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Disease Reportsheart failure
MeSH D006333 - heart failure
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Clinical Trials
Competitive landscape
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D006331:Heart diseases
0 Companies
0 Drugs
Success rate
D006333: 
Heart failure
230 Companies
91 Drugs
$
Success rate
D004418:Paroxysmal dyspnea
1 Company
1 Drug
$
Success rate
D004489:Cardiac edema
0 Companies
0 Drugs
Success rate
D054143:Systolic heart failure
12 Companies
2 Drugs
$
Success rate
D054144:Diastolic heart failure
0 Companies
0 Drugs
Success rate
D059347:Cardio-renal syndrome
0 Companies
0 Drugs
Success rate
Events Timeline
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Commercial
Company Name
Drug Name
Trade Name
Patent Expires
Approval Date
Revenue
Period
Salix PharmaceuticalsChlorothiazide Diuril  1982-01-01   
TevaHydrochlorothiazide, Amiloride Amiloride Hydrochlorothiazide  1988-04-17   
Benazepril, Amlodipine besylate Amlodipine Besylate Benazepril  2007-05-18   
Valsartan, Amlodipine besylate Amlodipine Besylate Valsartan  2015-03-30   
Hydrochlorothiazide, Valsartan, Amlodipine besylate Amlodipine Besylate, Valsartan Hydrochlorothiazide  2012-09-25   
Olmesartan medoxomil, Amlodipine besylate Amlodipine Olmesartan Medoxomil  2016-10-26   
Atenolol Atenolol  1993-05-28   
Bisoprolol Bisoprolol  2001-06-26   
Hydrochlorothiazide, Bisoprolol Bisoprolol Hydrochlorothiazide  2000-09-27   
Bumetanide Bumetanide  1997-11-18   
Captopril Captopril  1996-02-13   
Hydrochlorothiazide, Captopril Captopril Hydrochlorothiazide  1998-06-18   
Carvedilol Carvedilol  2007-09-05   
Chlorthalidone Chlorthalidone  1982-01-01   
Hydralazine Dralzine  1982-01-01   
Enalapril Enalapril  2000-08-22   
Hydrochlorothiazide, Enalapril Enalapril Hydrochlorothiazide  2003-03-25   
Hydrochlorothiazide, Fosinopril Fosinopril Hydrochlorothiazide  2006-07-05   
Hydralazine Hydralazine  2000-02-23   
Hydrochlorothiazide, Hydralazine, Reserpine Hydralazine Hydrochloride, Hydrochlorothiazide Reserpine  1982-01-01   
Hydrochlorothiazide, Hydralazine Hydralazine W/ Hydrochlorothiazide  1984-04-10   
Hydrochlorothiazide Hydrochlorothiazide  2005-07-13   
Hydrochlorothiazide, Reserpine Hydrochlorothiazide W/ Reserpine  1982-01-01   
Hydrochlorothiazide, Hydralazine, Reserpine Hydroserpine (r)  1982-01-01   
Indapamide Indapamide  1997-04-04   
Irbesartan, Hydrochlorothiazide Irbesartan Hydrochlorothiazide  2012-03-30   
Irbesartan, Hydrochlorothiazide Irbesartan/Hydrochlorothiazide Teva  2009-11-26   
Isosorbide Isosorbide  2000-06-19   
Labetalol Labetalol  1998-09-30   
Lisinopril Lisinopril  2002-07-01   
Hydrochlorothiazide, Lisinopril Lisinopril Hydrochlorothiazide  2002-07-01   
Losartan potassium Losartan Potassium  2010-04-06   
Hydrochlorothiazide, Losartan potassium Losartan Potassium Hydrochlorothiazide  2010-04-06   
Hydrochlorothiazide, Methyldopa Methyldopa Hydrochlorothiazide  1988-03-08   
Metoprolol Metoprolol  1994-09-30   
Hydrochlorothiazide Microzide  1996-12-27   
Hydrochlorothiazide, Moexipril Moexipril Hydrochlorothiazide  2007-03-07   
Nadolol Nadolol  1994-08-31   
Olmesartan medoxomil Olmesartan Medoxomil  2017-04-24   
Hydrochlorothiazide, Olmesartan medoxomil Olmesartan Medoxomil Hydrochlorothiazide  2017-04-24   
