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La Jolla Pharmaceutical Company
La Jolla Pharmaceutical Company
(LJPC)
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Drug Name
Phase 1
Phase 2
Phase 3
Phase 4
Indication
Angiotensin ii
healthy volunteers/patients
,
hypertrophic cardiomyopathy
,
cardiomyopathies
,
headache
,
cluster headache
,
diabetic retinopathy
,
breast neoplasms
,
hyperkalemia
,
migraine disorders
,
migraine without aura
,
migraine with aura
,
aortic valve stenosis
,
pathologic constriction
,
cardiotoxicity
,
retinal diseases
,
proteinuria
,
atrial fibrillation
,
stroke
,
chronic renal insufficiency
,
renal insufficiency
,
hypertension
,
heart failure
,
type 2 diabetes mellitus
,
diabetes mellitus
,
type 1 diabetes mellitus
,
hypertrophy
,
obesity
,
kidney diseases
,
left ventricular dysfunction
,
ventricular dysfunction
,
left ventricular hypertrophy
,
glucose intolerance
,
cohort studies
,
essential hypertension
,
diabetic nephropathies
Ademetionine
heart failure
Calcium dobesilate
neoplasms
,
b-cell lymphoma
,
immunoglobulin light-chain amyloidosis
,
amyloidosis
,
non-hodgkin lymphoma
,
hematologic neoplasms
,
recurrence
,
smoldering multiple myeloma
,
waldenstrom macroglobulinemia
,
lymphoma
,
leukemia
,
precursor cell lymphoblastic leukemia-lymphoma
,
lymphoid leukemia
,
multiple myeloma
,
plasma cell neoplasms
Serine
heart failure
,
ischemic stroke
,
stroke
,
patent foramen ovale
,
atrial fibrillation
Sodium chloride
substance withdrawal syndrome
,
syndrome
,
alagille syndrome
,
liver diseases
,
cholestasis
Sodium lactate
large b-cell lymphoma diffuse
,
lymphoma
,
b-cell lymphoma
,
non-hodgkin lymphoma
,
hodgkin disease
Aldosterone
heart failure
,
atrial fibrillation
Aspartame
healthy volunteers/patients
,
therapeutic equivalency
Bevifimod
renal cell carcinoma
,
human influenza
,
nutritional status
,
pneumococcal infections
,
pneumococcal pneumonia
,
leishmaniasis
,
psoriasis
,
systemic lupus erythematosus
,
cutaneous lupus erythematosus
,
inflammatory bowel diseases
,
virus diseases
,
urticaria
,
tendon injuries
,
dermatitis
,
haemophilus influenzae
,
streptococcus pneumoniae
,
cancer pain
,
oncogenes
,
crohn disease
,
energy metabolism
,
endometrial neoplasms
,
carcinosarcoma
,
mullerian mixed tumor
,
fibrosis
,
idiopathic pulmonary fibrosis
,
pulmonary fibrosis
,
lung neoplasms
,
non-small-cell lung carcinoma
,
malaria
,
neoplasm metastasis
,
carcinoma
,
falciparum malaria
,
ovarian neoplasms
,
brain neoplasms
,
healthy volunteers/patients
,
prostatic neoplasms
,
asthma
,
recurrence
,
colorectal neoplasms
,
squamous cell carcinoma
,
multiple myeloma
,
plasma cell neoplasms
,
ovarian epithelial carcinoma
,
cutaneous malignant melanoma
,
skin neoplasms
,
type 1 diabetes mellitus
,
triple negative breast neoplasms
,
squamous cell carcinoma of head and neck
,
sickle cell anemia
,
myeloid leukemia acute
,
myeloid leukemia
,
leukemia
,
hepatitis b
,
chronic hepatitis b
,
hepatitis
,
primary myelofibrosis
,
hepatocellular carcinoma
,
liver neoplasms
,
fallopian tube neoplasms
,
pancreatic neoplasms
,
neuralgia
,
hematologic neoplasms
