New Drug Application | 2024-06-03 |
| bicillin cr | New Drug Application | 2024-06-04 |
| bicillin l-a | New Drug Application | 2024-07-12 |
| extencilline | unapproved drug for use in drug shortage | 2024-07-18 |
| lentocilin | unapproved drug for use in drug shortage | 2024-06-07 |
| neolinn | OTC monograph not final | 2021-06-02 |
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Clinical
Clinical Trials
837 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Tonsillitis | D014069 | — | — | — | — | 1 | 1 | — | 2 |
| Sinusitis | D012852 | EFO_0007486 | J32 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pneumonia | D011014 | EFO_0003106 | J18 | — | 1 | 1 | — | 2 | 4 |
| Bacterial pneumonia | D018410 | EFO_1001272 | J15.9 | — | 1 | 1 | — | — | 2 |
| Chronic bronchitis | D029481 | — | J42 | — | — | 1 | — | — | 1 |
| Bronchitis | D001991 | — | J40 | — | — | 1 | — | — | 1 |
| Acute disease | D000208 | — | — | — | — | 1 | — | — | 1 |
| Otitis media | D010033 | EFO_0004992 | H66.9 | — | — | 1 | — | — | 1 |
| Otitis | D010031 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Community-acquired pneumonia | D000098968 | — | — | — | — | — | — | 1 | 1 |
| Abscess | D000038 | EFO_0003030 | — | — | — | — | — | 1 | 1 |
| Peritonitis | D010538 | EFO_0008588 | K65 | — | — | — | — | 1 | 1 |
| Lung abscess | D008169 | EFO_1001362 | J85.2 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Penicillin g benzathine |
| INN | — |
| Description | Benzathine benzylpenicillin, also known as benzathine penicillin G, is an antibiotic medication useful for the treatment of a number of bacterial infections. Specifically it is used to treat strep throat, diphtheria, syphilis, and yaws. It is also used to prevent rheumatic fever. It is given by injection into a muscle.
|
| Classification | Small molecule |
| Drug class | penicillins |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)O.CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)O.O.O.O.O.c1ccc(CNCCNCc2ccccc2)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 1538-09-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3989515 |
| ChEBI ID | — |
| PubChem CID | 15232 |
| DrugBank | DB09323 |
| UNII ID | — |
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Bicillin – Pfizer
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Estimated US medical usage
Penicillin g benzathine
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Additional graphs summarizing 4,807 documents
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Safety
Black-box Warning
Black-box warning for: Bicillin c-r 900/300, Bicillin cr, Bicillin l-a
Adverse Events
Top Adverse Reactions
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1,184 adverse events reported
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