Hydrochlorothiazide, Olmesartan medoxomil, Amlodipine besylate Olmesartan Medoxomil, Amlodipine Hydrochlorothiazide  2016-11-03   
Propranolol Propranolol  1987-10-07   
Propranolol, Hydrochlorothiazide Propranolol Hydrochlorothiazide  1988-12-01   
Ramipril Ramipril  2008-06-18   
Spironolactone Spironolactone  1982-01-01   
Hydrochlorothiazide, Spironolactone Spironolactone W/ Hydrochlorothiazide  1982-05-24   
Telmisartan Telmisartan Teva  2010-01-25   
Telmisartan Telmisartan Teva Pharma  2011-10-03   
Torsemide Torsemide  2002-05-14   
Trandolapril Trandolapril  2006-12-12   
Valsartan Valsartan  2016-01-04   
Bisoprolol Zebeta  1992-07-31   
Hydrochlorothiazide, Bisoprolol Ziac  1993-03-26   
Novast LaboratoriesChlorthalidone Chlorthalidone  2017-03-30   
Metoprolol Metoprolol  2018-02-06   
Nadolol Nadolol  2018-06-01   
Hydralazine, Isosorbide Isosorbide Hydralazine  2022-04-06   
PadagisAmiloride Midamor  1982-01-01   
Nitroglycerin Nitroglycerin  2013-09-20   
Taro PharmaceuticalCarvedilol Carvedilol  2007-09-05   
Enalapril Enalapril  2001-01-23   
Hydrochlorothiazide, Enalapril Enalapril Hydrochlorothiazide  2001-09-18   
Bumetanide Bumetanide  2023-07-24   
Glenmark PharmaceuticalsOlmesartan medoxomil, Amlodipine besylate Amlodipine Olmesartan Medoxomil  2017-07-05   
Hydrochlorothiazide, Bisoprolol Bisoprolol Hydrochlorothiazide  2022-01-26   
Carvedilol Carvedilol  2007-09-05   
Hydralazine Hydralazine  2009-05-29   
Hydrochlorothiazide, Moexipril Moexipril Hydrochlorothiazide  2010-03-17   
Nitroglycerin Nitroglycerin  2017-09-19   
Olmesartan medoxomil Olmesartan Medoxomil  2017-05-25   
Telmisartan Telmisartan  2014-07-07   
Telmisartan, Hydrochlorothiazide Telmisartan Hydrochlorothiazide  2019-03-04   
Verapamil, Trandolapril Trandolapril Verapamil  2010-05-05   
IngenusIvabradine Ivabradine  2021-12-30   
MylanAmlodipine, Valsartan Amlodipine / Valsartan Mylan  2016-03-22   
Benazepril, Amlodipine besylate Amlodipine Besylate Benazepril  2011-07-05   
Valsartan, Amlodipine besylate Amlodipine Besylate Valsartan  2015-03-30   
Atenolol Atenolol  1992-01-24   
Hydrochlorothiazide, Benazepril Benazepril Hydrochlorothiazide  2004-02-11   
Hydrochlorothiazide, Bisoprolol Bisoprolol Hydrochlorothiazide  2000-09-25   
Candesartan cilexetil Candesartan Cilexetil  2013-05-03   
Hydrochlorothiazide, Candesartan cilexetil Candesartan Cilexetil Hydrochlorothiazide  2012-12-04   
Carvedilol Carvedilol  2007-09-05   
Chlorothiazide Chlorothiazide  1982-01-01   
Chlorothiazide, Reserpine Chlorothiazide-reserpine  1982-05-06   
Chlorthalidone Chlorthalidone  1982-01-01   
Torsemide Demadex  1993-08-23   
Enalapril Enalapril  2000-08-22   
Eprosartan Eprosartan  2011-11-16   
Esmolol Esmolol  2005-05-02   
Hydrochlorothiazide, Fosinopril Fosinopril Hydrochlorothiazide  2006-08-14   
Furosemide Furosemide  1986-10-29   
Hydralazine Hydralazine  2010-12-08   
Hydrochlorothiazide, Hydralazine, Reserpine Hydralazine Hydrochloride-hydrochlorothiazide-reserpine  1982-01-01   
Hydrochlorothiazide Hydrochlorothiazide  2007-01-23   
Irbesartan, Hydrochlorothiazide Irbesartan Hydrochlorothiazide  2012-09-27   
Hydrochlorothiazide, Lisinopril Lisinopril Hydrochlorothiazide  2002-07-01   
Losartan potassium Losartan Potassium  2010-10-06   
Hydrochlorothiazide, Losartan potassium Losartan Potassium Hydrochlorothiazide  2010-04-06   
Metolazone Metolazone  2003-12-23   