,
ductal carcinoma
,
circulating neoplastic cells
,
uterine neoplasms
,
uterine cervical neoplasms
,
glioma
,
streptococcus agalactiae
,
lymphoma
,
follicular lymphoma
,
neisseria meningitidis
,
haemophilus influenzae type b
,
invasive hydatidiform mole
,
biliary tract neoplasms
,
uveal neoplasms
,
respiratory tract diseases
,
respiration disorders
,
proteinuria
,
focal segmental glomerulosclerosis
,
cytomegalovirus infections
,
chronic hepatitis
,
kidney diseases
,
membranous glomerulonephritis
,
nephrotic syndrome
,
nephrosis
,
glioblastoma
,
endometrioid carcinoma
,
breast diseases
,
squamous cell neoplasms
,
neurofibromatosis 2
,
acoustic neuroma
,
neurofibromatosis 1
,
neurofibromatoses
,
neurofibroma
,
neurilemmoma
,
drug therapy
,
tuberculosis
,
pulmonary tuberculosis
,
adenocarcinoma of lung
,
disease progression
,
peritoneal neoplasms
,
inflammation
,
beta-thalassemia
,
thalassemia
,
sickle cell trait
,
essential thrombocythemia
,
polycythemia vera
,
thrombocytosis
,
polycythemia
,
ulcer
,
buruli ulcer
,
breast neoplasms
,
melanoma
,
rheumatoid arthritis
,
arthritis
,
head and neck neoplasms
,
inflammatory breast neoplasms
,
adenocarcinoma
,
respiratory syncytial virus infections
,
covid-19
,
bacterial infections
,
cellulitis
,
streptococcal infections
,
hepatitis a
,
stomach neoplasms
,
gastrointestinal neoplasms
,
digestive system neoplasms
,
infectious skin diseases
,
bacterial skin diseases
,
ductal carcinoma breast
,
renal insufficiency
,
mumps
,
measles
,
rubella
,
urinary bladder neoplasms
,
acute coronary syndrome
,
syndrome
,
rotavirus infections
,
otitis media
,
mucinous adenocarcinoma
,
meningitis
,
meningococcal meningitis
,
impetigo
,
respiratory syncytial viruses
,
herpes zoster
,
neoplasms
,
type 2 diabetes mellitus
,
diabetes mellitus
,
hiv infections
,
infections
,
acquired immunodeficiency syndrome
,
acne vulgaris
,
chronic obstructive pulmonary disease
,
communicable diseases
,
lung diseases
,
obstructive lung diseases
,
pneumonia
,
dental focal infection
,
focal infection
,
nausea
,
hiv
,
immunologic deficiency syndromes
,
ventilator-associated pneumonia
,
growth and development
,
immunologic tests
,
cognition
,
alzheimer disease
,
wasting syndrome
,
cachexia
,
dyslipidemias
,
insulin resistance
,
abdominal obesity
,
lipid metabolism
,
latent autoimmune diabetes in adults
,
community-acquired infections
,
abscess
,
folliculitis
,
staphylococcal infections
,
resistance training
,
exercise
,
depression
,
major depressive disorder
,
depressive disorder
,
thyroid neoplasms
,
papillary thyroid cancer
,
thyroid diseases
,
clostridioides difficile
Hepcidin
anemia
,
iron-deficiency anemia
,
iron deficiencies
,
neoplasm metastasis
,
inflammatory bowel diseases
,
deficiency diseases
Microcrystalline cellulose
large b-cell lymphoma diffuse
,
lymphoma
,
b-cell lymphoma
,
non-hodgkin lymphoma
,
hodgkin disease
Vp16
large granular lymphocytic leukemia
,
neuroepithelial neoplasms
,
pharyngeal neoplasms
,
peritoneal neoplasms
,
melanoma
,
urethral neoplasms
,
pancreatic ductal carcinoma
,
esophageal squamous cell carcinoma
,
deltaretrovirus infections
