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Company ReportsSpark Therapeutics

Spark Therapeutics(ONCE)

Spark Therapeutics, Inc. is a developer of gene therapy treatments, which treat debilitating genetic diseases. It is a subsidiary of Hoffmann-La Roche.

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Therapeutic Areas:

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Include Generics:

Trade Name	Drug Name	Approved	Patent Expires	Indication
Luxturna	Voretigene neparvovec	2017-12-19		Retinitis pigmentosa , Leber congenital amaurosis

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

Voretigene neparvovec

retinal dystrophies

hematologic neoplasms

,

biphenotypic leukemia acute

,

b-cell leukemia

,

precursor cell lymphoblastic leukemia-lymphoma

,

stomach neoplasms

,

myelodysplastic syndromes

,

,

muscle spasticity

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

,

,

b-cell lymphoma

,

ovarian neoplasms

,

,

b-cell lymphoma marginal zone

,

fallopian tube neoplasms

,

burkitt lymphoma

,

multiple myeloma

,

prostatic neoplasms

,

pancreatic neoplasms

,

triple negative breast neoplasms

,

esophageal neoplasms

,

squamous cell carcinoma of head and neck

,

reactive arthritis

,

waldenstrom macroglobulinemia

,

lymphoproliferative disorders

,

lymphatic diseases

,

intestinal neoplasms

,

colonic neoplasms

,

rectal neoplasms

,

,

,

,

neuroendocrine carcinoma

,

papillary thyroid cancer

,

,

primary myelofibrosis

,

,

hairy cell leukemia

,

abdominal hernia

,

,

breast neoplasms

,

urinary bladder neoplasms

,

uterine neoplasms

,

knee osteoarthritis

,

residual neoplasm

,

,

interstitial cystitis

,

neoadjuvant therapy

,

ovarian epithelial carcinoma

,

mantle-cell lymphoma

,

female genital neoplasms

,

peritoneal neoplasms

,

,

non-hodgkin lymphoma

,

,

non-small-cell lung carcinoma

,

b-cell chronic lymphocytic leukemia

,

,

myeloid leukemia acute

,

colorectal neoplasms

,

large b-cell lymphoma diffuse

,

follicular lymphoma

,

,

,

musculoskeletal diseases

,

ankylosing spondylitis

,

small cell lung carcinoma

,

multiple sclerosis

,

relapsing-remitting multiple sclerosis

,

inflammatory bowel diseases

,

macular degeneration

,

,

juvenile arthritis

,

neoplasm metastasis

,

,

papulosquamous skin diseases

,

wet macular degeneration

,

,

lymphoid leukemia

,

,

communicable diseases

,

bacterial infections

,

methicillin-resistant staphylococcus aureus

,

staphylococcal skin infections

,

infectious skin diseases

,

bacterial skin diseases

,

,

disease progression

,

,

parkinson disease

,

bronchopulmonary dysplasia

,

respiratory syncytial viruses

,

,

,

pyoderma gangrenosum

,

spondylarthropathies

,

spondylarthritis

,

spinal diseases

,

,

intermediate uveitis

,

posterior uveitis

,

precocious puberty

,

migraine disorders

,

retinal diseases

,

retinal degeneration

,

,

choroidal neovascularization

,

hepatocellular carcinoma

,

liver neoplasms

,

thyroid diseases

,

,

rheumatoid arthritis

,

,

,

ulcerative colitis

,

psoriatic arthritis

,

,

chronic hepatitis c

,

hidradenitis suppurativa

,

axial spondyloarthritis

,

cardiovascular diseases

,

connective tissue diseases

,

,

,

,

drug monitoring

,

coronary artery disease

,

myocardial ischemia

,

,

atherosclerosis

Globulin, immune

neurologic manifestations

,

gastrointestinal neoplasms

,

thoracic neoplasms

,

,

small cell carcinoma

,

,

digestive system neoplasms

,

,

respiratory tract neoplasms

,

bronchogenic carcinoma

,

endocrine gland neoplasms

,

breast diseases

,

bronchial neoplasms

,

breast neoplasms

,

neoplasm metastasis

,

pancreatic neoplasms

,

,

,

brain neoplasms

,

esophageal neoplasms

,

liver neoplasms

,

,

follicular lymphoma

,

squamous cell neoplasms

,

non-hodgkin lymphoma

,

b-cell lymphoma

,

,

hepatocellular carcinoma

,

t-cell lymphoma

,

t-cell lymphoma peripheral

,

cholangiocarcinoma

,