Metoprolol tartrate, Metoprolol Metoprolol  1993-12-21   
Hydrochlorothiazide, Metoprolol Metoprolol Hydrochlorothiazide  2004-08-20   
Milrinone Milrinone  2003-06-16   
Nitroglycerin Nitroglycerin  1996-08-30   
Propranolol Propranolol  1985-11-19   
Hydrochlorothiazide, Quinapril Quinapril Hydrochlorothiazide  2005-03-28   
Spironolactone Spironolactone  2001-08-20   
Hydrochlorothiazide, Spironolactone Spironolactone Hydrochlorothiazide  1982-01-01   
Telmisartan Telmisartan  2014-07-07   
Telmisartan, Amlodipine besylate Telmisartan Amlodipine  2014-08-26   
Trandolapril Trandolapril  2008-04-28   
Hydrochlorothiazide, Triamterene Triamterene Hydrochlorothiazide  1996-06-07   
Valsartan Valsartan  2015-01-05   
Hydrochlorothiazide, Valsartan Valsartan Hydrochlorothiazide  2012-09-21   
Rising PharmaceuticalsBenazepril, Amlodipine besylate Amlodipine Besylate Benazepril  2010-05-21   
Propranolol hydrochloride Propranolol  2007-02-15   
Carvedilol Carvedilol  2007-09-05   
Hydrochlorothiazide, Amiloride Amiloride Hydrochlorothiazide  1991-10-31   
Bumetanide Bumetanide  2019-12-12   
Hydrochlorothiazide, Captopril Captopril Hydrochlorothiazide  1997-12-29   
Digoxin Digoxin  1999-12-23   
Hydrochlorothiazide, Enalapril Enalapril Hydrochlorothiazide  2001-09-18   
Indapamide Indapamide  1996-03-27   
Hydrochlorothiazide, Methyldopa Methyldopa Hydrochlorothiazide  1986-01-23   
Nadolol Nadolol  1993-10-31   
Olmesartan medoxomil Olmesartan Medoxomil  2016-10-26   
Propranolol, Hydrochlorothiazide Propranolol Hydrochlorothiazide  1987-03-04   
Hydralazine Hydralazine  2018-07-09   
Lisinopril Lisinopril  2002-07-01   
Chlorothiazide Diuril  1982-01-01   
Labetalol Labetalol  1999-11-29   
NATCO PharmaNitroglycerin Nitroglycerin  2019-04-30   
Hydrochlorothiazide, Olmesartan medoxomil Olmesartan Medoxomil Hydrochlorothiazide  2016-10-26   
Clonidine, Chlorthalidone Clorpres  1987-02-09   
Bendroflumethiazide, Nadolol Nadolol Bendroflumethiazide  2008-02-15   
Ramipril Ramipril  2011-06-30   
Telmisartan, Hydrochlorothiazide Telmisartan Hydrochlorothiazide  2014-02-25   
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3
4
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6
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Clinical Trials
Historical Success Rate
Phase 1
70%
66/94
Phase 2
62%
86/139
Phase 3
76%
142/188
Approved: 60Overall Success rate: 33%
All Clinical Trials
Therapeutic Areas:
All
Classification:
All
Approval:
All
Status:
All
Phases:
All
Company name
Phase 1
Phase 2
Phase 3
Phase 4
Drug Name
Teva
Amlodipine besylate,
Benazepril,
Carvedilol,
Hydrochlorothiazide,
Losartan potassium,
Moexipril,
Ramipril,
Trandolapril
Mylan
Propranolol,
Amlodipine,
Hydrochlorothiazide,
Timolol,
Benazepril,
Atenolol,
Metoprolol,
Losartan potassium,
Quinapril,
Carvedilol,
Chlorothiazide,
Metolazone,
Amlodipine besylate,
Propranolol hydrochloride,
Metoprolol tartrate,
Aspartame,
Selara
GSK
Hydrochlorothiazide,
Digoxin,
Labetalol,
Hypromellose,
Benzocaine,
Docusate,
Edrecolomab,
Icosapent,
Doconexent,
Aldosterone,
Aspartame,
Bevifimod,
Nepidermin,
Riboprine,
Gw510516x,
GSK-2798745
Roche
Benzimidazole,
Resiniferatoxin,
Canrenoate potassium,
Aspartame,
Levoglucose,
Spirolactone,
Endocrine,
Magnesium sulfate anhydrous,
Sominex
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6
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