Esperion Therapeutics - PharmaKB

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Company ReportsEsperion Therapeutics

Esperion Therapeutics(ESPR)

Esperion Therapeutics, Inc. is a public American pharmaceutical company focused on the development of bempedoic acid, an orally available small molecule designed to lower elevated levels of LDL-C. The company is headquartered in Ann Arbor, Michigan.

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Trade Name	Drug Name	Approved	Patent Expires	Indication
Nexletol	Bempedoic acid	2020-02-21	2025-2040	Hypercholesterolemia , Dyslipidemias , Atherosclerosis , Hyperlipoproteinemia type ii , Familial combined hyperlipidemia
Nexlizet	Bempedoic acid, Ezetimibe	2020-02-26	2025-2040	Hypercholesterolemia , Dyslipidemias , Atherosclerosis , Hyperlipoproteinemia type ii , Familial combined hyperlipidemia

Clinical Trials

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Phase 3

Phase 4

Indication

pharmacokinetics

,

drug interactions

,

immunosuppression therapy

,

,

pharmacological phenomena

,

,

therapeutic equivalency

,

endometrial neoplasms

,

acute kidney injury

,

alopecia areata

,

,

pancreatic ductal carcinoma

,

pancreatic neoplasms

,

,

healthy volunteers/patients

,

chronic hepatitis

,

chronic hepatitis d

,

,

prostatic neoplasms

,

diabetic neuropathies

,

polyneuropathies

,

oxidative stress

,

,

hyperlipoproteinemia type ii

,

homozygous familial hypercholesterolemia

,

inborn errors lipid metabolism

,

inborn errors metabolism

,

essential hypertension

,

vascular diseases

,

aortic valve stenosis

,

pathologic constriction

,

left ventricular hypertrophy

,

,

diabetic nephropathies

,

,

kidney transplantation

,

lung transplantation

,

communicable diseases

,

insulin resistance

,

,

hypercholesterolemia

,

,

coronary artery disease

,

hyperlipidemias

,

coronary disease

,

myocardial ischemia

,

atherosclerosis

,

,

cardiovascular diseases

,

diabetes mellitus

,

hyperlipoproteinemias

,

type 2 diabetes mellitus

,

acute coronary syndrome

,

,

myocardial infarction

,

metabolic syndrome

,

,

,

atherosclerotic plaque

,

,

,

,

hypertriglyceridemia

,

kidney diseases

,

,

peripheral arterial disease

,

chronic renal insufficiency

,

st elevation myocardial infarction

,

metabolic diseases

,

,

non-alcoholic fatty liver disease

,

,

familial combined hyperlipidemia

,

ischemic stroke

,

,

lipid metabolism disorders

,

drug-related side effects and adverse reactions

,

peripheral vascular diseases

,

chronic hepatitis c

,

,

type 1 diabetes mellitus

,

non-st elevated myocardial infarction

,

cognitive dysfunction

,

,

,

alcoholic fatty liver

,

carotid artery diseases

,

preconception care

,

renin-angiotensin system

,

vitamin d deficiency

,

endocrine system diseases

,

nutritional and metabolic diseases

,

left ventricular dysfunction

,

vascular stiffness

,

transplantation

,

renal insufficiency

,

atrial fibrillation

,

magnetic resonance imaging

,

neuropsychology

,

,

arteriosclerosis

,

chronic disease

,

vascular calcification

,

,

inferior wall myocardial infarction

,

,

cerebrovascular disorders

,

prediabetic state

,

hyperlipoproteinemia type v

,

,

genetic testing

,

hyperlipoproteinemia type iii

,

,

medication adherence

,

treatment adherence and compliance

,

patient compliance

,

motivational interviewing

,

,

intestinal diseases

,

heart disease risk factors

,

glucose intolerance

,

,

acalculous cholecystitis

,

alzheimer disease

,

,

,

coronavirus infections

,

,

,

disease progression

,

thrombocytopenic purpura idiopathic

,

thrombocytopenia

,

cerebral infarction

,

secondary prevention

,

cerebral small vessel diseases

,

percutaneous coronary intervention

invasive candidiasis

,

,

,

invasive pulmonary aspergillosis

healthy volunteers/patients

,

rheumatoid arthritis

,

,

acute kidney injury

,

drug interactions

,

therapeutic equivalency

,

hiv seronegativity

,

nephrotic syndrome

,

,

,

biotransformation

,

pharmacokinetics

,

peripheral arterial disease

,

ventilator-associated pneumonia

,

,

wounds and injuries

,

hematopoietic stem cell transplantation

,

fontan procedure

,