,
htlv-i infections
,
stem cell transplantation
,
inflammatory breast neoplasms
,
essential thrombocythemia
,
polycythemia vera
,
leukemia myeloid chronic atypical bcr-abl negative
,
myeloid leukemia accelerated phase
,
neutrophilic leukemia chronic
,
thrombocytosis
,
polycythemia
,
female genital neoplasms
,
skin neoplasms
,
mouth neoplasms
,
malignant mesothelioma
,
mesothelioma
,
endocrine gland neoplasms
,
thyroid diseases
,
male genital neoplasms
,
cutaneous malignant melanoma
,
glandular and epithelial neoplasms
,
b-cell chronic lymphocytic leukemia
,
plasmacytoma
,
hematologic neoplasms
,
b-cell lymphoma marginal zone
,
aids-related lymphoma
,
graft vs host disease
,
neuroendocrine tumors
,
adult t-cell leukemia-lymphoma
,
lymphomatoid granulomatosis
,
t-cell lymphoma cutaneous
,
mycoses
,
mycosis fungoides
,
lymphoproliferative disorders
,
sezary syndrome
,
hairy cell leukemia
,
intraocular lymphoma
,
fallopian tube neoplasms
,
primary effusion lymphoma
,
intestinal neoplasms
,
radiation effects
,
castleman disease
,
triple negative breast neoplasms
,
gliosarcoma
,
pancreatic neoplasms
,
hematologic diseases
,
astrocytoma
,
urologic neoplasms
,
uterine cervical neoplasms
,
hiv
,
plasma cell leukemia
,
precancerous conditions
,
intestinal diseases
,
prolymphocytic leukemia t-cell
,
prolymphocytic leukemia
,
castration-resistant prostatic neoplasms
,
thrombocytopenia
,
diffuse intrinsic pontine glioma
,
radiotherapy
,
merkel cell carcinoma
,
transitional cell carcinoma
,
immunoglobulin light-chain amyloidosis
,
amyloidosis
,
desmoplastic small round cell tumor
,
adenosquamous carcinoma
,
neurofibrosarcoma
,
nerve sheath neoplasms
,
thyroid neoplasms
,
prolymphocytic leukemia b-cell
,
oligodendroglioma
,
paranasal sinus neoplasms
,
pinealoma
,
clear cell sarcoma
,
pneumocephalus
,
primary myelofibrosis
,
myeloid leukemia chronic-phase
,
blast crisis
,
residual neoplasm
,
head and neck neoplasms
,
hypoxia
,
heavy ion radiotherapy
,
immunotherapy
,
neoadjuvant therapy
,
human herpesvirus 8
,
meningeal carcinomatosis
,
islet cell carcinoma
,
large cell carcinoma
,
brain stem neoplasms
,
colorectal neoplasms
,
clonal hematopoiesis
,
cytopenia
,
aneuploidy
,
vasculitis
,
autoimmune diseases
,
nervous system diseases
,
autoimmune diseases of the nervous system
,
autologous transplantation
,
neuromyelitis optica
,
myasthenia gravis
,
ocular motility disorders
,
polyneuropathies
,
muscle weakness
,
myoclonus
,
stiff-person syndrome
,
central nervous system vasculitis
,
spinocerebellar degenerations
,
chronic inflammatory demyelinating polyradiculoneuropathy
,
lambert-eaton myasthenic syndrome
,
opsoclonus-myoclonus syndrome
,
encephalitis
,
fibrosarcoma
,
pancoast syndrome
,
myc genes
,
gene rearrangement
,
hiv seropositivity
,
behavior therapy
,
infections
,
supratentorial neoplasms
,
basal cell carcinoma
,
basal cell nevus syndrome
,
reactive arthritis
,
sertoli-leydig cell tumor
,
leydig cell tumor
,
granulosa cell tumor
,
lymphatic diseases
,
experimental neoplasms
,
optic nerve glioma
,
neurotoxicity syndromes
,
neurofibromatosis 1
,
neurofibromatoses