esophageal squamous cell carcinoma

,

biliary tract neoplasms

,

,

kidney neoplasms

,

prostatic neoplasms

,

mantle-cell lymphoma

,

pancreatic ductal carcinoma

,

urethral neoplasms

,

ureteral neoplasms

,

neoplasms by histologic type

,

b-cell lymphoma marginal zone

,

castration-resistant prostatic neoplasms

,

nasopharyngeal neoplasms

,

multiple myeloma

,

pelvic neoplasms

,

,

mouth neoplasms

,

oropharyngeal neoplasms

,

glandular and epithelial neoplasms

,

hypopharyngeal neoplasms

,

serous cystadenocarcinoma

,

endometrioid carcinoma

,

t-cell lymphoma cutaneous

,

,

waldenstrom macroglobulinemia

,

kidney diseases

,

,

invasive hydatidiform mole

,

laryngeal neoplasms

,

neuroendocrine tumors

,

myeloid leukemia acute

,

precursor cell lymphoblastic leukemia-lymphoma

,

central nervous system diseases

,

histiocytic sarcoma

,

follicular dendritic cell sarcoma

,

interdigitating dendritic cell sarcoma

,

gallbladder neoplasms

,

chronic kidney failure

,

uterine neoplasms

,

,

mullerian mixed tumor

,

,

nervous system diseases

,

nerve tissue neoplasms

,

neuroepithelial neoplasms

,

neuroectodermal tumors

,

bile duct neoplasms

,

,

neoplasms by site

,

acinar cell carcinoma

,

,

sezary syndrome

,

mycosis fungoides

,

,

hematologic diseases

,

bone marrow diseases

,

non-muscle invasive bladder neoplasms

,

unknown primary neoplasms

,

immunoblastic lymphadenopathy

,

enteropathy-associated t-cell lymphoma

,

merkel cell carcinoma

,

,

x-linked bulbo-spinal atrophy

,

nasopharyngeal carcinoma

,

microsatellite repeats

,

,

,

plasma cell neoplasms

,

epstein-barr virus infections

,

local neoplasm recurrence

,

hypersensitivity

,

adenoviridae infections

,

gastrointestinal stromal tumors

,

male breast neoplasms

,

adenosquamous carcinoma

,

uveal neoplasms

,

non-small-cell lung carcinoma

,

,

colorectal neoplasms

,

squamous cell carcinoma of head and neck

,

,

,

,

head and neck neoplasms

,

squamous cell carcinoma

,

ovarian neoplasms

,

,

triple negative breast neoplasms

,

renal cell carcinoma

,

large b-cell lymphoma diffuse

,

stomach neoplasms

,

uterine cervical neoplasms

,

urinary bladder neoplasms

,

hodgkin disease

,

fallopian tube neoplasms

,

,

endometrial neoplasms

,

b-cell chronic lymphocytic leukemia

,

transitional cell carcinoma

,

small cell lung carcinoma

,

ovarian epithelial carcinoma

,

urologic neoplasms

,

rectal neoplasms

,

psoriatic arthritis

,

colonic neoplasms

,

,

malignant mesothelioma

,

clostridium infections

,

,

lymphoid leukemia

,

juvenile arthritis

,

,

,

cutaneous malignant melanoma

,

inflammatory bowel diseases

,

peritoneal neoplasms

,

axial spondyloarthritis

,

chronic hepatitis c

,

respiratory syncytial virus infections

,

,

,

,

dermatomyositis

,

inclusion body myositis

,

,

polymyalgia rheumatica

,

spondylarthropathies

,

spondylarthritis

,

,

rheumatoid arthritis

,

,

,

ankylosing spondylitis

,

,

ulcerative colitis

,

communicable diseases

,

,

,

,

papillomavirus infections

,

,

acquired immunodeficiency syndrome

,

immunologic deficiency syndromes

,

,

pneumococcal infections

,

prostatic intraepithelial neoplasia

,

carcinoma in situ

,

uterine cervical dysplasia

,

papillomavirus vaccines

,

,

,

coronavirus infections

,

human influenza

,

,

anti-neutrophil cytoplasmic antibody-associated vasculitis

,

intestinal neoplasms

,

human papillomavirus recombinant vaccine quadrivalent types 6 11 16 18

,

agammaglobulinemia

,

common variable immunodeficiency

,

papillomaviridae

,

chronic renal insufficiency

,

flavivirus infections

,

,

,

,

,

prediabetic state

,

hypercholesterolemia

,

cerebrovascular disorders

,

diabetes mellitus

,

coronary artery disease

,

peripheral arterial disease

,

,

healthy volunteers/patients

von willebrand diseases

,

thrombotic thrombocytopenic purpura

,

,

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