univentricular heart

,

,

,

,

,

myeloid leukemia acute

,

megakaryoblastic leukemia acute

,

monocytic leukemia acute

,

myelomonocytic leukemia acute

,

myeloid leukemia

,

erythroblastic leukemia acute

,

,

,

metabolic diseases

,

pulmonary fibrosis

,

hermanski-pudlak syndrome

,

oculocutaneous albinism

,

platelet storage pool deficiency

,

,

colorectal neoplasms

,

,

uveal neoplasms

,

systemic lupus erythematosus

,

hematologic neoplasms

,

,

,

cardiomyopathies

,

pulmonary tuberculosis

,

liver cirrhosis

,

mucocutaneous lymph node syndrome

,

,

,

metabolic syndrome

,

atherosclerosis

,

hyperlipoproteinemia type ii

,

breast neoplasms

,

hepatocellular carcinoma

,

liver neoplasms

,

,

,

chronic kidney failure

,

vascular diseases

,

,

left ventricular hypertrophy

,

,

multiple sclerosis

,

relapsing-remitting multiple sclerosis

,

,

homozygous familial hypercholesterolemia

,

familial combined hyperlipidemia

,

,

small cell lung carcinoma

,

hyperlipoproteinemia type iii

,

arterial occlusive diseases

,

,

retinal diseases

,

pregnancy-induced hypertension

,

obstetric labor complications

,

disease progression

,

vascular dementia

,

cognitive dysfunction

,

hypercholesterolemia

,

,

,

cardiovascular diseases

,

hyperlipidemias

,

coronary artery disease

,

diabetes mellitus

,

hyperlipoproteinemias

,

coronary disease

,

myocardial ischemia

,

,

,

,

,

acute coronary syndrome

,

ischemic stroke

,

type 2 diabetes mellitus

,

,

myocardial infarction

,

,

hypertriglyceridemia

,

kidney diseases

,

,

angina pectoris

,

,

,

drug-related side effects and adverse reactions

,

polycystic kidney diseases

,

autosomal dominant polycystic kidney

,

transient ischemic attack

,

,

,

chronic renal insufficiency

,

psychotic disorders

,

,

,

,

cerebral infarction

,

drug-eluting stents

,

,

postmenopausal osteoporosis

,

acute-phase reaction

,

,

prediabetic state

,

,

alzheimer disease

,

,

glucose metabolism disorders

,

lipid metabolism

,

stomach neoplasms

,

esophageal neoplasms

,

inferior wall myocardial infarction

,

arteriosclerosis

,

st elevation myocardial infarction

,

unstable angina

,

malignant hyperthermia

,

prostatic neoplasms

,

postpartum depression

,

myelodysplastic syndromes

,

myeloproliferative disorders

,

myelomonocytic leukemia chronic

,

,

myelodysplastic-myeloproliferative diseases

,

myelomonocytic leukemia juvenile

,

,

refractory anemia with excess of blasts

,

refractory anemia

,

carotid artery diseases

,

,

,

acquired immunodeficiency syndrome

,

,

,

muscular diseases

,

,

myeloid leukemia acute

,

myeloid leukemia

,

,

non-alcoholic fatty liver disease

,

,

,

non-small-cell lung carcinoma

,

small cell lung carcinoma

,

prostatic neoplasms

,

castration-resistant prostatic neoplasms

,

,

hepatocellular carcinoma

,

liver neoplasms

,

,

,

,

pancreatic neoplasms

,

central nervous system neoplasms

,

colorectal neoplasms

,

head and neck neoplasms

,

thyroid neoplasms

,

breast neoplasms

,

ovarian neoplasms

,

ovarian epithelial carcinoma

,

,

depressive disorder

,

hereditary breast and ovarian cancer syndrome

,

triple negative breast neoplasms

,

bipolar disorder

,

hypercholesterolemia

,

,

biliary tract neoplasms

,

fallopian tube neoplasms

,

systemic lupus erythematosus

,

chronic obstructive pulmonary disease

,

,

type 2 diabetes mellitus

,

,

diabetes mellitus

,

,

myocardial infarction

,

,

,

pulmonary eosinophilia

,

urologic neoplasms

,

major depressive disorder

,

,

gastrointestinal hemorrhage

,

b-cell chronic lymphocytic leukemia

,

lymphoid leukemia

,

second primary neoplasms

,

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

multiple pulmonary nodules

,

solitary pulmonary nodule

,

percutaneous coronary intervention

,

inferior wall myocardial infarction

,

mental disorders

,

,

urinary bladder neoplasms

,

invasive hydatidiform mole

,

non-muscle invasive bladder neoplasms

,

metabolic diseases

,

metabolic bone diseases

,

,

osteoporotic fractures

,

obstructive lung diseases

,

systolic heart failure

,

cardiovascular diseases

,

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