,
neurofibroma
,
hepatitis b
,
wounds and injuries
,
spinal cord injuries
,
paralysis
,
covid-19
,
adoptive immunotherapy
,
treatment refusal
,
oropharyngeal neoplasms
,
vascular diseases
,
peripheral arterial disease
,
atherosclerosis
,
intermittent claudication
,
peripheral vascular diseases
,
thoracic diseases
,
healthy volunteers/patients
,
ganglion cysts
,
hypersensitivity
,
disease progression
,
li-fraumeni syndrome
,
p53 genes
,
respiratory tract diseases
,
lung diseases
,
respiratory tract neoplasms
,
bronchogenic carcinoma
,
thoracic neoplasms
,
neoplasms by site
,
bronchial neoplasms
,
olfactory esthesioneuroblastoma
,
diabetes insipidus
,
chemoradiotherapy
,
myeloid leukemia
,
carcinoma
,
neuroblastoma
,
recurrence
,
multiple myeloma
,
sarcoma
,
plasma cell neoplasms
,
myelodysplastic syndromes
,
central nervous system neoplasms
,
preleukemia
,
ovarian neoplasms
,
nervous system neoplasms
,
follicular lymphoma
,
neuroendocrine carcinoma
,
brain neoplasms
,
breast neoplasms
,
small cell carcinoma
,
ewing sarcoma
,
neuroectodermal tumors
,
plasmablastic lymphoma
,
large-cell lymphoma immunoblastic
,
myeloproliferative disorders
,
osteosarcoma
,
testicular neoplasms
,
neoplasm metastasis
,
ependymoma
,
ovarian epithelial carcinoma
,
myelodysplastic-myeloproliferative diseases
,
bcr-abl positive chronic myelogenous leukemia
,
myelomonocytic leukemia acute
,
rhabdomyosarcoma
,
glioblastoma
,
prostatic neoplasms
,
kidney neoplasms
,
hematopoietic stem cell transplantation
,
t-cell leukemia
,
glioma
,
megakaryoblastic leukemia acute
,
monocytic leukemia acute
,
erythroblastic leukemia acute
,
drug-related side effects and adverse reactions
,
precursor t-cell lymphoblastic leukemia-lymphoma
,
hiv infections
,
teratoma
,
wilms tumor
,
primitive neuroectodermal tumors peripheral
,
acute disease
,
philadelphia chromosome
,
adenocarcinoma
,
liver neoplasms
,
adrenocortical carcinoma
,
rhabdoid tumor
,
ganglioneuroblastoma
,
seminoma
,
urinary bladder neoplasms
,
myelomonocytic leukemia chronic
,
phenylketonurias
,
sclerosis
,
thymoma
,
basophilic leukemia acute
,
hypereosinophilic syndrome
,
eosinophilic leukemia acute
,
squamous cell neoplasms
,
myelomonocytic leukemia juvenile
,
germinoma
,
multiple sclerosis
,
drug therapy
,
b-cell leukemia
,
squamous cell carcinoma
,
renal cell carcinoma
,
adenocarcinoma of lung
,
bronchiolo-alveolar adenocarcinoma
,
choriocarcinoma
,
endodermal sinus tumor
,
soft tissue neoplasms
,
stomach neoplasms
,
anemia
,
hepatoblastoma
,
classical conditioning
,
retinal neoplasms
,
promyelocytic leukemia acute
,
thymus neoplasms
,
bone marrow transplantation
,
biphenotypic leukemia acute
,
embryonal carcinoma
,
choroid plexus neoplasms
,
hepatocellular carcinoma
,
bone neoplasms
,
aplastic anemia
,
alveolar rhabdomyosarcoma
,
embryonal rhabdomyosarcoma
,
relapsing-remitting multiple sclerosis
,
squamous cell carcinoma of head and neck
,
kaposi sarcoma
,
unknown primary neoplasms
,
refractory anemia with excess of blasts
,
refractory anemia
,
mucositis
,
cardiotoxicity
,
epstein-barr virus infections
,
progression-free survival
,
myeloid sarcoma
,
second primary neoplasms
,
benign fibrous histiocytoma
,
histiocytoma
,
malignant fibrous histiocytoma
,
stomatitis
,
gestational trophoblastic disease
,
sex cord-gonadal stromal tumors
,
disease
,
down syndrome
,
adrenal cortex neoplasms
,
hyperthermia
,
nasopharyngeal neoplasms
,
human herpesvirus 4
,
hematopoietic stem cell mobilization
,
eyelid neoplasms
,
bone marrow diseases
,
chronic progressive multiple sclerosis
,
pathologic complete response
,
trophoblastic neoplasms
,
serous cystadenocarcinoma
,
hereditary breast and ovarian cancer syndrome
,
nasopharyngeal carcinoma
,
non-gestational choriocarcinoma
,
therapeutics
,
positron-emission tomography
,
adolescent development
,
lymphoma
,
lung neoplasms
,
leukemia
,
small cell lung carcinoma
,
non-hodgkin lymphoma
,
precursor cell lymphoblastic leukemia-lymphoma
,
b-cell lymphoma
,
large b-cell lymphoma diffuse
,
myeloid leukemia acute
,
neoplasms
,
hodgkin disease
,
lymphoid leukemia
,
non-small-cell lung carcinoma
,
t-cell lymphoma
,
t-cell lymphoma peripheral
,
germ cell and embryonal neoplasms
,
syndrome
,
mantle-cell lymphoma
,
burkitt lymphoma
,
retinoblastoma
,
hemophagocytic lymphohistiocytosis
,
large-cell lymphoma anaplastic
,
extranodal nk-t-cell lymphoma
,
primitive neuroectodermal tumors
,
medulloblastoma
,
immunoblastic lymphadenopathy
,
aggression
,
waldenstrom macroglobulinemia
,
enteropathy-associated t-cell lymphoma
,
neutropenia
,
nausea
,
vomiting
,
panniculitis
,
mediastinal neoplasms
,
cytokine release syndrome
,
chediak-higashi syndrome
,
paroxysmal hemoglobinuria
,
hemoglobinuria
,
multiple primary neoplasms
,
ataxia
,
ataxia telangiectasia
,
telangiectasis
,
cerebellar ataxia
,
peripheral blood stem cell transplantation
,
hip osteoarthritis
,
knee osteoarthritis
,
pressure ulcer
,
electric stimulation therapy
,
wiskott-aldrich syndrome
,
severe combined immunodeficiency
,
chronic granulomatous disease
,
immunologic deficiency syndromes
,
agammaglobulinemia
,
type 1 hyper-igm immunodeficiency syndrome
,
common variable immunodeficiency
,
hyper-igm immunodeficiency syndrome
,
leukocyte-adhesion deficiency syndrome
,
chronic disease
,
animal mammary neoplasms
,
induction chemotherapy
,
machine learning
,
treatment failure
,
environmental biomarkers
Catecholamines
healthy volunteers/patients
,
endocrine system diseases
,
exercise
,
psychotic disorders
,
pheochromocytoma
,
myocardial infarction
,
hyperkinesis
,
schizophrenia
,
neuroendocrine tumors
,
paraganglioma
,
infarction
,
inferior wall myocardial infarction
,
narcolepsy
,
neuroendocrine carcinoma
,
sleep initiation and maintenance disorders
,
craniocerebral trauma
,
nervous system trauma
,
drug-related side effects and adverse reactions
,
temporomandibular joint disorders
,
temporomandibular joint dysfunction syndrome
,
traumatic stress disorders
,
traumatic stress disorders acute
,
autonomic nervous system diseases
,
hypotension
,
nervous system diseases
,
primary dysautonomias
,
obesity
,
syndrome
,
orthostatic intolerance
,
postural orthostatic tachycardia syndrome
,
anorexia
,
orthostatic hypotension
,
cardiac surgical procedures
,
respiratory distress syndrome
,
bronchiolitis
,
weight loss
,
fluid therapy
,
infections
,
low cardiac output
,
cachexia
,
acute lung injury
,
newborn respiratory distress syndrome
,
carotid stenosis
,
neonatal sepsis
,
shock
,
septic shock
,
hypertension
,
wounds and injuries
,
sepsis
,
diabetes mellitus
,
hypoglycemia
,
traumatic brain injuries
,
brain injuries
,
heart failure
,
type 1 diabetes mellitus
,
tachycardia
,
critical illness
,
cardiogenic shock
,
type 2 diabetes mellitus
,
cardiac arrhythmias
,
covid-19
,
coronavirus infections
,
respiratory tract diseases
,
respiration disorders
,
endotoxemia
,
parkinson disease
,
psychological stress
,
acute kidney injury
,
pure autonomic failure
,
inflammation
,
depressive disorder
,
respiratory insufficiency
,
cardiovascular diseases
,
takotsubo cardiomyopathy
,
essential hypertension
,
depression
,
attention deficit disorder with hyperactivity
,
cardiomyopathies
,
hemorrhage
,
ischemic stroke
,
subarachnoid hemorrhage
,
stroke
,
adrenal gland neoplasms
,
adrenocortical carcinoma
,
anorexia nervosa
,
hyperaldosteronism
,
chronic kidney failure
,
bradycardia
,
shy-drager syndrome
,
multiple system atrophy
,
atrophy
,
autoimmune diseases
,
major depressive disorder
,
bulimia
,
feeding and eating disorders
,
bulimia nervosa
,
reward
,
kidney diseases
,
heart diseases
,
metabolic syndrome
,
neuralgia
,
restless legs syndrome
,
psychomotor agitation
,
physiological stress
,
burns
,
intraoperative complications
,
high cardiac output
,
respiratory aspiration of gastric contents
,
multiple organ failure
,
hyperemia
,
adrenal insufficiency
,
prostatic neoplasms
,
chronic obstructive pulmonary disease
,
treatment outcome
,
cytokine release syndrome
,
toxemia
,
heart arrest
,
mammaplasty
,
free tissue flaps
,
microsurgery
,
glaucoma
,
raynaud disease
,
hand-arm vibration syndrome
,
postoperative pain
,
postoperative complications
,
ultrasonic therapy
,
vitiligo
,
hematoma
,
pulmonary embolism
,
embolism
,
obstructive sleep apnea
,
sleep apnea syndromes
,
apnea
,
menopause
,
sudden death cardiac
,
death
,
food intolerance
,
enteral nutrition
,
vasovagal syncope
,
syncope
,
post-traumatic stress disorders
,
abdominal obesity
,
adrenocortical adenoma
,
delirium
,
melanoma
,
acute coronary syndrome
,
pancreatitis
,
phenylketonurias
,
aphthous stomatitis
,
stomatitis
,
thyroid diseases
,
neuroblastoma
,
precancerous conditions
,
hyperplasia
,
congenital adrenal hyperplasia
,
adrenogenital syndrome
,
adrenocortical hyperfunction
,
open-angle glaucoma
,
hypersensitivity
,
laparoscopic cholecystectomy
,
lung injury
,
heart disease risk factors
,
sleep
,
circadian rhythm
,
knee osteoarthritis
,
osteoarthritis
,
fasting
,
cold temperature
,
myofascial pain syndromes
,
fibromyalgia
,
renal insufficiency
,
hypoxia
,
altitude sickness
,
resistance training
,
blood flow restriction therapy
,
pituitary acth hypersecretion
,
cushing syndrome
,
adrenal rest tumor
,
adrenal gland diseases
,
neoplasm metastasis
,
spinal cord injuries
,
pulmonary heart disease
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